Chiroptical, optical and magnetic probes for protein sensing based on cage metal complexes

Project Information

CLATHROPROBES

Grant agreement ID: 778245

DOI 10.3030/778245

Project closed

EC signature date 17 October 2017

Start date 1 January 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 855 000,00

EU contribution € 796 500,00

Coordinated by

UNIWERSYTET WROCLAWSKI
Poland

Deliverables

Websites, patent fillings, videos etc. (4)

Three research paper on the topic of WP3
Internet website of the project

Internet website highlighting the research activity of the project and providing information about its progress

Three research papers on the topic of WP2
Two research papers on the topic of WP1

Publications

Peer reviewed articles (25)

Spectroelectrochemical Properties and Catalytic Activity in Cyclohexane Oxidation of the Hybrid Zr/Hf-Phthalocyaninate-Capped Nickel(II) and Iron(II) tris-Pyridineoximates and Their Precursors.

Author(s): Yan Z. Voloshin; Semyon V. Dudkin; Svetlana A. Belova; Daniel Gherca; Dumitru Samohvalov; Corina-Mihaela Manta; Maria-Andreea Lungan; Samuel M. Meier-Menches; Peter Rapta; Denisa Darvasiová; Michal Malček; Armando J. L. Pombeiro; Luísa M. D. R. S. Martins; Vladimir B. Arion
Published in: Molecules, Issue 26 (17), 2021, Page(s) 336, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020336

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Author(s): Insa Klemt; Oleg Varzatskii; Roman Selin; Serhii Vakarov; Vladyslava Kovalska; Galyna Bila; Rostyslav Bilyy; Yan Voloshin; Itziar Cossío Cuartero; Andrés Hidalgo; Benjamin Frey; Ina Becker; Bernhard Friedrich; Rainer Tietze; Ralf P. Friedrich; Christoph Alexiou; Elena-Laura Ursu; Alexandru Rotaru; Iris Solymosi; M. Eugenia Pérez-Ojeda; Andriy Mokhir
Published in: J. Am. Chem. Soc., Issue 145 (40), 2023, Page(s) 22252-22264, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c08827

Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

Author(s): Hyeon Joo Yoo, Yibin Liu, Lei Wang, Maria-Luisa Schubert, Jean-Marc Hoffmann, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Andriy Mokhir, Michael Schmitt, Leopold Sellner
Published in: International Journal of Molecular Sciences, Issue 20/10, 2019, Page(s) 2469, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20102469

Inhibition of DNA synthesis in the transcription system of Taq DNA polymerase by various iron and cobalt(II) tris-dioximate clathrochelates: In vitro study and X-ray structure of leader inhibitors, the carboxyl-terminated macrobicyclic complexes☆

Author(s): Oleg A. Varzatskii, Anna V. Vologzhanina, Valentin V. Novikov, Serhii V. Vakarov, Ruslan V. Oblap, Yan Z. Voloshin
Published in: Inorganica Chimica Acta, Issue 482, 2018, Page(s) 90-98, ISSN 0020-1693
Publisher: Elsevier BV
DOI: 10.1016/j.ica.2018.06.004

A cancer specific oxaliplatin-releasing Pt( iv )-prodrug

Author(s): Viktor Reshetnikov, Anton Arkhypov, Purushottam Reddy Julakanti, Andriy Mokhir
Published in: Dalton Transactions, Issue 47/19, 2018, Page(s) 6679-6682, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8dt01458b

Crystal structure and Hirshfeld surface analysis of poly[[bis-[μ4-N,N'-(1,3,5-oxadiazinane-3,5-di-yl)bis(carbamoyl-methano-ato)]nickel(II)tetra-potassium] 4.8-hydrate].

Author(s): Maksym O. Plutenko; Matti Haukka; Alina O. Husak; Turganbay S. Iskenderov; Nurullo U. Mulloev
Published in: Acta Crystallographica Section E: Crystallographic Communications, Issue 2, 2021, Page(s) 298-304, ISSN 2056-9890
Publisher: International Union of Crystallography
DOI: 10.1107/s205698902100205x

Crystal structure and Hirshfeld surface analysis of poly[[tetraaqua(μ-1,3,4,7,8,10,12,13,16,17,19,22-dodecaazatetracyclo[8.8.4.1^3,17.1^8,12]tetracosane-5,6,14,15,20,21-hexaonato)iron(IV)dilithium] tetrahydrate]

