Deliverables Documents, reports (9) Report on diagnostic value of imaging tool for keratoconus and IOP-related glaucoma Report on diagnostic value of imaging tool for keratoconus and IOPrelated glaucoma including clinical study on keratoconus keratoconus suspects crosslinked keratoconus and glaucoma patients retrieved viscoelastic parameters and IOP Report of viscoelastic parameters in first sets of eyes Report of viscoelastic parameters in first sets of eyes including enucleated eyes normal eyes in vivo and 2D keratoconus and CXL eyes Internet outreach and social media The domain httpwwwimcustomeyeeu has been acquired for the IMCUSTOMEYE project and will be updated by the coordinating team with public information from research reports and activities related with the project Announcements will be distributed through a linked blog and a dedicated twitter account Flyers presenting research to the public will be printed and distributed information for the clinician and patient will be generated and disseminated through the web and social media Report demonstrating the technique on enucleated eyes Corneal deformation imaging in porcine corneas ex vivo normal after IOPreducing drops and crosslinking and human donor eyes ex vivo Report of effect of the impact treatment parameters on simulated outcomes Report of effect of the impact treatment parameters on simulated outcomes for intracorneal implant treatments cataracts and corneal refractive surgery Report demonstrating the techniques in human eyes in vivo Corneal deformation imaging in normal eyes in vivo Dissemination Plan A Dissemination Plan will be prepared during the first 4 months of the project identifying the most appropriate communication channels and tools for dissemination of key research findings related to all workpackages to a wide range of audiences Innovation management report Innovation management report This activity will be in coordination with WP8 Documentation of dynamic OCT prototype Report with documents specifications validation on subjects and protocols for operation Websites, patent fillings, videos etc. (4) Video clips Short 2 min video clips will be made showcasing the results for the research and clinical work packages after IP protection has been secured The videos will be aimed at the general public and will serve as explanatory material to potential investors in a commercialisation phaseMonths 12 24 and 36 Patient and general public engagement Each team member will hold an open door day to present the research to general public high school students or patient groups UCL will capitalise on the Patient Engagement Initiatives at Moorfields Eye Hospital and IOFV An IMCUSTOMEYE project joint event happening simultaneously at all sites is planned for the European Researchers Night in September 2018 Press releases and media coverage Publications in high impact journals and relevant achievements will be presented in press releases both institutional and newsletters from academic and professional societies where project members have influence Media coverage television radio press podcasts is expected following press releases Special attention will be made to seek broadcasting by European media such as EuronewsMonths 18 30 and 42 Project intranet in operation The established SharePoint site will be launched with areas for each work package internal management document tracking and internal communication Demonstrators, pilots, prototypes (4) Functional acoustic stimulation vibrational ps-nsOCT Acoustic stimulation module adapted OCT platforms Fabricated dynamic OCT prototype Physical compact device with mounted elements OCT platform for integration into miniaturised device and testing Functional 3D air-puff OCT imaging experimental systems Integrated hardware and software control in OCT for acquisition of 3D corneal deformation images synchronised to airpuff Publications Peer reviewed articles (13) Nanosensitive optical coherence tomography to assess wound healing within the cornea Author(s): Cerine Lal, Sergey Alexandrov, Sweta Rani, Yi Zhou, Thomas Ritter, Martin Leahy Published in: Biomedical Optics Express, Issue 11/7, 2020, Page(s) 3407, ISSN 2156-7085 Publisher: The Optical Society DOI: 10.1364/BOE.389342 Corneal Properties of Keratoconus Based on Scheimpflug Light Intensity Distribution Author(s): Alejandra Consejo, Karolina Glawdecka, Karol Karnowski, Jedrzej Solarski, Jos J. Rozema, Maciej Wojtkowski, D. Robert Iskander Published in: Investigative Opthalmology & Visual Science, Issue 60/8, 2019, Page(s) 3197, ISSN 1552-5783 Publisher: ARVO DOI: 10.1167/IOVS.19-26963 Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment Author(s): Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey, Martin Leahy Published in: Journal of Biophotonics, Issue 13/6, 2020, ISSN 