Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors

Información del proyecto

SelectiveTGFb-inhib

Identificador del acuerdo de subvención: 787472

DOI

10.3030/787472

Proyecto cerrado

Fecha de la firma de la CE 20 Junio 2018

Fecha de inicio 1 Noviembre 2018

Fecha de finalización 31 Octubre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UPPSALA UNIVERSITET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Autores: Noopur Thakur, Anahita Hamidi, Jie Song, Susumu Itoh, Anders Bergh, Carl-Henrik Heldin, Maréne Landström
Publicado en: iScience, Edición 23/9, 2020, Página(s) 101470, ISSN 2589-0042
Editor: CellPress
DOI: 10.1016/j.isci.2020.101470

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A

Autores: Ryo Tanabe; Kohei Miyazono; Tomoki Todo; Nobuhito Saito; Caname Iwata; Akiyoshi Komuro; Satoshi Sakai; Erna Raja; Daizo Koinuma; Masato Morikawa; Bengt Westermark; Carl‐Henrik Heldin
Publicado en: Molecular Oncology, Edición 16, 2021, Página(s) 269-288, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13051

The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma

Autores: Laia Caja; Mahsa Shahidi Dadras; Artur Mezheyeuski; Dorival Mendes Rodrigues‐Junior; Sijia Liu; Anna Taylor Webb; Maria Catalina Gomez‐Puerto; Peter ten Dijke; Carl‐Henrik Heldin; Aristidis Moustakas
Publicado en: Journal of Cellular Physiology, 2021, ISSN 1097-4652
Editor: Wiley
DOI: 10.1002/jcp.30542

TGFb selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Autores: Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin and Aristidis Moustakas
Publicado en: Molecular Oncology, Edición 16, 2022, Página(s) 2330-2354, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13215

The ubiquitin-ligase TRAF6 and TGFb type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Autores: Jie Song, Yang Zhou, Ihor Yakymovych, Alexej Schmidt Chunjan Li, Carl-Henrik Heldin and Marene Landström
Publicado en: eBioMedicine, Edición 82, 2022, Página(s) 104155, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104155

BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Autores: Tomohiko Fukuda; Risa Fukuda; Daizo Koinuma; Aristidis Moustakas; Kohei Miyazono; Carl-Henrik Heldin
Publicado en: Cellular Signaling, Edición 87, 2021, Página(s) 110146, ISSN 0898-6568
Editor: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110146

The long non-coding RNA LIN00707 interacts with Smad proteins to regulate TGFb signaling and cancer cell invasion

Autores: Caroline Gélabert, Panagiotis Papousoglou, Irene Golán, Eric Ahlström, Adam Ameur, Carl-Henrik Heldin, Laia Caja, Aristidis Moustakas
Publicado en: Cell Communication and Signaling, Edición 21, 2023, Página(s) 271, ISSN 1478-811X
Editor: BioMed Central
DOI: 10.1186/s12964-023-01273-3

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Autores: Chrysoula Tsirigoti, Mohamad Moustafa Ali, Varun Maturi, Carl-Henrik Heldin and Aristidis Moustakas
Publicado en: Cell Death and Disease, Edición 13, 2022, Página(s) 832, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-022-05280-z

BMP signaling is a therapeutic target in ovarian cancer

Autores: Tomohiko Fukuda, Risa Fukuda, Ryo Tanabe, Daizo Koinuma, Hiroo Koyama, Yoshinobu Hashizume, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin
Publicado en: Cell Death Discovery, Edición 6/1, 2020, ISSN 2058-7716
Editor: SpringerNature CDDpress
DOI: 10.1038/s41420-020-00377-w

The liver kinase B1 supports Mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Autores: Kalliopi Tzavlaki, Yae Ohata, Anita Morén, Yukihide Watanabe, Jens Eriksson, Naiko Tsuchiya, Yuki Kobo, Kouhei Yamamoto, Mikael E Sellin, Mitsuyasu Kato, Laia Caja, Carl-Henrik Heldin and Aristidis Moustakas
Publicado en: Journal of Cellular Physiology, Edición 238, 2023, Página(s) 790-812, ISSN 0021-9541
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30975

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Autores: Tomohiko Fukuda; Risa Fukuda; Kohei Miyazono; Carl-Henrik Heldin
Publicado en: International Journal of Molecular Sciences, Edición 22, 2021, Página(s) 7882, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22157882

The type II TGF-b receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling

Autores: Ihor Yakymovych, Mariya Yakymovych, Anahita Hamidi, Maréne Landström and Carl-Henrik Heldin
Publicado en: Science Signaling, Edición 15, 2022, Página(s) eabp9521, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abp9521

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Autores: Constantinos Kolliopoulos, Erna Raja, Masoud Razmara, Paraskevi Heldin, Carl-Henrik Heldin, Aristidis Moustakas, Lars P. van der Heide
Publicado en: Journal of Biological Chemistry, Edición 294/11, 2019, Página(s) 4119-4136, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004984

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation

Autores: Anita Morén, Claudia Bellomo, Yutaro Tsubakihara, Dimitris Kardassis, Wolfgang Mikulits, Carl-Henrik Heldin, Aristidis Moustakas
Publicado en: Oncogenesis, Edición 8/6, 2019, ISSN 2157-9024
Editor: Nature Publishing Group
DOI: 10.1038/s41389-019-0140-4

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Autores: Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma-van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Publicado en: Cells, Edición 8/12, 2019, Página(s) 1481, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8121481

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Autores: Masato Morikawa, Yoshihide Mitani, Katarina Holmborn, Taichi Kato, Daizo Koinuma, Junko Maruyama, Eleftheria Vasilaki, Hirofumi Sawada, Mai Kobayashi, Takayuki Ozawa, Yasuyuki Morishita, Yasumasa Bessho, Shingo Maeda, Johan Ledin, Hiroyuki Aburatani, Ryoichiro Kageyama, Kazuo Maruyama, Carl-Henrik Heldin, Kohei Miyazono
Publicado en: Science Signaling, Edición 12/607, 2019, Página(s) eaay4430, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aay4430

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

Autores: Panagiotis Papoutsoglou, Yutaro Tsubakihara, Laia Caja, Anita Morén, Paris Pallis, Adam Ameur, Carl-Henrik Heldin, Aristidis Moustakas
Publicado en: Cell Reports, Edición 28/12, 2019, Página(s) 3182-3198.e11, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.08.028

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness

Autores: Anders Sundqvist, Eleftheria Vasilaki, Oleksandr Voytyuk, Yu Bai, Masato Morikawa, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Publicado en: Oncogene, 2020, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-020-1299-z

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling

Autores: Panagiotis Papoutsoglou, Dorival Mendes Rodrigues-Junior, Anita Morén, Andrew Bergman, Fredrik Pontén, Cédric Coulouarn, Laia Caja, Carl-Henrik Heldin, Aristidis Moustakas
Publicado en: Oncogene, Edición 40/21, 2021, Página(s) 3748-3765, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-021-01803-8

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Autores: Mahsa Shahidi Dadras, Laia Caja, Artur Mezheyeuski, Sijia Liu, Caroline Gélabert, Maria Catalina Gomez-Puerto, Radiosa Gallini, Carl-Johan Rubin, Peter ten Dijke, Carl-Henrik Heldin and Aristidis Moustakas
Publicado en: Cell Death and Disease, Edición 12, 2021, Página(s) 932, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-04220-7