CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
The organization of a school on the synthesis and characterization of hybrid materials for medical applications will allow to share the know-how relative to the project among consortium partners, as well as serving as a meeting to strengthen teamwork and build new collaborations.
Protocols for the characterization of the behavior of hybrid supramolecular nanostructures (si apre in una nuova finestra)Protocols should push for high quality data, ensure that experimental results can be confidently shared among research partners and allow meaningful comparison with data reported in published material. The characterization of the behavior of hybrid supramolecular nanostructures in solution will rely on an array of techniques including dynamic light scattering, small-angle X-ray scattering, photophysics, confocal (optical) microscopy. The characterization of the behavior of hybrid supramolecular nanostructures on surfaces will rely on electron microscopies (ESEM, SEM, TEM), liquid drop contact angle, profilometry.
DNA/PNA-BioMSNPs (si apre in una nuova finestra)Production of DNA-BioMSNPs based on Watson and Crick interaction of complementary DNA probes rationally inserted into the programmable SiO2 framework of MSNPs. (M. 24). At least 10 mg of DNA-BioMSNPs based on Watson and Crick interaction of complementary DNA probes rationally inserted into the programmable SiO2 framework of MSNPs.
Production of DNA nanocubes entrapped into Quatsomes (si apre in una nuova finestra)Production of 5 mg of DNA nanocubes entrapped into QS, for oligonucleotide-delivery applications.
Porous silicon nanoparticles (si apre in una nuova finestra)Production of porous silicon nanoparticles for the delivery of specific PNAs and DNA therapeutics on a 10mg-scale, by etching of silicon wafers with hydrofluoric acid in ethanol. The pore size of the particles must support the loading of oligonucleotides.
Feedback on anti-miR activity of oligonucleotide-based therapy mediated by hybrid nanocarriers (si apre in una nuova finestra)Quantitative evaluation of the anti-miR activity of breakable miR-responsive BioMSNPs in vitro.
Multifunctional nanomaterials as improved nanocarriers for oligonucleotide delivery (si apre in una nuova finestra)Comparison of the developed hybrid multifunctional nanomaterials as improved nanocarriers for oligonucleotide-delivery in cancer cells, vs literature systems.
Protocol for the study of stimuli-responsive DNA nanomachines (si apre in una nuova finestra)The protocol should push for high quality data, ensure that experimental results can be confidently shared among research partners and allow meaningful comparison with data reported in published material. The characterization of stimuli-responsive DNA nanomachines will rely on an array of techniques including fluorescence spectroscopies, microscopies and gel electrophoresis.
PNA-based nanocubes for drug-delivery (si apre in una nuova finestra)Protocol for synthesis and characterization of stimuli-responsive PNA nanocubes on at least a 1mg-scale. PNA nanocubes must be able to release a model cargo, such as doxorubicin or camptotechin, upon exposure to a chemical stimulus.
Protocol for the synthesis of DNA, its modification and conjugation with FRET pair and small molecules (si apre in una nuova finestra)The protocol should provide high-purity, completely characterized materials and molecules, to ensure that products can be confidently shared among research partners and contribute to the positive outcome of the research effort.
Creation of a website of the project to announce and disseminate published results to the general public (journal papers, youtube videos, etc.)
Pubblicazioni
Autori:
Stefano Volpi; Umberto Cancelli; Martina Neri; Roberto Corradini
Pubblicato in:
Pharmaceuticals, Numero Vol. 14, 2021, Pagina/e 1-31, ISSN 1424-8247
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14010014
Autori:
Martina Neri; Jinyoung Kang; Jonathan M. Zuidema; Jessica Gasparello; Alessia Finotti; Roberto Gambari; Michael J. Sailor; Alessandro Bertucci; Roberto Corradini
Pubblicato in:
ACS Biomaterials Science and Engineering, Numero 8, 2022, Pagina/e ACS Biomaterials Science and Engineering, ISSN 2373-9878
Editore:
American Chemical Society
DOI:
10.1021/acsbiomaterials.1c00431
Autori:
Marianna Rossetti, Alessandro Bertucci, Tania Patiño, Lorena Baranda, Alessandro Porchetta
Pubblicato in:
Chemistry- A European Journal, Numero 26, 2020, ISSN 0947-6539
Editore:
John Wiley & Sons Ltd.
DOI:
10.5281/zenodo.7650839
Autori:
María Sancho-Albero, Giorgio Facchetti, Nicolò Panini, Marina Meroni, Ezia Bello, Isabella Rimoldi, Massimo Zucchetti, Roberta Frapolli, Luisa De Cola
Pubblicato in:
Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore:
John Wiley and Sons Ltd
DOI:
10.1002/adhm.202202932
Autori:
Marianna Rossetti; Lorenzo Stella; Judit Morla-Folch; Sara Bobone; Ariadna Boloix; Lorena Baranda; Danila Moscone; Mónica Roldán; Jaume Veciana; Miguel F. Segura; Mariana Köber; Nora Ventosa; Alessandro Porchetta
Pubblicato in:
Advanced Functional Materials, Numero 3, 2021, Pagina/e Volume 31, Numero 46, Article number 2103511, ISSN 1616-301X
Editore:
John Wiley & Sons Ltd.
DOI:
10.1002/adfm.202103511
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