IMaging-based CUSTOMised EYE diagnostics

Livrables

Report on diagnostic value of imaging tool for keratoconus and IOP-related glaucoma

Report on diagnostic value of imaging tool for keratoconus and IOPrelated glaucoma including clinical study on keratoconus keratoconus suspects crosslinked keratoconus and glaucoma patients retrieved viscoelastic parameters and IOP

Report of viscoelastic parameters in first sets of eyes

Report of viscoelastic parameters in first sets of eyes including enucleated eyes normal eyes in vivo and 2D keratoconus and CXL eyes

Internet outreach and social media

The domain httpwwwimcustomeyeeu has been acquired for the IMCUSTOMEYE project and will be updated by the coordinating team with public information from research reports and activities related with the project Announcements will be distributed through a linked blog and a dedicated twitter account Flyers presenting research to the public will be printed and distributed information for the clinician and patient will be generated and disseminated through the web and social media

Report demonstrating the technique on enucleated eyes

Corneal deformation imaging in porcine corneas ex vivo normal after IOPreducing drops and crosslinking and human donor eyes ex vivo

Report of effect of the impact treatment parameters on simulated outcomes

Report of effect of the impact treatment parameters on simulated outcomes for intracorneal implant treatments cataracts and corneal refractive surgery

Report demonstrating the techniques in human eyes in vivo

Corneal deformation imaging in normal eyes in vivo

Dissemination Plan

A Dissemination Plan will be prepared during the first 4 months of the project identifying the most appropriate communication channels and tools for dissemination of key research findings related to all workpackages to a wide range of audiences

Innovation management report

Innovation management report This activity will be in coordination with WP8

Documentation of dynamic OCT prototype

Report with documents specifications validation on subjects and protocols for operation

Video clips

Short 2 min video clips will be made showcasing the results for the research and clinical work packages after IP protection has been secured The videos will be aimed at the general public and will serve as explanatory material to potential investors in a commercialisation phaseMonths 12 24 and 36

Patient and general public engagement

Each team member will hold an open door day to present the research to general public high school students or patient groups UCL will capitalise on the Patient Engagement Initiatives at Moorfields Eye Hospital and IOFV An IMCUSTOMEYE project joint event happening simultaneously at all sites is planned for the European Researchers Night in September 2018

Press releases and media coverage

Publications in high impact journals and relevant achievements will be presented in press releases both institutional and newsletters from academic and professional societies where project members have influence Media coverage television radio press podcasts is expected following press releases Special attention will be made to seek broadcasting by European media such as EuronewsMonths 18 30 and 42

Project intranet in operation

The established SharePoint site will be launched with areas for each work package internal management document tracking and internal communication

Functional acoustic stimulation vibrational ps-nsOCT

Acoustic stimulation module adapted OCT platforms

Fabricated dynamic OCT prototype

Physical compact device with mounted elements

OCT platform for integration into miniaturised device and testing
Functional 3D air-puff OCT imaging experimental systems

Integrated hardware and software control in OCT for acquisition of 3D corneal deformation images synchronised to airpuff

Publications

Nanosensitive optical coherence tomography to assess wound healing within the cornea

Auteurs: Cerine Lal, Sergey Alexandrov, Sweta Rani, Yi Zhou, Thomas Ritter, Martin Leahy
Publié dans: Biomedical Optics Express, Numéro 11/7, 2020, Page(s) 3407, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/BOE.389342

Corneal Properties of Keratoconus Based on Scheimpflug Light Intensity Distribution

Auteurs: Alejandra Consejo, Karolina Glawdecka, Karol Karnowski, Jedrzej Solarski, Jos J. Rozema, Maciej Wojtkowski, D. Robert Iskander
Publié dans: Investigative Opthalmology & Visual Science, Numéro 60/8, 2019, Page(s) 3197, ISSN 1552-5783
Éditeur: ARVO
DOI: 10.1167/IOVS.19-26963

Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment

Auteurs: Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey, Martin Leahy
Publié dans: Journal of Biophotonics, Numéro 13/6, 2020, ISSN 1864-063X
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960234

Corneal tissue properties following scleral lens wear using Scheimpflug imaging

Auteurs: Alejandra Consejo, David Alonso‐Caneiro, Maciej Wojtkowski, Stephen J Vincent
Publié dans: Ophthalmic and Physiological Optics, 2020, ISSN 0275-5408
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/opo.12710

Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography

Auteurs: Nandan Das, Alexandrov Sergey, Yi Zhou, Katie E. Gilligan, Róisín M. Dwyer, Martin Leahy
Publié dans: Nanoscale Advances, Numéro 2/7, 2020, Page(s) 2853-2858, ISSN 2516-0230
Éditeur: Royal Society of Chemistry
DOI: 10.1039/D0NA00371A

