IMaging-based CUSTOMised EYE diagnostics

Resultado final

Report on diagnostic value of imaging tool for keratoconus and IOP-related glaucoma

Report on diagnostic value of imaging tool for keratoconus and IOPrelated glaucoma including clinical study on keratoconus keratoconus suspects crosslinked keratoconus and glaucoma patients retrieved viscoelastic parameters and IOP

Report of viscoelastic parameters in first sets of eyes

Report of viscoelastic parameters in first sets of eyes including enucleated eyes normal eyes in vivo and 2D keratoconus and CXL eyes

Internet outreach and social media

The domain httpwwwimcustomeyeeu has been acquired for the IMCUSTOMEYE project and will be updated by the coordinating team with public information from research reports and activities related with the project Announcements will be distributed through a linked blog and a dedicated twitter account Flyers presenting research to the public will be printed and distributed information for the clinician and patient will be generated and disseminated through the web and social media

Report demonstrating the technique on enucleated eyes

Corneal deformation imaging in porcine corneas ex vivo normal after IOPreducing drops and crosslinking and human donor eyes ex vivo

Report of effect of the impact treatment parameters on simulated outcomes

Report of effect of the impact treatment parameters on simulated outcomes for intracorneal implant treatments cataracts and corneal refractive surgery

Report demonstrating the techniques in human eyes in vivo

Corneal deformation imaging in normal eyes in vivo

Dissemination Plan

A Dissemination Plan will be prepared during the first 4 months of the project identifying the most appropriate communication channels and tools for dissemination of key research findings related to all workpackages to a wide range of audiences

Innovation management report

Innovation management report This activity will be in coordination with WP8

Documentation of dynamic OCT prototype

Report with documents specifications validation on subjects and protocols for operation

Video clips

Short 2 min video clips will be made showcasing the results for the research and clinical work packages after IP protection has been secured The videos will be aimed at the general public and will serve as explanatory material to potential investors in a commercialisation phaseMonths 12 24 and 36

Patient and general public engagement

Each team member will hold an open door day to present the research to general public high school students or patient groups UCL will capitalise on the Patient Engagement Initiatives at Moorfields Eye Hospital and IOFV An IMCUSTOMEYE project joint event happening simultaneously at all sites is planned for the European Researchers Night in September 2018

Press releases and media coverage

Publications in high impact journals and relevant achievements will be presented in press releases both institutional and newsletters from academic and professional societies where project members have influence Media coverage television radio press podcasts is expected following press releases Special attention will be made to seek broadcasting by European media such as EuronewsMonths 18 30 and 42

Project intranet in operation

The established SharePoint site will be launched with areas for each work package internal management document tracking and internal communication

Functional acoustic stimulation vibrational ps-nsOCT

Acoustic stimulation module adapted OCT platforms

Fabricated dynamic OCT prototype

Physical compact device with mounted elements

OCT platform for integration into miniaturised device and testing
Functional 3D air-puff OCT imaging experimental systems

Integrated hardware and software control in OCT for acquisition of 3D corneal deformation images synchronised to airpuff

Publicaciones

Nanosensitive optical coherence tomography to assess wound healing within the cornea

Autores: Cerine Lal, Sergey Alexandrov, Sweta Rani, Yi Zhou, Thomas Ritter, Martin Leahy
Publicado en: Biomedical Optics Express, Edición 11/7, 2020, Página(s) 3407, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/BOE.389342

Corneal Properties of Keratoconus Based on Scheimpflug Light Intensity Distribution

Autores: Alejandra Consejo, Karolina Glawdecka, Karol Karnowski, Jedrzej Solarski, Jos J. Rozema, Maciej Wojtkowski, D. Robert Iskander
Publicado en: Investigative Opthalmology & Visual Science, Edición 60/8, 2019, Página(s) 3197, ISSN 1552-5783
Editor: ARVO
DOI: 10.1167/IOVS.19-26963

Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment

Autores: Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey, Martin Leahy
Publicado en: Journal of Biophotonics, Edición 13/6, 2020, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960234

Corneal tissue properties following scleral lens wear using Scheimpflug imaging

Autores: Alejandra Consejo, David Alonso‐Caneiro, Maciej Wojtkowski, Stephen J Vincent
Publicado en: Ophthalmic and Physiological Optics, 2020, ISSN 0275-5408
Editor: Blackwell Publishing Inc.
DOI: 10.1111/opo.12710

Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography

Autores: Nandan Das, Alexandrov Sergey, Yi Zhou, Katie E. Gilligan, Róisín M. Dwyer, Martin Leahy
Publicado en: Nanoscale Advances, Edición 2/7, 2020, Página(s) 2853-2858, ISSN 2516-0230
Editor: Royal Society of Chemistry
DOI: 10.1039/D0NA00371A

