CTCF control of genome stability in ageing

Project Information

CTCFStableGenome

Grant agreement ID: 788937

DOI

10.3030/788937

Project closed

EC signature date 25 June 2018

Start date 1 September 2019

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 488 251,00

EU contribution

€ 2 488 251,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Author(s): Jasper Panten, Stefania Del Prete, James P. Cleland, Lauren M. Saunders, Job van Riet, Anja Schneider, Paul Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Edith Heard, Duncan T. Odom
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52640-8

DNA lesion bypass and the stochastic dynamics of transcription-coupled repair

Author(s): Michael D. Nicholson, Craig J. Anderson, Duncan T. Odom, Sarah J. Aitken, Martin S. Taylor
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2403871121

Polyploidisation pleiotropically buffers ageing in hepatocytes

Author(s): Kelvin Yin, Maren Büttner, Ioannis K. Deligiannis, Mateusz Strzelecki, Liwei Zhang, Carlos Talavera-López, Fabian Theis, Duncan T. Odom, Celia P. Martinez-Jimenez
Published in: Journal of Hepatology, Issue 81, 2024, Page(s) 289-302, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.03.043

A transcriptional and regulatory map of mouse somite maturation

Author(s): Ximena Ibarra-Soria, Elodie Thierion, Gi Fay Mok, Andrea E. Münsterberg, Duncan T. Odom, John C. Marioni
Published in: Developmental Cell, Issue 58, 2024, Page(s) 1983-1995.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2023.07.003

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Author(s): Jasper Panten, Tobias Heinen, Christina Ernst, Nils Eling, Rebecca E. Wagner, Maja Satorius, John C. Marioni, Oliver Stegle, Duncan T. Odom
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45133-1

Functional signatures of evolutionarily young CTCF binding sites

Author(s): Dhoyazan Azazi, Jonathan M. Mudge, Duncan T. Odom, Paul Flicek
Published in: BMC Biology, Issue 18, 2021, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-020-00863-8

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

Author(s): Paul Adrian Ginno, Helena Borgers, Christina Ernst, Anja Schneider, Mikaela Behm, Sarah J. Aitken, Martin S. Taylor, Duncan T. Odom
Published in: Nature Genetics, Issue 56, 2024, Page(s) 913-924, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-024-01712-y

Universal DNA methylation age across mammalian tissues

Author(s): A. T. Lu, Z. Fei, A. Haghani, T. R. Robeck, J. A. Zoller, C. Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V. A. Acosta-Rodriguez, D. M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C. S. Baker, G. Banks, K. Belov, N. C. Bennett, P. Black, D. T. Blumstein, E. K. Bors, C. E. Breeze, R. T. Brooke, J. L. Brown, G. G. Carter, A. Caulton, J. M. Cavin, L. Chakrabarti, I. Chatzistamou,
Published in: Nature Aging, Issue 3, 2023, Page(s) 1144-1166, ISSN 2662-8465
Publisher: NPG
DOI: 10.1038/s43587-023-00462-6

Pervasive lesion segregation shapes cancer genome evolution

Author(s): Sarah J. Aitken, Craig J. Anderson, Frances Connor, Oriol Pich, Vasavi Sundaram, Christine Feig, Tim F. Rayner, Margus Lukk, Stuart Aitken, Juliet Luft, Elissavet Kentepozidou, Claudia Arnedo-Pac, Sjoerd V. Beentjes, Susan E. Davies, Ruben M. Drews, Ailith Ewing, Vera B. Kaiser, Ava Khamseh, Erika López-Arribillaga, Aisling M. Redmond, Javier Santoyo-Lopez, Inés Sentís, Lana Talmane, Andrew D.
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2435-1

Strand-resolved mutagenicity of DNA damage and repair

Author(s): Craig J. Anderson, Lana Talmane, Juliet Luft, John Connelly, Michael D. Nicholson, Jan C. Verburg, Oriol Pich, Susan Campbell, Marco Giaisi, Pei-Chi Wei, Vasavi Sundaram, Frances Connor, Paul A. Ginno, Takayo Sasaki, David M. Gilbert, null null, Stuart Aitken, Claudia Arnedo-Pac, Maëlle Daunesse, Ruben M. Drews, Ailith Ewing, Christine Feig, Paul Flicek, Vera B. Kaiser, Elissavet Kentepozidou, Er
Published in: Nature, Issue 630, 2024, Page(s) 744-751, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07490-1

LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions.

Author(s): Maša Roller; Ericca Stamper; Ericca Stamper; Ericca Stamper; Diego Villar; Diego Villar; Osagie G. Izuogu; Fergal J. Martin; Aisling M. Redmond; Raghavendra Ramachanderan; Louise Harewood; Louise Harewood; Duncan T. Odom; Duncan T. Odom; Paul Flicek; Paul Flicek; Paul Flicek
Published in: Genome Biology, Issue 3, 2020, ISSN 1474-760X
Publisher: BioMedCentral
DOI: 10.1186/s13059-021-02260-y

DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts

Author(s): Martina Rimoldi, Ning Wang, Jilin Zhang, Diego Villar, Duncan T. Odom, Jussi Taipale, Paul Flicek, Maša Roller
Published in: Genome Biology, 2022, ISSN 1474-760X
Publisher: Pubmedcentral
DOI: 10.1101/2022.07.21.500978