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IMaging-based CUSTOMised EYE diagnostics

Objective

Prevalent eye diseases, such as glaucoma, keratoconus, refractive errors, cataract, myopia and presbyopia, affect millions
worldwide, and only in Europe represent over €20 billion annual cost to society. Current screening tools rely on
morphological biomarkers based on corneal shape and optics, yet differences in biomechanical properties underlie and
precede disease development (i.e. keratoconus, ectasia risk) or affect standard markers (i.e. intraocular pressure in
glaucoma). IMCUSTOMEYE will develop new diagnostic paradigms for these vision-threatening conditions, with a direct
impact on their treatment. We will deploy new compact, easy-to-use, label-free non-invasive imaging-based instrumentation
for direct measurement of corneal biomechanical properties in patients. The technology is based on imaging concepts
brought from other disciplines into ophthalmology and, for the first time, applied in patients in vivo. Dynamic corneal imaging
based on air-puff stimulated Optical Coherence Tomography corneal deformation and acoustic stimulated phase sensitive
and nanosensitive Optical Coherence Tomography corneal vibrography will be coupled to corneal mechanical models to
estimate corneal elasticity and viscoelasticity parameters (isolated from other factors). Corneal biomechanical properties will
be used as biomarkers for in-depth diagnosis of keratoconus and ectasia risk, and to provide accurate estimates of
intraocular pressure in glaucoma diagnosis. Clinical validations in ophthalmology hospitals will demonstrate the diagnostic and treatment predictive potential of the customised optical and biomechanical eye models from patient-specific enabled by
the new technology. IMCUSTOMEYE will contribute to more effective, customised treatment of eye diseases and to
reinforce industrial leadership in the area of diagnostic imaging in ophthalmology.

Call for proposal

H2020-ICT-2016-2017

See other projects for this call

Sub call

H2020-ICT-2017-1

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution
€ 1 579 404,04
Address
Calle Serrano 117
28006 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (11)

THE UNIVERSITY OF LIVERPOOL
United Kingdom
Net EU contribution
€ 853 514,14
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

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Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
Net EU contribution
€ 820 413,75
Address
University Road
H91 Galway

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 1 034 070,91
Address
Kasprzaka 44/52
01224 Warszawa

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUTO OFTALMOLOGICO FERNANDEZ-VEGA SL
Spain
Net EU contribution
€ 209 211,63
Address
Av Doctores Fernando Vega S/n
33012 Oviedo Asturias

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Principado de Asturias Asturias
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 89 662,12
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 160 918,56
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
City Road 162
EC1V 2PD London

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Region
London Inner London — East Haringey and Islington
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IROC SCIENCE TO INNOVATION AG
Switzerland
Net EU contribution
€ 463 804,25
Address
Bahnhofstrasse 21
6300 Zug

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 198 773,25
OCULUS OPTIKGERATE GESELLSCHAFT MITBESCHRANKTER HAFTUNG
Germany
Net EU contribution
€ 229 063,10
Address
Munchholzhauser Strase 29
35582 Wetzlar

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Region
Gießen Lahn-Dill-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 98 169,90
2 EYES VISION SL
Spain
Net EU contribution
€ 186 167,89
Address
Calle Badalona 17 2 Derecha
28034 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 79 786,24
OPTIMO MEDICAL AG
Switzerland
Net EU contribution
€ 280 612,50
Address
Robert Walser Platz 7
2503 Biel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 120 262,50
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
Net EU contribution
€ 114 488,36
Address
City Road 162
EC1V 2PD London

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Region
London Inner London — East Haringey and Islington
Activity type
Research Organisations
Non-EU contribution
€ 0,00