Chiroptical, optical and magnetic probes for protein sensing based on cage metal complexes

Livrables

Three research paper on the topic of WP3
Internet website of the project

Internet website highlighting the research activity of the project and providing information about its progress

Three research papers on the topic of WP2
Two research papers on the topic of WP1

Publications

Spectroelectrochemical Properties and Catalytic Activity in Cyclohexane Oxidation of the Hybrid Zr/Hf-Phthalocyaninate-Capped Nickel(II) and Iron(II) tris-Pyridineoximates and Their Precursors.

Auteurs: Yan Z. Voloshin; Semyon V. Dudkin; Svetlana A. Belova; Daniel Gherca; Dumitru Samohvalov; Corina-Mihaela Manta; Maria-Andreea Lungan; Samuel M. Meier-Menches; Peter Rapta; Denisa Darvasiová; Michal Malček; Armando J. L. Pombeiro; Luísa M. D. R. S. Martins; Vladimir B. Arion
Publié dans: Molecules, Numéro 26 (17), 2021, Page(s) 336, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020336

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Auteurs: Insa Klemt; Oleg Varzatskii; Roman Selin; Serhii Vakarov; Vladyslava Kovalska; Galyna Bila; Rostyslav Bilyy; Yan Voloshin; Itziar Cossío Cuartero; Andrés Hidalgo; Benjamin Frey; Ina Becker; Bernhard Friedrich; Rainer Tietze; Ralf P. Friedrich; Christoph Alexiou; Elena-Laura Ursu; Alexandru Rotaru; Iris Solymosi; M. Eugenia Pérez-Ojeda; Andriy Mokhir
Publié dans: J. Am. Chem. Soc., Numéro 145 (40), 2023, Page(s) 22252-22264, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.3c08827

Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

Auteurs: Hyeon Joo Yoo, Yibin Liu, Lei Wang, Maria-Luisa Schubert, Jean-Marc Hoffmann, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Andriy Mokhir, Michael Schmitt, Leopold Sellner
Publié dans: International Journal of Molecular Sciences, Numéro 20/10, 2019, Page(s) 2469, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20102469

Inhibition of DNA synthesis in the transcription system of Taq DNA polymerase by various iron and cobalt(II) tris-dioximate clathrochelates: In vitro study and X-ray structure of leader inhibitors, the carboxyl-terminated macrobicyclic complexes☆

Auteurs: Oleg A. Varzatskii, Anna V. Vologzhanina, Valentin V. Novikov, Serhii V. Vakarov, Ruslan V. Oblap, Yan Z. Voloshin
Publié dans: Inorganica Chimica Acta, Numéro 482, 2018, Page(s) 90-98, ISSN 0020-1693
Éditeur: Elsevier BV
DOI: 10.1016/j.ica.2018.06.004

A cancer specific oxaliplatin-releasing Pt( iv )-prodrug

Auteurs: Viktor Reshetnikov, Anton Arkhypov, Purushottam Reddy Julakanti, Andriy Mokhir
Publié dans: Dalton Transactions, Numéro 47/19, 2018, Page(s) 6679-6682, ISSN 1477-9226
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8dt01458b

Crystal structure and Hirshfeld surface analysis of poly[[bis-[μ4-N,N'-(1,3,5-oxadiazinane-3,5-di-yl)bis(carbamoyl-methano-ato)]nickel(II)tetra-potassium] 4.8-hydrate].

Auteurs: Maksym O. Plutenko; Matti Haukka; Alina O. Husak; Turganbay S. Iskenderov; Nurullo U. Mulloev
Publié dans: Acta Crystallographica Section E: Crystallographic Communications, Numéro 2, 2021, Page(s) 298-304, ISSN 2056-9890
Éditeur: International Union of Crystallography
DOI: 10.1107/s205698902100205x

Crystal structure and Hirshfeld surface analysis of poly[[tetraaqua(μ-1,3,4,7,8,10,12,13,16,17,19,22-dodecaazatetracyclo[8.8.4.1<sup>3,17</sup>.1<sup>8,12</sup>]tetracosane-5,6,14,15,20,21-hexaonato)iron(IV)dilithium] tetrahydrate]

Auteurs: Maksym O. Plutenko; Sergiu Shova; Vadim A. Pavlenko; Irina A. Golenya; Igor O. Fritsky
Publié dans: Acta Crystallographica Section E: Crystallographic Commun., Numéro E79, 2023, Page(s) 1059-1062, ISSN 2056-9890
Éditeur: International Union of Crystallography
DOI: 10.1107/s2056989023008587

Synthesis and spectral characterization of the first fluorescein-tagged iron(II) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake

Auteurs: Roman O. Selin; Insa Klemt; Viktor Chernii; Mykhaylo Yu. Losytskyy; Svitlana Chernii; Andrzej Mular; Elzbieta Gumienna-Kontecka; Vladyslava B. Kovalska; Yan Z. Voloshin; Anna V. Vologzhanina; Pavel V. Dorovatovskii; Andriy Mokhir
Publié dans: RSC ADVANCES, Numéro 6, 2021, Page(s) 8163-8177, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0ra10502c

Induced chirality of cage metal complexes switched by their supramolecular and covalent binding

Auteurs: Vladyslava B. Kovalska, Serhii V. Vakarov, Marina V. Kuperman, Mykhaylo Y. Losytskyy, Elzbieta Gumienna-Kontecka, Yan Z. Voloshin, Oleg A. Varzatskii
Publié dans: Dalton Transactions, Numéro 47/4, 2018, Page(s) 1036-1052, ISSN 1477-9226
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7dt03731g

Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils

Auteurs: Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir
Publié dans: Frontiers in Immunology, Numéro 9, 2018, Page(s) 1827, ISSN 1664-3224
Éditeur: FrontiersMediaSA
DOI: 10.3389/fimmu.2018.01827

Synthesis and characterization of an Fe( i ) cage complex with high stability towards strong H-acids

Auteurs: Yan Z. Voloshin, Valentin V. Novikov, Yulia V. Nelyubina, Alexander S. Belov, Dmitrii M. Roitershtein, Anton Savitsky, Andriy Mokhir, Jörg Sutter, Matthias E. Miehlich, Karsten Meyer
Publié dans: Chemical Communications, Numéro 54/28, 2018, Page(s) 3436-3439, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7cc09611a

Extension and functionalization of an encapsulating macrobicyclic ligand using palladium-catalyzed Suzuki–Miyaura and Sonogashira reactions of iron( ii ) dihalogenoclathrochelates with inherent halogen substituents

Auteurs: Irina N. Denisenko, Oleg A. Varzatskii, Roman A. Selin, Alexander S. Belov, Ekaterina G. Lebed, Anna V. Vologzhanina, Yan V. Zubavichus, Yan Z. Voloshin
Publié dans: RSC Advances, Numéro 8/24, 2018, Page(s) 13578-13587, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8ra01819g

The molecular design of cage metal complexes for biological applications: pathways of the synthesis, and X-ray structures of a series of new N 2 -, S 2 - and O 2 -alicyclic iron( ii ) di- and tetrachloroclathrochelates

Auteurs: Genrikh E. Zelinskii, Alexander S. Belov, Irina G. Belaya, Anna V. Vologzhanina, Valentin V. Novikov, Oleg A. Varzatskii, Yan Z. Voloshin
Publié dans: New Journal of Chemistry, Numéro 42/1, 2018, Page(s) 56-66, ISSN 1144-0546
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7nj03051g

Very Large Magnetic Anisotropy of Cage Cobalt(II) Complexes with a Rigid Cholesteryl Substituent from Paramagnetic NMR Spectroscopy

Auteurs: Alexander A. Pavlov, Svetlana A. Savkina, Alexander S. Belov, Yan Z. Voloshin, Yulia V. Nelyubina, Valentin V. Novikov
Publié dans: ACS Omega, Numéro 3/5, 2018, Page(s) 4941-4946, ISSN 2470-1343
Éditeur: American Chemical Society
DOI: 10.1021/acsomega.8b00772

Efficient visible light-driven water oxidation catalysed by an iron( iv ) clathrochelate complex

Auteurs: Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Fikret Mamedov, Jacinto Sá, Gustav Berggren, Igor O. Fritsky
Publié dans: Chemical Communications, Numéro 55/23, 2019, Page(s) 3335-3338, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9cc00229d

Induced CD of iron( ii ) clathrochelates: sensing of the structural and conformational alterations of serum albumins

Auteurs: Vladyslava Kovalska, Marina Kuperman, Mykhaylo Losytskyy, Serhii Vakarov, Slawomir Potocki, Sergiy Yarmoluk, Yan Voloshin, Oleg Varzatskii, Elzbieta Gumienna-Kontecka
Publié dans: Metallomics, Numéro 11/2, 2019, Page(s) 338-348, ISSN 1756-5901
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8mt00278a

Photoinduced hole transfer from tris(bipyridine)ruthenium dye to a high-valent iron-based water oxidation catalyst