Author(s): Maksym O. Plutenko; Sergiu Shova; Vadim A. Pavlenko; Irina A. Golenya; Igor O. Fritsky
Published in: Acta Crystallographica Section E: Crystallographic Commun., Issue E79, 2023, Page(s) 1059-1062, ISSN 2056-9890
Publisher: International Union of Crystallography
DOI: 10.1107/s2056989023008587

Synthesis and spectral characterization of the first fluorescein-tagged iron(II) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake

Author(s): Roman O. Selin; Insa Klemt; Viktor Chernii; Mykhaylo Yu. Losytskyy; Svitlana Chernii; Andrzej Mular; Elzbieta Gumienna-Kontecka; Vladyslava B. Kovalska; Yan Z. Voloshin; Anna V. Vologzhanina; Pavel V. Dorovatovskii; Andriy Mokhir
Published in: RSC ADVANCES, Issue 6, 2021, Page(s) 8163-8177, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ra10502c

Induced chirality of cage metal complexes switched by their supramolecular and covalent binding

Author(s): Vladyslava B. Kovalska, Serhii V. Vakarov, Marina V. Kuperman, Mykhaylo Y. Losytskyy, Elzbieta Gumienna-Kontecka, Yan Z. Voloshin, Oleg A. Varzatskii
Published in: Dalton Transactions, Issue 47/4, 2018, Page(s) 1036-1052, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7dt03731g

Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils

Author(s): Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir
Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 1827, ISSN 1664-3224
Publisher: FrontiersMediaSA
DOI: 10.3389/fimmu.2018.01827

Synthesis and characterization of an Fe( i ) cage complex with high stability towards strong H-acids

Author(s): Yan Z. Voloshin, Valentin V. Novikov, Yulia V. Nelyubina, Alexander S. Belov, Dmitrii M. Roitershtein, Anton Savitsky, Andriy Mokhir, Jörg Sutter, Matthias E. Miehlich, Karsten Meyer
Published in: Chemical Communications, Issue 54/28, 2018, Page(s) 3436-3439, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc09611a

Extension and functionalization of an encapsulating macrobicyclic ligand using palladium-catalyzed Suzuki–Miyaura and Sonogashira reactions of iron( ii ) dihalogenoclathrochelates with inherent halogen substituents

Author(s): Irina N. Denisenko, Oleg A. Varzatskii, Roman A. Selin, Alexander S. Belov, Ekaterina G. Lebed, Anna V. Vologzhanina, Yan V. Zubavichus, Yan Z. Voloshin
Published in: RSC Advances, Issue 8/24, 2018, Page(s) 13578-13587, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ra01819g

The molecular design of cage metal complexes for biological applications: pathways of the synthesis, and X-ray structures of a series of new N 2 -, S 2 - and O 2 -alicyclic iron( ii ) di- and tetrachloroclathrochelates

Author(s): Genrikh E. Zelinskii, Alexander S. Belov, Irina G. Belaya, Anna V. Vologzhanina, Valentin V. Novikov, Oleg A. Varzatskii, Yan Z. Voloshin
Published in: New Journal of Chemistry, Issue 42/1, 2018, Page(s) 56-66, ISSN 1144-0546
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nj03051g

Very Large Magnetic Anisotropy of Cage Cobalt(II) Complexes with a Rigid Cholesteryl Substituent from Paramagnetic NMR Spectroscopy

Author(s): Alexander A. Pavlov, Svetlana A. Savkina, Alexander S. Belov, Yan Z. Voloshin, Yulia V. Nelyubina, Valentin V. Novikov
Published in: ACS Omega, Issue 3/5, 2018, Page(s) 4941-4946, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.8b00772

Efficient visible light-driven water oxidation catalysed by an iron( iv ) clathrochelate complex

Author(s): Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Fikret Mamedov, Jacinto Sá, Gustav Berggren, Igor O. Fritsky
Published in: Chemical Communications, Issue 55/23, 2019, Page(s) 3335-3338, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc00229d

Induced CD of iron( ii ) clathrochelates: sensing of the structural and conformational alterations of serum albumins

Author(s): Vladyslava Kovalska, Marina Kuperman, Mykhaylo Losytskyy, Serhii Vakarov, Slawomir Potocki, Sergiy Yarmoluk, Yan Voloshin, Oleg Varzatskii, Elzbieta Gumienna-Kontecka
Published in: Metallomics, Issue 11/2, 2019, Page(s) 338-348, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8mt00278a

Photoinduced hole transfer from tris(bipyridine)ruthenium dye to a high-valent iron-based water oxidation catalyst