The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients

Autores: Marcella Q. Salomão, Ana Luisa Hofling-Lima, Louise Pellegrino Gomes Esporcatte, Bernardo Lopes, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Nelson Sena, Guilherme Simões Luz Hilgert, Renato Ambrósio
Publicado en: International Journal of Environmental Research and Public Health, Edición 17/6, 2020, Página(s) 2113, ISSN 1660-4601
Editor: MDPI
DOI: 10.3390/ijerph17062113

Keratoconus Detection Based on a Single Scheimpflug Image

Autores: Alejandra Consejo, Jedrzej Solarski, Karol Karnowski, Jos J Rozema, Maciej Wojtkowski, D. Robert Iskander
Publicado en: Translational Vision Science & Technology, Edición 9/7, 2020, Página(s) 36, ISSN 2164-2591
Editor: ARVO
DOI: 10.1167/tvst.9.7.36

Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking

Autores: James A. Germann, Eduardo Martínez-Enríquez, M. Carmen Martínez-García, Irene E. Kochevar, Susana Marcos
Publicado en: Investigative Opthalmology & Visual Science, Edición 61/3, 2020, Página(s) 28, ISSN 1552-5783
Editor: ARVO
DOI: 10.1167/iovs.61.3.28

Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization

Autores: Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Publicado en: Applied Physics Letters, Edición 115/12, 2019, Página(s) 121105, ISSN 0003-6951
Editor: American Institute of Physics
DOI: 10.1063/1.5110459

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Autores: Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski
Publicado en: Journal of Biophotonics, Edición 12/2, 2019, Página(s) e201800154, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800154

Characterization of cone size and centre in keratoconic corneas

Autores: Ashkan Eliasy, Ahmed Abass, Bernardo T. Lopes, Riccardo Vinciguerra, Haixia Zhang, Paolo Vinciguerra, Renato Ambrósio, Cynthia J. Roberts, Ahmed Elsheikh
Publicado en: Journal of The Royal Society Interface, Edición 17/169, 2020, Página(s) 20200271, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2020.0271

Can the Corvis ST Estimate Corneal Viscoelasticity?

Autores: Ahmed Abass, Cynthia J. Roberts, Bernardo Lopes, Ashkan Eliasy, Riccardo Vinciguerra, Renato Ambrósio, Paolo Vinciguerra, Ahmed Elsheikh, Mathew Francis, Himanshu Matalia, Rudy M.M.A. Nuijts, Bart Haex, Rohit Shetty, Abhijit Sinha Roy
Publicado en: Journal of Refractive Surgery, Edición 36/5, 2020, Página(s) 346-347, ISSN 1081-597X
Editor: Slack, Inc.
DOI: 10.3928/1081597x-20200212-04

Determination of Corneal Biomechanical Behavior in-vivo for Healthy Eyes Using CorVis ST Tonometry: Stress-Strain Index

Autores: Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Bernardo T. Lopes, Ahmed Abass, Paolo Vinciguerra, Renato Ambrósio Jr., Cynthia J. Roberts, Ahmed Elsheikh
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 7, 2019, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2019.00105

Investigation of the corneal frequency response to modulated sound excitation.

Autores: J. S. Birkenfeld; A. Curatolo; A. Nolan; R. McAuley; A. Abass; A. Eliasy; M. Leahy; A. Elsheikh; S. Marcos
Publicado en: Investigative Ophthalmology & Visual Science, 2020
Editor: ARVO

Assessing collagen microstructural changes in an ex vivo keratoconic eye model with Stokes polarization-sensitive optical coherence tomography

Autores: N. Uribe-Patarroyo; J. Sophie Birkenfeld; A. Curatolo; T. M. Cannon; J. Germann; M. Villiger; S. Marcos; B. E. Bouma
Publicado en: Investigative Ophthalmology & Visual Science, 2020
Editor: ARVO

Scleral cross-linking using Rose Bengal-Green Light

Autores: L. I. Villegas Lopez; D. Bronte; J. Germann; S. Marcos
Publicado en: Investigative Ophthalmology & Visual Science, 2020
Editor: ARVO

Customised optical coherence tomography system for corneal deformation imaging on multiple meridians

Autores: A. Curatolo, J. Birkenfeld, J. A. Germann, A. de Castro, G. Muralidharan, M. Velasco, E. Martínez, and S. Marcos
Publicado en: 2018
Editor: XII Reunión Nacional de Óptica

Assessment of ocular mechanical resonances using phase-sensitive OCT and frequency-domain air puff stimulation

Autores: J. Birkenfeld, A. Ramier, B. Tavakol, S. Marcos and S. Yun
Publicado en: 2018
Editor: ARVO Annual Meeting 2018

Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method

Autores: Elsheikh, A., Eliasy, A., Chen, K. J., & Vinciguerra, R.
Publicado en: 2018
Editor: 8th World Congress of Biomechanics

Fluid Structure Interaction (FSI) Simulation Of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD)

Autores: Maklad, O., Theofilis, V., & Elsheikh, A.
Publicado en: 2018
Editor: ICCFD10 - Tenth International Conference on CFD

Intraocular Pressure Measurement Pre- and Post Refractive Surgery Using GAT and CorVis ST bIOP Algorithm

Autores: Eliasy, A., Elsheikh, A., & Chen, K. -J.
Publicado en: 2018
Editor: 6th European Conference on Computational Mechanics (ECCM 6) 7th European Conference on Computational Fluid Dynamics (ECFD 7)

Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus

Autores: Eliasy, A., Chen, K. J., Vinciguerra, R., & Elsheikh, A.
Publicado en: 2018
Editor: 8th World Congress of Biomechanics

Microscopic organization of corneal collagen: Comparison between keratoconic and normal human corneas

Autores: J. Germann, E. Martinez-Enriquez, S. Bueno, A. Mohamed, S. Nandyala, S. Chaurasia, S. Marcos
Publicado en: Investigative Ophthalmology & Visual Science, 2020
Editor: ARVO

Probing temporal structural changes within cornea using 200 kHz swept source nano sensitive optical coherence tomography (nsOCT)

Autores: Cerine Lal, Sergey Alexandrov, Sweta Rani, Thomas Ritter, Martin Leahy
Publicado en: Dynamics and Fluctuations in Biomedical Photonics XVII, 2020, Página(s) 7, ISBN 9781510632424
Editor: SPIE
DOI: 10.1117/12.2553024

Customized swept-source optical coherence tomography system for air-puff induced corneal deformation imaging on multiple meridians (Conference Presentation)

Autores: Andrea Curatolo, Judith Birkenfeld, Eduardo Martínez, James A. Germann, Jesús Palací, Daniel Pascual, Geethika Muralidharan, Jedrzej Solarski, Karol Karnowski, Maciej Wojtkowski, Susana Marcos
Publicado en: Ophthalmic Technologies XXX, 2020, Página(s) 30, ISBN 9781510632004
Editor: SPIE
DOI: 10.1117/12.2546050

Detecting deformation asymmetries on multiple meridians in an ex vivo keratoconic eye model

Autores: Andrea Curatolo; Judith Sophie Birkenfeld; Eduardo Martinez-Enriquez; James Germann; Jesus Palaci; Daniel Pascual; Geethika Muralidharan; Ashkan Eliasy; Ahmed Abass; Jedrzej Solarski; Karol Karnowski; Maciej Wojtkowski; Ahmed Elsheikh; Susana Marcos
Publicado en: Investigative Ophthalmology & Visual Science, 2020
Editor: ARVO

Künstliche Intelligenz zur Entwicklung von Screening-Parametern im Bereich der kornealen Biomechanik

Autores: Sven Reisdorf
Publicado en: Klinische Monatsblätter für Augenheilkunde, Edición 236/12, 2019, Página(s) 1423-1427, ISSN 0023-2165
Editor: Georg Thieme Verlag
DOI: 10.1055/a-1032-8559

Biomechanics of the Eye _ Chapter 6. Material properties of the human cornea: anisotropy

Autores: Eliasy, A., Zhou, D., Studer, H., Boote, C., & Elsheikh, A.
Publicado en: Material properties of the human cornea: anisotropy, 2018
Editor: Kugler Publications

Derechos de propiedad intelectual

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Número de solicitud/publicación: 20 382178
Fecha: 2020-03-11

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Número de solicitud/publicación: 20 382178
Fecha: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Número de solicitud/publicación: 20 382178
Fecha: 2018-04-30

SYSTEM AND METHOD FOR OBTAINING OCULAR TISSUE BIOMECHANICAL PARAMETERS

Número de solicitud/publicación: 20 382178
Fecha: 2018-04-30

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Número de solicitud/publicación: 20 382067
Fecha: 2020-02-02

METHOD AND SYSTEM FOR SCREENING OCULAR TISSUE ABNORMALITY THROUGH DEFORMATION OF THE OCULAR TISSUE

Número de solicitud/publicación: 20 382178
Fecha: 2020-03-11

SYSTEM AND METHOD FOR OBTAINING BIOMECHANICAL PARAMETERS OF OCULAR TISSUE THROUGH DEFORMATION OF THE OCULAR TISSUE

Número de solicitud/publicación: 20 382067
Fecha: 2020-02-02
Solicitante(s): INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK