Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors

Project Information

SelectiveTGFb-inhib

Grant agreement ID: 787472

DOI

10.3030/787472

Project closed

EC signature date 20 June 2018

Start date 1 November 2018

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Author(s): Noopur Thakur, Anahita Hamidi, Jie Song, Susumu Itoh, Anders Bergh, Carl-Henrik Heldin, Maréne Landström
Published in: iScience, Issue 23/9, 2020, Page(s) 101470, ISSN 2589-0042
Publisher: CellPress
DOI: 10.1016/j.isci.2020.101470

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A

Author(s): Ryo Tanabe; Kohei Miyazono; Tomoki Todo; Nobuhito Saito; Caname Iwata; Akiyoshi Komuro; Satoshi Sakai; Erna Raja; Daizo Koinuma; Masato Morikawa; Bengt Westermark; Carl‐Henrik Heldin
Published in: Molecular Oncology, Issue 16, 2021, Page(s) 269-288, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.13051

The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma

Author(s): Laia Caja; Mahsa Shahidi Dadras; Artur Mezheyeuski; Dorival Mendes Rodrigues‐Junior; Sijia Liu; Anna Taylor Webb; Maria Catalina Gomez‐Puerto; Peter ten Dijke; Carl‐Henrik Heldin; Aristidis Moustakas
Published in: Journal of Cellular Physiology, 2021, ISSN 1097-4652
Publisher: Wiley
DOI: 10.1002/jcp.30542

TGFb selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Author(s): Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin and Aristidis Moustakas
Published in: Molecular Oncology, Issue 16, 2022, Page(s) 2330-2354, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.13215

The ubiquitin-ligase TRAF6 and TGFb type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Author(s): Jie Song, Yang Zhou, Ihor Yakymovych, Alexej Schmidt Chunjan Li, Carl-Henrik Heldin and Marene Landström
Published in: eBioMedicine, Issue 82, 2022, Page(s) 104155, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104155

BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Author(s): Tomohiko Fukuda; Risa Fukuda; Daizo Koinuma; Aristidis Moustakas; Kohei Miyazono; Carl-Henrik Heldin
Published in: Cellular Signaling, Issue 87, 2021, Page(s) 110146, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110146

The long non-coding RNA LIN00707 interacts with Smad proteins to regulate TGFb signaling and cancer cell invasion

Author(s): Caroline Gélabert, Panagiotis Papousoglou, Irene Golán, Eric Ahlström, Adam Ameur, Carl-Henrik Heldin, Laia Caja, Aristidis Moustakas
Published in: Cell Communication and Signaling, Issue 21, 2023, Page(s) 271, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-023-01273-3

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Author(s): Chrysoula Tsirigoti, Mohamad Moustafa Ali, Varun Maturi, Carl-Henrik Heldin and Aristidis Moustakas
Published in: Cell Death and Disease, Issue 13, 2022, Page(s) 832, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-05280-z

BMP signaling is a therapeutic target in ovarian cancer

Author(s): Tomohiko Fukuda, Risa Fukuda, Ryo Tanabe, Daizo Koinuma, Hiroo Koyama, Yoshinobu Hashizume, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin
Published in: Cell Death Discovery, Issue 6/1, 2020, ISSN 2058-7716
Publisher: SpringerNature CDDpress
DOI: 10.1038/s41420-020-00377-w

The liver kinase B1 supports Mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Author(s): Kalliopi Tzavlaki, Yae Ohata, Anita Morén, Yukihide Watanabe, Jens Eriksson, Naiko Tsuchiya, Yuki Kobo, Kouhei Yamamoto, Mikael E Sellin, Mitsuyasu Kato, Laia Caja, Carl-Henrik Heldin and Aristidis Moustakas
Published in: Journal of Cellular Physiology, Issue 238, 2023, Page(s) 790-812, ISSN 0021-9541
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30975

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Author(s): Tomohiko Fukuda; Risa Fukuda; Kohei Miyazono; Carl-Henrik Heldin
Published in: International Journal of Molecular Sciences, Issue 22, 2021, Page(s) 7882, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22157882

The type II TGF-b receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling

Author(s): Ihor Yakymovych, Mariya Yakymovych, Anahita Hamidi, Maréne Landström and Carl-Henrik Heldin
Published in: Science Signaling, Issue 15, 2022, Page(s) eabp9521, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abp9521

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Author(s): Constantinos Kolliopoulos, Erna Raja, Masoud Razmara, Paraskevi Heldin, Carl-Henrik Heldin, Aristidis Moustakas, Lars P. van der Heide
Published in: Journal of Biological Chemistry, Issue 294/11, 2019, Page(s) 4119-4136, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004984

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation

Author(s): Anita Morén, Claudia Bellomo, Yutaro Tsubakihara, Dimitris Kardassis, Wolfgang Mikulits, Carl-Henrik Heldin, Aristidis Moustakas
Published in: Oncogenesis, Issue 8/6, 2019, ISSN 2157-9024
Publisher: Nature Publishing Group
DOI: 10.1038/s41389-019-0140-4

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Author(s): Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma-van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Published in: Cells, Issue 8/12, 2019, Page(s) 1481, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8121481

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Author(s): Masato Morikawa, Yoshihide Mitani, Katarina Holmborn, Taichi Kato, Daizo Koinuma, Junko Maruyama, Eleftheria Vasilaki, Hirofumi Sawada, Mai Kobayashi, Takayuki Ozawa, Yasuyuki Morishita, Yasumasa Bessho, Shingo Maeda, Johan Ledin, Hiroyuki Aburatani, Ryoichiro Kageyama, Kazuo Maruyama, Carl-Henrik Heldin, Kohei Miyazono
Published in: Science Signaling, Issue 12/607, 2019, Page(s) eaay4430, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aay4430

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

Author(s): Panagiotis Papoutsoglou, Yutaro Tsubakihara, Laia Caja, Anita Morén, Paris Pallis, Adam Ameur, Carl-Henrik Heldin, Aristidis Moustakas
Published in: Cell Reports, Issue 28/12, 2019, Page(s) 3182-3198.e11, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.08.028

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness

Author(s): Anders Sundqvist, Eleftheria Vasilaki, Oleksandr Voytyuk, Yu Bai, Masato Morikawa, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Published in: Oncogene, 2020, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-020-1299-z

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling

Author(s): Panagiotis Papoutsoglou, Dorival Mendes Rodrigues-Junior, Anita Morén, Andrew Bergman, Fredrik Pontén, Cédric Coulouarn, Laia Caja, Carl-Henrik Heldin, Aristidis Moustakas
Published in: Oncogene, Issue 40/21, 2021, Page(s) 3748-3765, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-021-01803-8

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Author(s): Mahsa Shahidi Dadras, Laia Caja, Artur Mezheyeuski, Sijia Liu, Caroline Gélabert, Maria Catalina Gomez-Puerto, Radiosa Gallini, Carl-Johan Rubin, Peter ten Dijke, Carl-Henrik Heldin and Aristidis Moustakas
Published in: Cell Death and Disease, Issue 12, 2021, Page(s) 932, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-04220-7