Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics

Project Information

CODE

Grant agreement ID: 788954

DOI

10.3030/788954

Project closed

EC signature date 31 May 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (38)

Lysophagy prevents neurotoxic aggregate transmission

Author(s): Maja Radulovic, Harald Stenmark
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2321181121

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

Author(s): Maja Radulovic, Eva Maria Wenzel, Sania Gilani, Lya KK Holland, Alf Håkon Lystad, Santosh Phuyal, Vesa M. Olkkonen, Andreas Brech, Marja Jäättelä, Kenji Maeda, Camilla Raiborg, Harald Stenmark
Published in: EMBO Journal, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022112677

<scp>TECPR1</scp> is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

Author(s): Namrita Kaur, Laura Rodriguez de la Ballina, Håvard Styrkestad Haukaas, Maria Lyngaas Torgersen, Maja Radulovic, Michael J Munson, Alan Sabirsh, Harald Stenmark, Anne Simonsen, Sven R Carlsson, Alf Håkon Lystad
Published in: The EMBO Journal, Issue 42, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022113105

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Author(s): Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.51063

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Author(s): Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45558-8

ESCRTed resistance to T cell attack

Author(s): Simona Maria Migliano, Harald Stenmark
Published in: Trends in Immunology, 2022, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2022.06.007

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

Author(s): Astrid Skjesol, Mariia Yurchenko, Korbinian Bösl, Caroline Gravastrand, Kaja Elisabeth Nilsen, Lene Melsæther Grøvdal, Federica Agliano, Francesco Patane, Germana Lentini, Hera Kim, Giuseppe Teti, Aditya Kumar Sharma, Richard K. Kandasamy, Bjørnar Sporsheim, Kristian K. Starheim, Douglas T. Golenbock, Harald Stenmark, Mary McCaffrey, Terje Espevik, Harald Husebye
Published in: PLOS Pathogens, Issue 15/3, 2019, Page(s) e1007684, ISSN 1553-7374
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1007684

Exosome regulation by Rubicon in ageing

Author(s): Yan Zhen, Harald Stenmark
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 1380-1381, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01482-z

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Author(s): Simona Maria Migliano, Eva Maria Wenzel, Harald Stenmark
Published in: Current Opinion in Cell Biology, 2022, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2022.01.007

Removal of hypersignaling endosomes by simaphagy

Author(s): Simona M. Migliano, Sebastian W. Schultz, Eva M. Wenzel, Szabolcs Takáts, Dan Liu, Silje Mørk, Kia Wee Tan, Tor Erik Rusten, Camilla Raiborg, Harald Stenmark
Published in: Autophagy, Issue 20, 2024, Page(s) 769-791, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2023.2267958

Tumor suppression by control of matrix metalloproteinase recycling

Author(s): Marte Sneeggen, Kay O. Schink, Harald Stenmark
Published in: Molecular & Cellular Oncology, Issue 6/6, 2019, Page(s) e1646606, ISSN 2372-3556
Publisher: Frontiers Media SA
DOI: 10.1080/23723556.2019.1646606

Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles

Author(s): Susanne Liese, Eva Maria Wenzel, Ingrid Kjos, Rossana Rojas Molina, Sebastian W. Schultz, Andreas Brech, Harald Stenmark, Camilla Raiborg, Andreas Carlson
Published in: Proceedings of the National Academy of Sciences, Issue 117/46, 2020, Page(s) 28614-28624, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2014228117

A phosphoinositide kinase triggers migrasmome formation

Author(s): Yan Zhen, Harald Stenmark
Published in: Cell Research, 2023, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press

The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

Author(s): Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark
Published in: Nature Communications, Issue 12, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26775-x

Crowding-Regulated Binding of Divalent Biomolecules

Author(s): Tomasz Skóra, Mathijs Janssen, Andreas Carlson, Svyatoslav Kondrat
Published in: Physical Review Letters, Issue 130, 2025, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.130.258401

Divalent ligand-monovalent molecule binding

Author(s): Mathijs Janssen, Harald Stenmark, Andreas Carlson
Published in: Soft Matter, Issue 17/21, 2021, Page(s) 5375-5383, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sm00070e

Sealing holes in cellular membranes

Author(s): Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Published in: The EMBO Journal, Issue 40/7, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020106922

ER as master regulator of membrane trafficking and organelle function

Author(s): Eva Maria Wenzel; Liv Anker Elfmark; Harald Stenmark; Camilla Raiborg
Published in: Journal of Cell Biology, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205135

ESCRT-mediated phagophore sealing during mitophagy

Author(s): Yan Zhen, Hélène Spangenberg, Michael J. Munson, Andreas Brech, Kay O. Schink, Kia-Wee Tan, Vigdis Sørensen, Eva Maria Wenzel, Maja Radulovic, Nikolai Engedal, Anne Simonsen, Camilla Raiborg, Harald Stenmark
Published in: Autophagy, Issue 16/5, 2020, Page(s) 826-841, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2019.1639301

A dual-purpose fusion complex in autophagy

Author(s): Yan Zhen, Harald Stenmark
Published in: Cell Research, 2024, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press

