CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.
Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .
Livrables
The organization of a school on the synthesis and characterization of hybrid materials for medical applications will allow to share the know-how relative to the project among consortium partners, as well as serving as a meeting to strengthen teamwork and build new collaborations.
Protocols for the characterization of the behavior of hybrid supramolecular nanostructures (s’ouvre dans une nouvelle fenêtre)Protocols should push for high quality data, ensure that experimental results can be confidently shared among research partners and allow meaningful comparison with data reported in published material. The characterization of the behavior of hybrid supramolecular nanostructures in solution will rely on an array of techniques including dynamic light scattering, small-angle X-ray scattering, photophysics, confocal (optical) microscopy. The characterization of the behavior of hybrid supramolecular nanostructures on surfaces will rely on electron microscopies (ESEM, SEM, TEM), liquid drop contact angle, profilometry.
DNA/PNA-BioMSNPs (s’ouvre dans une nouvelle fenêtre)Production of DNA-BioMSNPs based on Watson and Crick interaction of complementary DNA probes rationally inserted into the programmable SiO2 framework of MSNPs. (M. 24). At least 10 mg of DNA-BioMSNPs based on Watson and Crick interaction of complementary DNA probes rationally inserted into the programmable SiO2 framework of MSNPs.
Production of DNA nanocubes entrapped into Quatsomes (s’ouvre dans une nouvelle fenêtre)Production of 5 mg of DNA nanocubes entrapped into QS, for oligonucleotide-delivery applications.
Porous silicon nanoparticles (s’ouvre dans une nouvelle fenêtre)Production of porous silicon nanoparticles for the delivery of specific PNAs and DNA therapeutics on a 10mg-scale, by etching of silicon wafers with hydrofluoric acid in ethanol. The pore size of the particles must support the loading of oligonucleotides.
Feedback on anti-miR activity of oligonucleotide-based therapy mediated by hybrid nanocarriers (s’ouvre dans une nouvelle fenêtre)Quantitative evaluation of the anti-miR activity of breakable miR-responsive BioMSNPs in vitro.
Multifunctional nanomaterials as improved nanocarriers for oligonucleotide delivery (s’ouvre dans une nouvelle fenêtre)Comparison of the developed hybrid multifunctional nanomaterials as improved nanocarriers for oligonucleotide-delivery in cancer cells, vs literature systems.
Protocol for the study of stimuli-responsive DNA nanomachines (s’ouvre dans une nouvelle fenêtre)The protocol should push for high quality data, ensure that experimental results can be confidently shared among research partners and allow meaningful comparison with data reported in published material. The characterization of stimuli-responsive DNA nanomachines will rely on an array of techniques including fluorescence spectroscopies, microscopies and gel electrophoresis.
PNA-based nanocubes for drug-delivery (s’ouvre dans une nouvelle fenêtre)Protocol for synthesis and characterization of stimuli-responsive PNA nanocubes on at least a 1mg-scale. PNA nanocubes must be able to release a model cargo, such as doxorubicin or camptotechin, upon exposure to a chemical stimulus.
Protocol for the synthesis of DNA, its modification and conjugation with FRET pair and small molecules (s’ouvre dans une nouvelle fenêtre)The protocol should provide high-purity, completely characterized materials and molecules, to ensure that products can be confidently shared among research partners and contribute to the positive outcome of the research effort.
Creation of a website of the project to announce and disseminate published results to the general public (journal papers, youtube videos, etc.)
Publications
Auteurs:
Stefano Volpi; Umberto Cancelli; Martina Neri; Roberto Corradini
Publié dans:
Pharmaceuticals, Numéro Vol. 14, 2021, Page(s) 1-31, ISSN 1424-8247
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14010014
Auteurs:
Martina Neri; Jinyoung Kang; Jonathan M. Zuidema; Jessica Gasparello; Alessia Finotti; Roberto Gambari; Michael J. Sailor; Alessandro Bertucci; Roberto Corradini
Publié dans:
ACS Biomaterials Science and Engineering, Numéro 8, 2022, Page(s) ACS Biomaterials Science and Engineering, ISSN 2373-9878
Éditeur:
American Chemical Society
DOI:
10.1021/acsbiomaterials.1c00431
Auteurs:
Marianna Rossetti, Alessandro Bertucci, Tania Patiño, Lorena Baranda, Alessandro Porchetta
Publié dans:
Chemistry- A European Journal, Numéro 26, 2020, ISSN 0947-6539
Éditeur:
John Wiley & Sons Ltd.
DOI:
10.5281/zenodo.7650839
Auteurs:
María Sancho-Albero, Giorgio Facchetti, Nicolò Panini, Marina Meroni, Ezia Bello, Isabella Rimoldi, Massimo Zucchetti, Roberta Frapolli, Luisa De Cola
Publié dans:
Advanced Healthcare Materials, 2023, ISSN 2192-2640
Éditeur:
John Wiley and Sons Ltd
DOI:
10.1002/adhm.202202932
Auteurs:
Marianna Rossetti; Lorenzo Stella; Judit Morla-Folch; Sara Bobone; Ariadna Boloix; Lorena Baranda; Danila Moscone; Mónica Roldán; Jaume Veciana; Miguel F. Segura; Mariana Köber; Nora Ventosa; Alessandro Porchetta
Publié dans:
Advanced Functional Materials, Numéro 3, 2021, Page(s) Volume 31, Numéro 46, Article number 2103511, ISSN 1616-301X
Éditeur:
John Wiley & Sons Ltd.
DOI:
10.1002/adfm.202103511
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