The PIDDosome in Centrosome and Ploidy-Surveillance

Project Information

POLICE

Grant agreement ID: 787171

DOI

10.3030/787171

Project closed

EC signature date 19 June 2018

Start date 1 October 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 355 000,00

EU contribution

€ 2 355 000,00

Coordinated by

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Author(s): Ju Youn Kim, Lily Q. Wang, Valentina C. Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D. Jacotot, Ronald M. Evans, Andreas Villunger, Michael Karin
Published in: Cell Metabolism, Issue 34, 2024, Page(s) 1548-1560.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.08.005

Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

Author(s): Matteo Burigotto, Alessia Mattivi, Daniele Migliorati, Giovanni Magnani, Chiara Valentini, Michela Roccuzzo, Martin Offterdinger, Massimo Pizzato, Alexander Schmidt, Andreas Villunger, Stefano Maffini, Luca L Fava
Published in: The EMBO Journal, Issue 40/4, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020104844

Extra centrosomes induce <scp>PIDD1</scp>‐mediated inflammation and immunosurveillance

Author(s): Irmina Garcia‐Carpio, Vincent Z Braun, Elias S Weiler, Marina Leone, Sergio Niñerola, Angel Barco, Luca L Fava, Andreas Villunger
Published in: The EMBO Journal, Issue 42, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2023113510

Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity

Author(s): Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53222-4

PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis

Author(s): Valentina C Sladky, Katja Knapp, Tamas G Szabo, Vincent Z Braun, Laura Bongiovanni, Hilda Bos, Diana CJ Spierings, Bart Westendorp, Ana Curinha, Tatjana Stojakovic, Hubert Scharnagl, Gerald Timelthaler, Kaoru Tsuchia, Matthias Pinter, Georg Semmler, Floris Foijer, Alain Bruin, Thomas Reiberger, Nataliya Rohr‐Udilova, Andreas Villunger
Published in: EMBO reports, Issue 21/12, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050893

Cellular polyploidy in organ homeostasis and regeneration

Author(s): Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter
Published in: Protein &amp; Cell, 2023, ISSN 1674-800X
Publisher: Springer Verlag
DOI: 10.1093/procel/pwac064

At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity

Author(s): Dario Rizzotto, Lukas Englmaier, Andreas Villunger
Published in: International Journal of Molecular Sciences, Issue 22, 2024, Page(s) 10883, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221910883

Amplified centrosomes—more than just a threat

Author(s): Eva Kiermaier, Isabel Stötzel, Marina A Schapfl, Andreas Villunger
Published in: EMBO Reports, Issue 25, 2024, Page(s) 4153-4167, ISSN 1469-3178
Publisher: NPG
DOI: 10.1038/s44319-024-00260-0

PIDD1 in cell cycle control, sterile inflammation and cell death

Author(s): Elias S. Weiler, Tamas G. Szabo, Irmina Garcia-Carpio, Andreas Villunger
Published in: Biochemical Society Transactions, Issue 50, 2022, Page(s) 813-824, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20211186

Extra centrosomes delay DNA damage–driven tumorigenesis

Author(s): Vincent Z. Braun, Gerlinde Karbon, Fabian Schuler, Marina A. Schapfl, Johannes G. Weiss, Paul Y. Petermann, Diana C.J. Spierings, Andrea E. Tijhuis, Floris Foijer, Verena Labi, Andreas Villunger
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.adk0564

The <scp>SKP2</scp>‐p27 axis defines susceptibility to cell death upon <scp>CHK1</scp> inhibition

Author(s): Michael Lohmüller, Bernhard F. Roeck, Tamas G. Szabo, Marina A. Schapfl, Fragka Pegka, Sebastian Herzog, Andreas Villunger, Fabian Schuler
Published in: Molecular Oncology, Issue 16, 2023, Page(s) 2771-2787, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.13264

Caspase-2 kills cells with extra centrosomes

Author(s): Dario Rizzotto, Vincenza Vigorito, Patricia Rieder, Filip Gallob, Gian Mario Moretta, Claudia Soratroi, Joel S. Riley, Florian Bellutti, Stefano Li Veli, Alessia Mattivi, Michael Lohmüller, Sebastian Herzog, Beat C. Bornhauser, Etienne D. Jacotot, Andreas Villunger, Luca L. Fava
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.ado6607

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

Author(s): Valentina C. Sladky, Katja Knapp, Claudia Soratroi, Julia Heppke, Felix Eichin, Lourdes Rocamora-Reverte, Tamas G. Szabo, Laura Bongiovanni, Bart Westendorp, Eva Moreno, Elsbeth A. van Liere, Bjorn Bakker, Diana C.J. Spierings, René Wardenaar, David Pereyra, Patrick Starlinger, Simon Schultze, Michael Trauner, Tatjana Stojakovic, Hubert Scharnagl, Luca L. Fava, Floris Foijer, Alain de Bruin, Andr
Published in: Developmental Cell, Issue 52/3, 2020, Page(s) 335-349.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.12.016

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation

Author(s): Valentina C. Sladky, Andreas Villunger
Published in: Cell Death & Differentiation, Issue 12/12, 2020, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-020-0556-6

Cell-Cycle Cross Talk with Caspases and Their Substrates

Author(s): Patrick Connolly, Irmina Garcia-Carpio, Andreas Villunger
Published in: Cold Spring Harbor Perspectives in Biology, Issue 12/6, 2020, Page(s) a036475, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a036475

Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

Author(s): Taimoor I. Sheikh, Nasim Vasli, Stephen Pastore, Kimia Kharizi, Ricardo Harripaul, Zohreh Fattahi, Shruti Pande, Farooq Naeem, Abrar Hussain, Asif Mir, Omar Islam, Katta Mohan Girisha, Muhammad Irfan, Muhammad Ayub, Christoph Schwarzer, Hossein Najmabadi, Anju Shukla, Valentina C. Sladky, Vincent Zoran Braun, Irmina Garcia-Carpio, Andreas Villunger, John B. Vincent
Published in: Translational Psychiatry, Issue 11/1, 2021, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-01158-w

Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy

Author(s): Gerlinde Karbon, Fabian Schuler, Vincent Z Braun, Felix Eichin, Manuel Haschka, Mathias Drach, Rocio Sotillo, Stephan Geley, Diana CJ Spierings, Andrea E Tijhuis, Floris Foijer, Andreas Villunger
Published in: EMBO Reports, Issue 25, 2024, Page(s) 2743-2772, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.1038/s44319-024-00160-3

Apoptosis as a Barrier against CIN and Aneuploidy

Author(s): Johannes Weiss, Filip Gallob, Patricia Rieder, Andreas Villunger
Published in: Cancers, Issue 15, 2023, Page(s) 30, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010030