ATPase activity of DFCP1 controls selective autophagy

Author(s): Viola Nähse, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T. Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group

Wetting regulates autophagy of phase-separated compartments and the cytosol

Author(s): Jaime Agudo-Canalejo, Sebastian W. Schultz, Haruka Chino, Simona M. Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I. May, Noboru Mizushima, Roland L. Knorr
Published in: Nature, Issue 591/7848, 2021, Page(s) 142-146, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2992-3

ATPase-regulated autophagosome biogenesis

Author(s): Viola Nähse, Kay O. Schink, Harald Stenmark
Published in: Autophagy, Issue 20, 2024, Page(s) 218-219, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2023.2255967

LRRK 2 to the rescue of damaged endomembranes

Author(s): Maja Radulovic, Harald Stenmark
Published in: The EMBO Journal, Issue 39/18, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020106162

STEEP mediates STING ER exit and activation of signaling

Author(s): Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphael
Published in: Nature Immunology, Issue 21/8, 2020, Page(s) 868-879, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0730-5

Stability of a biomembrane tube covered with proteins

Author(s): Mathijs Janssen, Susanne Liese, Sami C. Al-Izzi, Andreas Carlson
Published in: Physical Review E, Issue 109, 2024, ISSN 2470-0045
Publisher: American Physical Society (APS)
DOI: 10.1103/physreve.109.044403

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

Author(s): Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
Published in: Journal of Cell Science, Issue 134/3, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250670

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

Author(s): Marina Vietri, Sebastian W. Schultz, Aurélie Bellanger, Carl M. Jones, Louise I. Petersen, Camilla Raiborg, Ellen Skarpen, Christeen Ramane J. Pedurupillay, Ingrid Kjos, Eline Kip, Romy Timmer, Ashish Jain, Philippe Collas, Roland L. Knorr, Sushma N. Grellscheid, Halim Kusumaatmaja, Andreas Brech, Francesca Micci, Harald Stenmark, Coen Campsteijn
Published in: Nature Cell Biology, Issue 22, 2023, Page(s) 856-867, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0537-5

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Author(s): Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10794-w

Coming together to define membrane contact sites

Author(s): Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09253-3

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

Author(s): Sascha Pust, Andreas Brech, Catherine Sem Wegner, Harald Stenmark, Kaisa Haglund
Published in: Cellular and Molecular Life Sciences, Issue 80, 2023, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-023-04864-y

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Author(s): Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg
Published in: Journal of Cell Biology, Issue 219/8, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202003063

PHLPP1 regulates CFTR activity and lumen expansion through AMPK

Author(s): Viola Lobert, Maren Skardal, Lene Malerød, Julie Elisabeth Simensen, Hermine Arida Algra, Aram Nikolai Andersen, Thomas Fleischer, Hilde A. Enserink, Knut Liestøl, Joan K. Heath, Tor Erik Rusten, Harald Stenmark
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.200955

Autophagosome Biogenesis

Author(s): Yan Zhen; Harald Stenmark
Published in: Cells, Issue 1, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12040668

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Author(s): Jodie P. Goodridge, Benedikt Jacobs, Michelle L. Saetersmoen, Dennis Clement, Quirin Hammer, Trevor Clancy, Ellen Skarpen, Andreas Brech, Johannes Landskron, Christian Grimm, Aline Pfefferle, Leonardo Meza-Zepeda, Susanne Lorenz, Merete Thune Wiiger, William E. Louch, Eivind Heggernes Ask, Lisa L. Liu, Vincent Yi Sheng Oei, Una Kjällquist, Sten Linnarsson, Sandip Patel, Kjetil Taskén, Harald Ste
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08384-x

Protrudin-mediated ER-endosome contact sites promote phagocytosis

Author(s): Liv Anker Elfmark, Eva Maria Wenzel, Ling Wang, Nina Marie Pedersen, Harald Stenmark, Camilla Raiborg
Published in: Cellular and Molecular Life Sciences, Issue 80, 2023, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-023-04862-0

The many functions of ESCRTs

Author(s): Marina Vietri, Maja Radulovic, Harald Stenmark
Published in: Nature Reviews Molecular Cell Biology, Issue 21/1, 2020, Page(s) 25-42, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0177-4

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Author(s): Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16143-6

Other (1)

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes

Author(s): Kia Wee Tan, Viola Nähse, Coen Campsteijn, Andreas Brech, Kay Oliver Schink, Harald Stenmark
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.29.319111

Non-peer reviewed articles (1)

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

Author(s): Anthony Ravussin, Sharon A. Tooze, Harald Stenmark
Published in: Journal of Cell Science, 2024, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1101/2020.06.24.169193

Conference proceedings (1)

A phosphoinositide and RAB switch controls early macropinocytosis

Author(s): Hélène Spangenberg, Marte Sneeggen, Maria Mateo Tortola, Camila Valenzuela, Yuen-Yan Chang, Harald Stenmark, Camilla Raiborg, Kay Oliver Schink
Published in: 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.11.03.467145