Auteurs: Sergii I. Shylin, Mariia V. Pavliuk, Luca D’Amario, Igor O. Fritsky, Gustav Berggren
Publié dans: Faraday Discussions, Numéro 215, 2019, Page(s) 162-174, ISSN 1359-6640
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8fd00167g

Dicarboxyl-terminated iron( ii ) clathrochelates as ICD-reporters for globular proteins

Auteurs: Vladyslava Kovalska, Serhii Vakarov, Mykhaylo Losytskyy, Marina Kuperman, Nina Chornenka, Yuliya Toporivska, Elzbieta Gumienna-Kontecka, Yan Voloshin, Oleg Varzatskii, Andriy Mokhir
Publié dans: RSC Advances, Numéro 9/42, 2019, Page(s) 24218-24230, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9ra04102h

Chemical design of the heterodifunctionalized iron(II) clathrochelates with terminal biorelevant carboxyl group and reactive triple C≡C bond: Synthesis, structure, redox properties and their stability in various media

Auteurs: Roman A. Selin, Nina V. Chornenka, Viktor Ya. Chernii, Andriy Mokhir, Anna V. Vologzhanina, Alexander S. Belov, Alexander L. Pomadchik, Yan Z. Voloshin
Publié dans: Inorganica Chimica Acta, Numéro 496, 2019, Page(s) 119047, ISSN 0020-1693
Éditeur: Elsevier BV
DOI: 10.1016/j.ica.2019.119047

Pseudomacrobicyclic Phthalocyaninate-Capped Cobalt(III) tris-Pyridineoximates: Template Synthesis, X-Ray Structure and Spectral Characteristics

Auteurs: Svetlana A. Belova (Savkina), Semyon V. Dudkin, Alexander S. Belov, Yulia V. Nelyubina, Valentin V. Novikov, Yan V. Zubavichus, Yan Z. Voloshin
Publié dans: Macroheterocycles, Numéro 12/2, 2019, Page(s) 193-197, ISSN 1998-9539
Éditeur: Ivanovo State University of Chemistry and Technology
DOI: 10.6060/mhc190550d

Sensing of Proteins by ICD Response of Iron(II) Clathrochelates Functionalized by Carboxyalkylsulfide Groups

Auteurs: Mykhaylo Losytskyy, Nina Chornenka, Serhii Vakarov, Samuel M. Meier-Menches, Christopher Gerner, Slawomir Potocki, Vladimir B. Arion, Elzbieta Gumienna-Kontecka, Yan Voloshin, Vladyslava Kovalska
Publié dans: Biomolecules, Numéro 10/12, 2020, Page(s) 1602, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom10121602

SYNTHESIS OF MODYFIED FLUORESCEINE FOR CLICK REACTIONS

Auteurs: Roman Selin, Viktor Chernii, Andriy Mokhir
Publié dans: Ukrainian Chemistry Journal, Numéro 86/3, 2020, Page(s) 3-8, ISSN 0041-6045
Éditeur: National'na Akademiya Nauk Ukrainy
DOI: 10.33609/0041-6045.86.3.2020.3-8

Esterification vs. 1,3-Dipolar Cycloaddition Synthetic Approaches for Preparation of the Fluorescently Labelled Iron(II) Clathrochelates

Auteurs: R.A. Selin, V.Y. Chernii, D.V. Kryvorotenko, A. Mokhir, Y.Z. Voloshin
Publié dans: Macroheterocycles, Numéro 14(1), 2021, Page(s) 94-100, ISSN 1998-9539
Éditeur: Ivanovo State University of Chemistry and Technology
DOI: 10.6060/mhc201230v

Expanding manganese(IV) aqueous chemistry: unusually stable water-soluble hexahydrazide clathrochelate complexes.

Auteurs: Sergii I. Shylin; Sergii I. Shylin; James Pogrebetsky; Alina O. Husak; Dmytro Bykov; Andriy Mokhir; Frank Hampel; Sergiu Shova; Andrew Ozarowski; Elzbieta Gumienna-Kontecka; Igor O. Fritsky
Publié dans: Chemical Communication, Numéro 57 (84), 2021, Page(s) 11060-11063, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1cc04870h

Crystal structure of a water oxidation catalyst solvate with composition (NH4)2[FeIV(L-6H)]·- 3CH3COOH (L = clathrochelate ligand)

Auteurs: Plutenko, Maksym O.; Shylin, Sergii I.; Shova, Sergiu; Blinder, Aleksander V.; Fritsky, Igor O.
Publié dans: Acta Crystallographica Section E: Crystallographic Commun., Numéro E80, 2024, Page(s) 25-28, ISSN 2056-9890
Éditeur: International Union of Crystallography
DOI: 10.1107/S2056989023010514

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