Skip to main content

IMaging-based CUSTOMised EYE diagnostics

Objective

Prevalent eye diseases, such as glaucoma, keratoconus, refractive errors, cataract, myopia and presbyopia, affect millions
worldwide, and only in Europe represent over €20 billion annual cost to society. Current screening tools rely on
morphological biomarkers based on corneal shape and optics, yet differences in biomechanical properties underlie and
precede disease development (i.e. keratoconus, ectasia risk) or affect standard markers (i.e. intraocular pressure in
glaucoma). IMCUSTOMEYE will develop new diagnostic paradigms for these vision-threatening conditions, with a direct
impact on their treatment. We will deploy new compact, easy-to-use, label-free non-invasive imaging-based instrumentation
for direct measurement of corneal biomechanical properties in patients. The technology is based on imaging concepts
brought from other disciplines into ophthalmology and, for the first time, applied in patients in vivo. Dynamic corneal imaging
based on air-puff stimulated Optical Coherence Tomography corneal deformation and acoustic stimulated phase sensitive
and nanosensitive Optical Coherence Tomography corneal vibrography will be coupled to corneal mechanical models to
estimate corneal elasticity and viscoelasticity parameters (isolated from other factors). Corneal biomechanical properties will
be used as biomarkers for in-depth diagnosis of keratoconus and ectasia risk, and to provide accurate estimates of
intraocular pressure in glaucoma diagnosis. Clinical validations in ophthalmology hospitals will demonstrate the diagnostic and treatment predictive potential of the customised optical and biomechanical eye models from patient-specific enabled by
the new technology. IMCUSTOMEYE will contribute to more effective, customised treatment of eye diseases and to
reinforce industrial leadership in the area of diagnostic imaging in ophthalmology.

Field of science

  • /natural sciences/physical sciences/optics
  • /medical and health sciences/clinical medicine/ophthalmology/glaucoma
  • /medical and health sciences/clinical medicine/ophthalmology

Call for proposal

H2020-ICT-2017-1
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 1 457 423,75

Participants (10)

THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 824 881,25
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 820 413,75
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 979 000
Address
Kasprzaka 44/52
01224 Warszawa
Activity type
Higher or Secondary Education Establishments
INSTITUTO OFTALMOLOGICO FERNANDEZ-VEGA SL
Spain
EU contribution
€ 261 121
Address
Av Doctores Fernando Vega S/n
33012 Oviedo Asturias
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 160 918,56
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
IROC SCIENCE TO INNOVATION AG
Switzerland
EU contribution
€ 463 804,25
Address
Bahnhofstrasse 21
6300 Zug
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OCULUS OPTIKGERATE GESELLSCHAFT MITBESCHRANKTER HAFTUNG
Germany
EU contribution
€ 286 328,88
Address
Munchholzhauser Strase 29
35582 Wetzlar
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
2 EYES VISION SL
Spain
EU contribution
€ 157 535
Address
Calle Badalona 17 2 Derecha
28034 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OPTIMO MEDICAL AG
Switzerland
EU contribution
€ 280 612,50
Address
Robert Walser Platz 7
2503 Biel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 239 630,19
Address
City Road 162
EC1V 2PD London
Activity type
Research Organisations