Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors

Informazioni relative al progetto

SelectiveTGFb-inhib

ID dell’accordo di sovvenzione: 787472

DOI

10.3030/787472

Progetto chiuso

Data della firma CE 20 Giugno 2018

Data di avvio 1 Novembre 2018

Data di completamento 31 Ottobre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

UPPSALA UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (20)

Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Autori: Noopur Thakur, Anahita Hamidi, Jie Song, Susumu Itoh, Anders Bergh, Carl-Henrik Heldin, Maréne Landström
Pubblicato in: iScience, Numero 23/9, 2020, Pagina/e 101470, ISSN 2589-0042
Editore: CellPress
DOI: 10.1016/j.isci.2020.101470

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A

Autori: Ryo Tanabe; Kohei Miyazono; Tomoki Todo; Nobuhito Saito; Caname Iwata; Akiyoshi Komuro; Satoshi Sakai; Erna Raja; Daizo Koinuma; Masato Morikawa; Bengt Westermark; Carl‐Henrik Heldin
Pubblicato in: Molecular Oncology, Numero 16, 2021, Pagina/e 269-288, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.13051

The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma

Autori: Laia Caja; Mahsa Shahidi Dadras; Artur Mezheyeuski; Dorival Mendes Rodrigues‐Junior; Sijia Liu; Anna Taylor Webb; Maria Catalina Gomez‐Puerto; Peter ten Dijke; Carl‐Henrik Heldin; Aristidis Moustakas
Pubblicato in: Journal of Cellular Physiology, 2021, ISSN 1097-4652
Editore: Wiley
DOI: 10.1002/jcp.30542

TGFb selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Autori: Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin and Aristidis Moustakas
Pubblicato in: Molecular Oncology, Numero 16, 2022, Pagina/e 2330-2354, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.13215

The ubiquitin-ligase TRAF6 and TGFb type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Autori: Jie Song, Yang Zhou, Ihor Yakymovych, Alexej Schmidt Chunjan Li, Carl-Henrik Heldin and Marene Landström
Pubblicato in: eBioMedicine, Numero 82, 2022, Pagina/e 104155, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104155

BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Autori: Tomohiko Fukuda; Risa Fukuda; Daizo Koinuma; Aristidis Moustakas; Kohei Miyazono; Carl-Henrik Heldin
Pubblicato in: Cellular Signaling, Numero 87, 2021, Pagina/e 110146, ISSN 0898-6568
Editore: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110146

The long non-coding RNA LIN00707 interacts with Smad proteins to regulate TGFb signaling and cancer cell invasion

Autori: Caroline Gélabert, Panagiotis Papousoglou, Irene Golán, Eric Ahlström, Adam Ameur, Carl-Henrik Heldin, Laia Caja, Aristidis Moustakas
Pubblicato in: Cell Communication and Signaling, Numero 21, 2023, Pagina/e 271, ISSN 1478-811X
Editore: BioMed Central
DOI: 10.1186/s12964-023-01273-3

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Autori: Chrysoula Tsirigoti, Mohamad Moustafa Ali, Varun Maturi, Carl-Henrik Heldin and Aristidis Moustakas
Pubblicato in: Cell Death and Disease, Numero 13, 2022, Pagina/e 832, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-05280-z

BMP signaling is a therapeutic target in ovarian cancer

Autori: Tomohiko Fukuda, Risa Fukuda, Ryo Tanabe, Daizo Koinuma, Hiroo Koyama, Yoshinobu Hashizume, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin
Pubblicato in: Cell Death Discovery, Numero 6/1, 2020, ISSN 2058-7716
Editore: SpringerNature CDDpress
DOI: 10.1038/s41420-020-00377-w

The liver kinase B1 supports Mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Autori: Kalliopi Tzavlaki, Yae Ohata, Anita Morén, Yukihide Watanabe, Jens Eriksson, Naiko Tsuchiya, Yuki Kobo, Kouhei Yamamoto, Mikael E Sellin, Mitsuyasu Kato, Laia Caja, Carl-Henrik Heldin and Aristidis Moustakas
Pubblicato in: Journal of Cellular Physiology, Numero 238, 2023, Pagina/e 790-812, ISSN 0021-9541
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30975

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Autori: Tomohiko Fukuda; Risa Fukuda; Kohei Miyazono; Carl-Henrik Heldin
Pubblicato in: International Journal of Molecular Sciences, Numero 22, 2021, Pagina/e 7882, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22157882

The type II TGF-b receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling

Autori: Ihor Yakymovych, Mariya Yakymovych, Anahita Hamidi, Maréne Landström and Carl-Henrik Heldin
Pubblicato in: Science Signaling, Numero 15, 2022, Pagina/e eabp9521, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abp9521

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Autori: Constantinos Kolliopoulos, Erna Raja, Masoud Razmara, Paraskevi Heldin, Carl-Henrik Heldin, Aristidis Moustakas, Lars P. van der Heide
Pubblicato in: Journal of Biological Chemistry, Numero 294/11, 2019, Pagina/e 4119-4136, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004984

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation

Autori: Anita Morén, Claudia Bellomo, Yutaro Tsubakihara, Dimitris Kardassis, Wolfgang Mikulits, Carl-Henrik Heldin, Aristidis Moustakas
Pubblicato in: Oncogenesis, Numero 8/6, 2019, ISSN 2157-9024
Editore: Nature Publishing Group
DOI: 10.1038/s41389-019-0140-4

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Autori: Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma-van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Pubblicato in: Cells, Numero 8/12, 2019, Pagina/e 1481, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells8121481

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Autori: Masato Morikawa, Yoshihide Mitani, Katarina Holmborn, Taichi Kato, Daizo Koinuma, Junko Maruyama, Eleftheria Vasilaki, Hirofumi Sawada, Mai Kobayashi, Takayuki Ozawa, Yasuyuki Morishita, Yasumasa Bessho, Shingo Maeda, Johan Ledin, Hiroyuki Aburatani, Ryoichiro Kageyama, Kazuo Maruyama, Carl-Henrik Heldin, Kohei Miyazono
Pubblicato in: Science Signaling, Numero 12/607, 2019, Pagina/e eaay4430, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aay4430

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

Autori: Panagiotis Papoutsoglou, Yutaro Tsubakihara, Laia Caja, Anita Morén, Paris Pallis, Adam Ameur, Carl-Henrik Heldin, Aristidis Moustakas
Pubblicato in: Cell Reports, Numero 28/12, 2019, Pagina/e 3182-3198.e11, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.08.028

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness

Autori: Anders Sundqvist, Eleftheria Vasilaki, Oleksandr Voytyuk, Yu Bai, Masato Morikawa, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Pubblicato in: Oncogene, 2020, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-020-1299-z

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling

Autori: Panagiotis Papoutsoglou, Dorival Mendes Rodrigues-Junior, Anita Morén, Andrew Bergman, Fredrik Pontén, Cédric Coulouarn, Laia Caja, Carl-Henrik Heldin, Aristidis Moustakas
Pubblicato in: Oncogene, Numero 40/21, 2021, Pagina/e 3748-3765, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-021-01803-8

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Autori: Mahsa Shahidi Dadras, Laia Caja, Artur Mezheyeuski, Sijia Liu, Caroline Gélabert, Maria Catalina Gomez-Puerto, Radiosa Gallini, Carl-Johan Rubin, Peter ten Dijke, Carl-Henrik Heldin and Aristidis Moustakas
Pubblicato in: Cell Death and Disease, Numero 12, 2021, Pagina/e 932, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-04220-7