The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients

Auteurs: Marcella Q. Salomão, Ana Luisa Hofling-Lima, Louise Pellegrino Gomes Esporcatte, Bernardo Lopes, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Nelson Sena, Guilherme Simões Luz Hilgert, Renato Ambrósio
Publié dans: International Journal of Environmental Research and Public Health, Numéro 17/6, 2020, Page(s) 2113, ISSN 1660-4601
Éditeur: MDPI
DOI: 10.3390/ijerph17062113

Keratoconus Detection Based on a Single Scheimpflug Image

Auteurs: Alejandra Consejo, Jedrzej Solarski, Karol Karnowski, Jos J Rozema, Maciej Wojtkowski, D. Robert Iskander
Publié dans: Translational Vision Science & Technology, Numéro 9/7, 2020, Page(s) 36, ISSN 2164-2591
Éditeur: ARVO
DOI: 10.1167/tvst.9.7.36

Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking

Auteurs: James A. Germann, Eduardo Martínez-Enríquez, M. Carmen Martínez-García, Irene E. Kochevar, Susana Marcos
Publié dans: Investigative Opthalmology & Visual Science, Numéro 61/3, 2020, Page(s) 28, ISSN 1552-5783
Éditeur: ARVO
DOI: 10.1167/iovs.61.3.28

Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization

Auteurs: Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Publié dans: Applied Physics Letters, Numéro 115/12, 2019, Page(s) 121105, ISSN 0003-6951
Éditeur: American Institute of Physics
DOI: 10.1063/1.5110459

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Auteurs: Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski
Publié dans: Journal of Biophotonics, Numéro 12/2, 2019, Page(s) e201800154, ISSN 1864-063X
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800154

Characterization of cone size and centre in keratoconic corneas

Auteurs: Ashkan Eliasy, Ahmed Abass, Bernardo T. Lopes, Riccardo Vinciguerra, Haixia Zhang, Paolo Vinciguerra, Renato Ambrósio, Cynthia J. Roberts, Ahmed Elsheikh
Publié dans: Journal of The Royal Society Interface, Numéro 17/169, 2020, Page(s) 20200271, ISSN 1742-5689
Éditeur: The Royal Society
DOI: 10.1098/rsif.2020.0271

Can the Corvis ST Estimate Corneal Viscoelasticity?

Auteurs: Ahmed Abass, Cynthia J. Roberts, Bernardo Lopes, Ashkan Eliasy, Riccardo Vinciguerra, Renato Ambrósio, Paolo Vinciguerra, Ahmed Elsheikh, Mathew Francis, Himanshu Matalia, Rudy M.M.A. Nuijts, Bart Haex, Rohit Shetty, Abhijit Sinha Roy
Publié dans: Journal of Refractive Surgery, Numéro 36/5, 2020, Page(s) 346-347, ISSN 1081-597X
Éditeur: Slack, Inc.
DOI: 10.3928/1081597x-20200212-04

Determination of Corneal Biomechanical Behavior in-vivo for Healthy Eyes Using CorVis ST Tonometry: Stress-Strain Index

Auteurs: Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Bernardo T. Lopes, Ahmed Abass, Paolo Vinciguerra, Renato Ambrósio Jr., Cynthia J. Roberts, Ahmed Elsheikh
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 7, 2019, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2019.00105

Investigation of the corneal frequency response to modulated sound excitation.

Auteurs: J. S. Birkenfeld; A. Curatolo; A. Nolan; R. McAuley; A. Abass; A. Eliasy; M. Leahy; A. Elsheikh; S. Marcos
Publié dans: Investigative Ophthalmology & Visual Science, 2020
Éditeur: ARVO

Assessing collagen microstructural changes in an ex vivo keratoconic eye model with Stokes polarization-sensitive optical coherence tomography

Auteurs: N. Uribe-Patarroyo; J. Sophie Birkenfeld; A. Curatolo; T. M. Cannon; J. Germann; M. Villiger; S. Marcos; B. E. Bouma
Publié dans: Investigative Ophthalmology & Visual Science, 2020
Éditeur: ARVO

Scleral cross-linking using Rose Bengal-Green Light

Auteurs: L. I. Villegas Lopez; D. Bronte; J. Germann; S. Marcos
Publié dans: Investigative Ophthalmology & Visual Science, 2020
Éditeur: ARVO

Customised optical coherence tomography system for corneal deformation imaging on multiple meridians

