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Death receptor signalling in tumour immune editing

Objective

During tumour development there is a bi-directional communication between cancer cells and immune cells; the process termed tumour immune editing. The impact is reciprocal, shaping both the visibility and susceptibility of the tumour to immune eradication as well as the ability of the immune effector cells to recognise and launch an immune response against tumour cells. Death ligand-death receptor signalling is a key mechanism to kill tumour cells during the early stages of tumour development (tumour immune surveillance). However, the role of this signalling pathway in evolved tumours is poorly understood. Recent pioneering results from DISCOVER consortium members highlighted non-canonical signal tranduction pathways mediated by death receptors, which regulates both tumour cell behaviour (motility, invasion) and effector immune cell function in the tumour microenvironment.
The aim of the DISCOVER proposal is to bring a collaborative research network together to determine the role of death ligand-death receptor signalling in tumour - immune cell interactions. The DISCOVER programme will determine how non-canonical signal transduction pathways driven by death receptors control effector immnue cell functions and tumour cell behaviour. The outputs of the research will be used to develop informed therapeutic strategies to interfere with non-canonical death receptor signalling in order to re-activate anti-tumour immune attack and sensitise tumour cells to this attack.
The DISCOVER proposal will integrate the research activity of seven beneficiary organisations from 5 European countries, including 3 companies and create a framework for knowledge and reagent exchange for early stage and experienced researchers. The consortium will bring together scientists from immunology and cancer cell biology and combines these with expertise in systems biology, drug discovery and pre-clinical drug development thus forging a consortium where scientific discoveries drive innovation.

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Net EU contribution
€ 40 500,00
Address
University Road
H91 Galway
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (8)

CELL STRESS DISCOVERIES LIMITED
Ireland
Net EU contribution
€ 274 500,00
Address
Unit 204, Nuig Business Innovation Centre, Newcastle Road
Galway

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Northern and Western West
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
DOKUZ EYLUL UNIVERSITESI
Turkey
Net EU contribution
€ 144 000,00
Address
Cumhuriyet Bulvari 144
35210 Alsancak Izmir

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Region
Ege İzmir İzmir
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
APOFAS BIOTECH

Participation ended

France
Net EU contribution
€ 0,00
Address
2 Rue Du Professeur Leon Bernard Campus De Villeje Bat 8 Biosit
35043 Rennes

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bretagne Bretagne Ille-et-Vilaine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAET BERN
Switzerland
Net EU contribution
€ 27 000,00
Address
Hochschulstrasse 6
3012 Bern

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 171 000,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA
Greece
Net EU contribution
€ 193 500,00
Address
Al. Pantou 25
17671 Kallithea

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Νότιος Τομέας Αθηνών Aττική Αττική
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
IZMIR BIYOTIP VE GENOM MERKEZI
Turkey
Net EU contribution
€ 27 000,00
Address
Mithatpasa Cad. No:58/5 Balcova
35340 Izmir

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Region
Ege İzmir İzmir
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SEQOME LIMITED
Ireland
Net EU contribution
€ 27 000,00
Address
8 Cremore Drive Grange Manor
Waterford

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00