The PIDDosome in Centrosome and Ploidy-Surveillance

Project Information

POLICE

Grant agreement ID: 787171

DOI 10.3030/787171

EC signature date 19 June 2018

Start date 1 October 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 355 000,00

EU contribution € 2 355 000,00

Coordinated by

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

Publications

Peer reviewed articles (6)

Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

Author(s): Matteo Burigotto, Alessia Mattivi, Daniele Migliorati, Giovanni Magnani, Chiara Valentini, Michela Roccuzzo, Martin Offterdinger, Massimo Pizzato, Alexander Schmidt, Andreas Villunger, Stefano Maffini, Luca L Fava
Published in: The EMBO Journal, Issue 40/4, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020104844

PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis

Author(s): Valentina C Sladky, Katja Knapp, Tamas G Szabo, Vincent Z Braun, Laura Bongiovanni, Hilda Bos, Diana CJ Spierings, Bart Westendorp, Ana Curinha, Tatjana Stojakovic, Hubert Scharnagl, Gerald Timelthaler, Kaoru Tsuchia, Matthias Pinter, Georg Semmler, Floris Foijer, Alain Bruin, Thomas Reiberger, Nataliya Rohr‐Udilova, Andreas Villunger
Published in: EMBO reports, Issue 21/12, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050893

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

Author(s): Valentina C. Sladky, Katja Knapp, Claudia Soratroi, Julia Heppke, Felix Eichin, Lourdes Rocamora-Reverte, Tamas G. Szabo, Laura Bongiovanni, Bart Westendorp, Eva Moreno, Elsbeth A. van Liere, Bjorn Bakker, Diana C.J. Spierings, René Wardenaar, David Pereyra, Patrick Starlinger, Simon Schultze, Michael Trauner, Tatjana Stojakovic, Hubert Scharnagl, Luca L. Fava, Floris Foijer, Alain de Bruin, Andr
Published in: Developmental Cell, Issue 52/3, 2020, Page(s) 335-349.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.12.016

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation

Author(s): Valentina C. Sladky, Andreas Villunger
Published in: Cell Death & Differentiation, Issue 12/12, 2020, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-020-0556-6

Cell-Cycle Cross Talk with Caspases and Their Substrates

Author(s): Patrick Connolly, Irmina Garcia-Carpio, Andreas Villunger
Published in: Cold Spring Harbor Perspectives in Biology, Issue 12/6, 2020, Page(s) a036475, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a036475

Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

Author(s): Taimoor I. Sheikh, Nasim Vasli, Stephen Pastore, Kimia Kharizi, Ricardo Harripaul, Zohreh Fattahi, Shruti Pande, Farooq Naeem, Abrar Hussain, Asif Mir, Omar Islam, Katta Mohan Girisha, Muhammad Irfan, Muhammad Ayub, Christoph Schwarzer, Hossein Najmabadi, Anju Shukla, Valentina C. Sladky, Vincent Zoran Braun, Irmina Garcia-Carpio, Andreas Villunger, John B. Vincent
Published in: Translational Psychiatry, Issue 11/1, 2021, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-01158-w