Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics

Project Information

CODE

Grant agreement ID: 788954

DOI 10.3030/788954

EC signature date 31 May 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

Objective

Specific recruitment of different proteins to distinct intracellular membranes is fundamental in the biology of eukaryotic cells, but the molecular basis for specificity is incompletely understood. This proposal investigates the hypothesis that coincidence detection of proteins and lipids constitutes a major mechanism for specific recruitment of proteins to intracellular membranes in order to control cellular membrane dynamics. CODE will establish and validate mathematical models for coincidence detection, identify and functionally characterise novel coincidence detectors, and engineer artificial coincidence detectors as novel tools in cell biology and biotechnology.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › cell biology
• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• natural sciences › mathematics › applied mathematics › mathematical model

Keywords

• Membrane traffic
• Endocytosis
• Phosphoinositides

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2017-ADG - ERC Advanced Grant

Call for proposal

ERC-2017-ADG

Funding Scheme

ERC-ADG - Advanced Grant

Host institution

UNIVERSITETET I OSLO

• Net EU contribution: € 1 905 625,00
• Address: PROBLEMVEIEN 5-7 ; 0313 Oslo ; Norway
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 2 500 000,00

Beneficiaries (2)

UNIVERSITETET I OSLO

Norway

• Net EU contribution: € 1 905 625,00
• Address: PROBLEMVEIEN 5-7 ; 0313 Oslo
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 2 500 000,00

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSLO UNIVERSITETSSYKEHUS HF

Norway

• Net EU contribution: € 594 375,00
• Address: KIRKEVEIEN 166 TARNBYGGET ; 0450 Oslo
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data