Auteurs: A. Curatolo, J. Birkenfeld, J. A. Germann, A. de Castro, G. Muralidharan, M. Velasco, E. Martínez, and S. Marcos
Publié dans: 2018
Éditeur: XII Reunión Nacional de Óptica

Assessment of ocular mechanical resonances using phase-sensitive OCT and frequency-domain air puff stimulation

Auteurs: J. Birkenfeld, A. Ramier, B. Tavakol, S. Marcos and S. Yun
Publié dans: 2018
Éditeur: ARVO Annual Meeting 2018

Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method

Auteurs: Elsheikh, A., Eliasy, A., Chen, K. J., & Vinciguerra, R.
Publié dans: 2018
Éditeur: 8th World Congress of Biomechanics

Fluid Structure Interaction (FSI) Simulation Of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD)

Auteurs: Maklad, O., Theofilis, V., & Elsheikh, A.
Publié dans: 2018
Éditeur: ICCFD10 - Tenth International Conference on CFD

Intraocular Pressure Measurement Pre- and Post Refractive Surgery Using GAT and CorVis ST bIOP Algorithm

Auteurs: Eliasy, A., Elsheikh, A., & Chen, K. -J.
Publié dans: 2018
Éditeur: 6th European Conference on Computational Mechanics (ECCM 6) 7th European Conference on Computational Fluid Dynamics (ECFD 7)

Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus

Auteurs: Eliasy, A., Chen, K. J., Vinciguerra, R., & Elsheikh, A.
Publié dans: 2018
Éditeur: 8th World Congress of Biomechanics

Microscopic organization of corneal collagen: Comparison between keratoconic and normal human corneas

Auteurs: J. Germann, E. Martinez-Enriquez, S. Bueno, A. Mohamed, S. Nandyala, S. Chaurasia, S. Marcos
Publié dans: Investigative Ophthalmology & Visual Science, 2020
Éditeur: ARVO

Probing temporal structural changes within cornea using 200 kHz swept source nano sensitive optical coherence tomography (nsOCT)

Auteurs: Cerine Lal, Sergey Alexandrov, Sweta Rani, Thomas Ritter, Martin Leahy
Publié dans: Dynamics and Fluctuations in Biomedical Photonics XVII, 2020, Page(s) 7, ISBN 9781510632424
Éditeur: SPIE
DOI: 10.1117/12.2553024

Customized swept-source optical coherence tomography system for air-puff induced corneal deformation imaging on multiple meridians (Conference Presentation)

Auteurs: Andrea Curatolo, Judith Birkenfeld, Eduardo Martínez, James A. Germann, Jesús Palací, Daniel Pascual, Geethika Muralidharan, Jedrzej Solarski, Karol Karnowski, Maciej Wojtkowski, Susana Marcos
Publié dans: Ophthalmic Technologies XXX, 2020, Page(s) 30, ISBN 9781510632004
Éditeur: SPIE
DOI: 10.1117/12.2546050

Detecting deformation asymmetries on multiple meridians in an ex vivo keratoconic eye model

Auteurs: Andrea Curatolo; Judith Sophie Birkenfeld; Eduardo Martinez-Enriquez; James Germann; Jesus Palaci; Daniel Pascual; Geethika Muralidharan; Ashkan Eliasy; Ahmed Abass; Jedrzej Solarski; Karol Karnowski; Maciej Wojtkowski; Ahmed Elsheikh; Susana Marcos
Publié dans: Investigative Ophthalmology & Visual Science, 2020
Éditeur: ARVO

Künstliche Intelligenz zur Entwicklung von Screening-Parametern im Bereich der kornealen Biomechanik

Auteurs: Sven Reisdorf
Publié dans: Klinische Monatsblätter für Augenheilkunde, Numéro 236/12, 2019, Page(s) 1423-1427, ISSN 0023-2165
Éditeur: Georg Thieme Verlag
DOI: 10.1055/a-1032-8559

Biomechanics of the Eye _ Chapter 6. Material properties of the human cornea: anisotropy

Auteurs: Eliasy, A., Zhou, D., Studer, H., Boote, C., & Elsheikh, A.
Publié dans: Material properties of the human cornea: anisotropy, 2018
Éditeur: Kugler Publications

Droits de propriété intellectuelle

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Numéro de demande/publication: 20 382178
Date: 2018-04-30

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Numéro de demande/publication: 20 382178
Date: 2018-04-30

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02
Demandeur(s): INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02
Demandeur(s): INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Numéro de demande/publication: 20 382178
Date: 2018-04-30

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382178
Date: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Numéro de demande/publication: 20 382178
Date: 2018-04-30

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Numéro de demande/publication: 20 382067
Date: 2020-02-02

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