Author(s): Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Igor O. Fritsky, Gustav Berggren
Published in: Faraday Discussions, Issue 215, 2019, Page(s) 162-174, ISSN 1359-6640
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8fd00167g

Dicarboxyl-terminated iron( ii ) clathrochelates as ICD-reporters for globular proteins

Author(s): Vladyslava Kovalska, Serhii Vakarov, Mykhaylo Losytskyy, Marina Kuperman, Nina Chornenka, Yuliya Toporivska, Elzbieta Gumienna-Kontecka, Yan Voloshin, Oleg Varzatskii, Andriy Mokhir
Published in: RSC Advances, Issue 9/42, 2019, Page(s) 24218-24230, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ra04102h

Chemical design of the heterodifunctionalized iron(II) clathrochelates with terminal biorelevant carboxyl group and reactive triple C≡C bond: Synthesis, structure, redox properties and their stability in various media

Author(s): Roman A. Selin, Nina V. Chornenka, Viktor Ya. Chernii, Andriy Mokhir, Anna V. Vologzhanina, Alexander S. Belov, Alexander L. Pomadchik, Yan Z. Voloshin
Published in: Inorganica Chimica Acta, Issue 496, 2019, Page(s) 119047, ISSN 0020-1693
Publisher: Elsevier BV
DOI: 10.1016/j.ica.2019.119047

Pseudomacrobicyclic Phthalocyaninate-Capped Cobalt(III) tris-Pyridineoximates: Template Synthesis, X-Ray Structure and Spectral Characteristics

Author(s): Svetlana A. Belova (Savkina), Semyon V. Dudkin, Alexander S. Belov, Yulia V. Nelyubina, Valentin V. Novikov, Yan V. Zubavichus, Yan Z. Voloshin
Published in: Macroheterocycles, Issue 12/2, 2019, Page(s) 193-197, ISSN 1998-9539
Publisher: Ivanovo State University of Chemistry and Technology
DOI: 10.6060/mhc190550d

Sensing of Proteins by ICD Response of Iron(II) Clathrochelates Functionalized by Carboxyalkylsulfide Groups

Author(s): Mykhaylo Losytskyy, Nina Chornenka, Serhii Vakarov, Samuel M. Meier-Menches, Christopher Gerner, Slawomir Potocki, Vladimir B. Arion, Elzbieta Gumienna-Kontecka, Yan Voloshin, Vladyslava Kovalska
Published in: Biomolecules, Issue 10/12, 2020, Page(s) 1602, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10121602

SYNTHESIS OF MODYFIED FLUORESCEINE FOR CLICK REACTIONS

Author(s): Roman Selin, Viktor Chernii, Andriy Mokhir
Published in: Ukrainian Chemistry Journal, Issue 86/3, 2020, Page(s) 3-8, ISSN 0041-6045
Publisher: National'na Akademiya Nauk Ukrainy
DOI: 10.33609/0041-6045.86.3.2020.3-8

Esterification vs. 1,3-Dipolar Cycloaddition Synthetic Approaches for Preparation of the Fluorescently Labelled Iron(II) Clathrochelates

Author(s): R.A. Selin, V.Y. Chernii, D.V. Kryvorotenko, A. Mokhir, Y.Z. Voloshin
Published in: Macroheterocycles, Issue 14(1), 2021, Page(s) 94-100, ISSN 1998-9539
Publisher: Ivanovo State University of Chemistry and Technology
DOI: 10.6060/mhc201230v

Expanding manganese(IV) aqueous chemistry: unusually stable water-soluble hexahydrazide clathrochelate complexes.

Author(s): Sergii I. Shylin; Sergii I. Shylin; James Pogrebetsky; Alina O. Husak; Dmytro Bykov; Andriy Mokhir; Frank Hampel; Sergiu Shova; Andrew Ozarowski; Elzbieta Gumienna-Kontecka; Igor O. Fritsky
Published in: Chemical Communication, Issue 57 (84), 2021, Page(s) 11060-11063, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc04870h

Crystal structure of a water oxidation catalyst solvate with composition (NH4)2[FeIV(L-6H)]·- 3CH3COOH (L = clathrochelate ligand)

Author(s): Plutenko, Maksym O.; Shylin, Sergii I.; Shova, Sergiu; Blinder, Aleksander V.; Fritsky, Igor O.
Published in: Acta Crystallographica Section E: Crystallographic Commun., Issue E80, 2024, Page(s) 25-28, ISSN 2056-9890
Publisher: International Union of Crystallography
DOI: 10.1107/S2056989023010514