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An innovative bio-based platform for the cost-competitive production of L-fucose, a building block for Human Milk Oligosaccharides (HMOs).

Project description

Safe and efficient biotechnology delivers the rare precursor to human oligosaccharides

Human milk oligosaccharides (HMOs) are the third most abundant component of human milk after lactose and lipids. They benefit breastfed infants by preventing infection, maintaining immune homeostasis and supporting a healthy gut microbiota. Interest in HMOs is increasing, not only as a supplement to infant formula but also in other nutritional and biomedical applications. However, their production requires L-fucose, a rare monosaccharide with limited natural availability. The EU funded FucoPol project will enable the Portuguese SME 73100 to validate their platform for large scale production of high-purity, high-quality FucoPol. This novel, patented, bacterially fermented biopolymer is a natural source supporting production of pure L-fucose.

Objective

73100 have developed and patented a novel bacterial fermented biopolymer – FucoPol – as a natural source for the efficient production of pure L-fucose. L-fucose is a rare monosaccharide with limited natural availability and a precursor of complex carbohydrates, as Human Milk Oligosaccharides (HMOs). HMOs, which are highly abundant in human milk but not in infant formula, have been recently recognised as natural molecules with high potential for nutritional and biomedical applications. Despite the increasing market demand of these “specialty carbohydrates”, large scale production of HMOs is currently not feasible. Current technologies are hindered by the complexity and costs related to the attempt to increase the availability of the core component L-fucose. In fact, this monosaccharide acts as building block for HMOs, representing over 60-70% of the oligosaccharides portion in human milk. FucoPol – as natural source of pure monosaccharides - solves the main industrial issues related to L-fucose production such as the complexity, costs and efficiency. FucoPol bio-based platform offers a sustainable solution for industrial-commercialization of HMOs, by significantly increasing L-fucose availability. Completing the innovation project objectives will result in the validation of the platform and enable the production of large amount of high-pure L-fucose to meet the quality/quantity industrial demand for this rare sugar.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

SME-2 - SME instrument phase 2

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-SMEInst-2016-2017

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Coordinator

SETENTA E TRES MIL E CEM LDA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 317 195,25
Address
ESTRADA MUNICIPAL 528, N 1, ARRAIOLOS
7040-220 IGREJINHA EVORA
Portugal

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Alentejo Alentejo Central
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 881 707,50
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