1864-063X Publisher: Wiley - VCH Verlag GmbH & CO. KGaA DOI: 10.1002/jbio.201960234 Corneal tissue properties following scleral lens wear using Scheimpflug imaging Author(s): Alejandra Consejo, David Alonso‐Caneiro, Maciej Wojtkowski, Stephen J Vincent Published in: Ophthalmic and Physiological Optics, 2020, ISSN 0275-5408 Publisher: Blackwell Publishing Inc. DOI: 10.1111/opo.12710 Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography Author(s): Nandan Das, Alexandrov Sergey, Yi Zhou, Katie E. Gilligan, Róisín M. Dwyer, Martin Leahy Published in: Nanoscale Advances, Issue 2/7, 2020, Page(s) 2853-2858, ISSN 2516-0230 Publisher: Royal Society of Chemistry DOI: 10.1039/D0NA00371A The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients Author(s): Marcella Q. Salomão, Ana Luisa Hofling-Lima, Louise Pellegrino Gomes Esporcatte, Bernardo Lopes, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Nelson Sena, Guilherme Simões Luz Hilgert, Renato Ambrósio Published in: International Journal of Environmental Research and Public Health, Issue 17/6, 2020, Page(s) 2113, ISSN 1660-4601 Publisher: MDPI DOI: 10.3390/ijerph17062113 Keratoconus Detection Based on a Single Scheimpflug Image Author(s): Alejandra Consejo, Jedrzej Solarski, Karol Karnowski, Jos J Rozema, Maciej Wojtkowski, D. Robert Iskander Published in: Translational Vision Science & Technology, Issue 9/7, 2020, Page(s) 36, ISSN 2164-2591 Publisher: ARVO DOI: 10.1167/tvst.9.7.36 Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking Author(s): James A. Germann, Eduardo Martínez-Enríquez, M. Carmen Martínez-García, Irene E. Kochevar, Susana Marcos Published in: Investigative Opthalmology & Visual Science, Issue 61/3, 2020, Page(s) 28, ISSN 1552-5783 Publisher: ARVO DOI: 10.1167/iovs.61.3.28 Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization Author(s): Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy Published in: Applied Physics Letters, Issue 115/12, 2019, Page(s) 121105, ISSN 0003-6951 Publisher: American Institute of Physics DOI: 10.1063/1.5110459 Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis Author(s): Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski Published in: Journal of Biophotonics, Issue 12/2, 2019, Page(s) e201800154, ISSN 1864-063X Publisher: Wiley - VCH Verlag GmbH & CO. KGaA DOI: 10.1002/jbio.201800154 Characterization of cone size and centre in keratoconic corneas Author(s): Ashkan Eliasy, Ahmed Abass, Bernardo T. Lopes, Riccardo Vinciguerra, Haixia Zhang, Paolo Vinciguerra, Renato Ambrósio, Cynthia J. Roberts, Ahmed Elsheikh Published in: Journal of The Royal Society Interface, Issue 17/169, 2020, Page(s) 20200271, ISSN 1742-5689 Publisher: The Royal Society DOI: 10.1098/rsif.2020.0271 Can the Corvis ST Estimate Corneal Viscoelasticity? Author(s): Ahmed Abass, Cynthia J. Roberts, Bernardo Lopes, Ashkan Eliasy, Riccardo Vinciguerra, Renato Ambrósio, Paolo Vinciguerra, Ahmed Elsheikh, Mathew Francis, Himanshu Matalia, Rudy M.M.A. Nuijts, Bart Haex, Rohit Shetty, Abhijit Sinha Roy Published in: Journal of Refractive Surgery, Issue 36/5, 2020, Page(s) 346-347, ISSN 1081-597X Publisher: Slack, Inc. DOI: 10.3928/1081597x-20200212-04 Determination of Corneal Biomechanical Behavior in-vivo for Healthy Eyes Using CorVis ST Tonometry: Stress-Strain Index Author(s): Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Bernardo T. Lopes, Ahmed Abass, Paolo Vinciguerra, Renato Ambrósio Jr., Cynthia J. Roberts, Ahmed Elsheikh Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185 Publisher: Frontiers DOI: 10.3389/fbioe.2019.00105 Conference proceedings (13) Investigation of the corneal frequency response to modulated sound excitation. Author(s): J. S. Birkenfeld; A. Curatolo; A. Nolan; R. McAuley; A. Abass; A. Eliasy; M. Leahy; A. Elsheikh; S. Marcos Published in: Investigative Ophthalmology & Visual Science, 2020 Publisher: ARVO Assessing collagen microstructural changes in an ex vivo keratoconic eye model with Stokes polarization-sensitive optical coherence tomography Author(s): N. Uribe-Patarroyo; J. Sophie Birkenfeld; A. Curatolo; T. M. Cannon; J. Germann; M. Villiger; S. Marcos; B. E. Bouma Published in: Investigative Ophthalmology & Visual Science, 2020 Publisher: ARVO Scleral cross-linking using Rose Bengal-Green Light Author(s): L. I. Villegas Lopez; D. Bronte; J. Germann; S. Marcos Published in: Investigative Ophthalmology & Visual Science, 2020 Publisher: ARVO Customised optical coherence tomography system for corneal deformation imaging on multiple meridians Author(s): A. Curatolo, J. Birkenfeld, J. A. Germann, A. de Castro, G. Muralidharan, M. Velasco, E. Martínez, and S. Marcos Published in: 2018 Publisher: XII Reunión Nacional de Óptica Assessment of ocular mechanical resonances using phase-sensitive OCT and frequency-domain air puff stimulation Author(s): J. Birkenfeld, A. Ramier, B. Tavakol, S. Marcos and S. Yun Published in: 2018 Publisher: ARVO Annual Meeting 2018 Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method Author(s): Elsheikh, A., Eliasy, A., Chen, K. J., & Vinciguerra, R. Published in: 2018 Publisher: 8th World Congress of Biomechanics Fluid Structure Interaction (FSI) Simulation Of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD) Author(s): Maklad, O., Theofilis, V., & Elsheikh, A. Published in: 2018 Publisher: ICCFD10 - Tenth International Conference on CFD Intraocular Pressure Measurement Pre- and Post Refractive Surgery Using GAT and CorVis ST bIOP Algorithm Author(s): Eliasy, A., Elsheikh, A., & Chen, K. -J. Published in: 2018 Publisher: 6th European Conference on Computational Mechanics (ECCM 6) 7th European Conference on Computational Fluid Dynamics (ECFD 7) Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus Author(s): Eliasy, A., Chen, K. J., Vinciguerra, R., & Elsheikh, A. Published in: 2018 Publisher: 8th World Congress of Biomechanics Microscopic organization of corneal collagen: Comparison between keratoconic and normal human corneas Author(s): J. Germann, E. Martinez-Enriquez, S. Bueno, A. Mohamed, S. Nandyala, S. Chaurasia, S. Marcos Published in: Investigative Ophthalmology & Visual Science, 2020 Publisher: ARVO Probing temporal structural changes within cornea using 200 kHz swept source nano sensitive optical coherence tomography (nsOCT) Author(s): Cerine Lal, Sergey Alexandrov, Sweta Rani, Thomas Ritter, Martin Leahy Published in: Dynamics and Fluctuations in Biomedical Photonics XVII, 2020, Page(s) 7, ISBN 9781510632424 Publisher: SPIE DOI: 10.1117/12.2553024 Customized swept-source optical coherence tomography system for air-puff induced corneal deformation imaging on multiple meridians (Conference Presentation) Author(s): Andrea Curatolo, Judith Birkenfeld, Eduardo Martínez, James A. Germann, Jesús Palací, Daniel Pascual, Geethika Muralidharan, Jedrzej Solarski, Karol Karnowski, Maciej Wojtkowski, Susana Marcos Published in: Ophthalmic Technologies XXX, 2020, Page(s) 30, ISBN 9781510632004 Publisher: SPIE DOI: 10.1117/12.2546050 Detecting deformation asymmetries on multiple meridians in an ex vivo keratoconic eye model Author(s): Andrea Curatolo; Judith Sophie Birkenfeld; Eduardo Martinez-Enriquez; James Germann; Jesus Palaci; Daniel Pascual; Geethika Muralidharan; Ashkan Eliasy; Ahmed Abass; Jedrzej Solarski; Karol Karnowski; Maciej Wojtkowski; Ahmed Elsheikh; Susana Marcos Published in: Investigative Ophthalmology & Visual Science, 2020 Publisher: ARVO Non-peer reviewed articles (1) Künstliche Intelligenz zur Entwicklung von Screening-Parametern im Bereich der kornealen Biomechanik Author(s): Sven Reisdorf Published in: Klinische Monatsblätter für Augenheilkunde, Issue 236/12, 2019, Page(s) 1423-1427, ISSN 0023-2165 Publisher: Georg Thieme Verlag DOI: 10.1055/a-1032-8559 Other (1) Background Subtraction Vs Highpass filtering in phase sensitive Optica Coherence Tomography Author(s): Ryan McAuley, A. Nolan, K. Larin, M. Singh, S. Alexandrov, Martin Leahy Published in: Bi-annual Biophotonics and Imaging Summer School (BIGSS'18), 2018 Publisher: University of Galway Monographic books (1) Biomechanics of the Eye _ Chapter 6. Material properties of the human cornea: anisotropy Author(s): Eliasy, A., Zhou, D., Studer, H., Boote, C., & Elsheikh, A. Published in: Material properties of the human cornea: anisotropy, 2018 Publisher: Kugler Publications Intellectual Property Rights Patent (16) METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): UNIVERSITY OF GALWAY METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS Application/Publication number: 20 382178 Date: 2018-04-30 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS Application/Publication number: 20 382178 Date: 2018-04-30 Applicant(s): THE UNIVERSITY OF LIVERPOOL SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): THE UNIVERSITY OF LIVERPOOL METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): THE UNIVERSITY OF LIVERPOOL SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): THE UNIVERSITY OF LIVERPOOL SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS Application/Publication number: 20 382178 Date: 2018-04-30 Applicant(s): THE UNIVERSITY OF LIVERPOOL METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382178 Date: 2020-03-11 Applicant(s): UNIVERSITY OF GALWAY SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS Application/Publication number: 20 382178 Date: 2018-04-30 Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE Application/Publication number: 20 382067 Date: 2020-02-02 Applicant(s): THE UNIVERSITY OF LIVERPOOL Searching for OpenAIRE data... 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