Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics

Información del proyecto

CODE

Identificador del acuerdo de subvención: 788954

DOI 10.3030/788954

Fecha de la firma de la CE 31 Mayo 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 500 000,00

Aportación de la UE € 2 500 000,00

Coordinado por

UNIVERSITETET I OSLO
Norway

Publicaciones

Peer reviewed articles (23)

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

Autores: Maja Radulovic, Eva Maria Wenzel, Sania Gilani, Lya KK Holland, Alf Håkon Lystad, Santosh Phuyal, Vesa M. Olkkonen, Andreas Brech, Marja Jäättelä, Kenji Maeda, Camilla Raiborg, Harald Stenmark
Publicado en: EMBO Journal, 2022, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2022112677

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Autores: Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.51063

ESCRTed resistance to T cell attack

Autores: Simona Maria Migliano, Harald Stenmark
Publicado en: Trends in Immunology, 2022, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2022.06.007

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

Autores: Astrid Skjesol, Mariia Yurchenko, Korbinian Bösl, Caroline Gravastrand, Kaja Elisabeth Nilsen, Lene Melsæther Grøvdal, Federica Agliano, Francesco Patane, Germana Lentini, Hera Kim, Giuseppe Teti, Aditya Kumar Sharma, Richard K. Kandasamy, Bjørnar Sporsheim, Kristian K. Starheim, Douglas T. Golenbock, Harald Stenmark, Mary McCaffrey, Terje Espevik, Harald Husebye
Publicado en: PLOS Pathogens, Edición 15/3, 2019, Página(s) e1007684, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1007684

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Autores: Simona Maria Migliano, Eva Maria Wenzel, Harald Stenmark
Publicado en: Current Opinion in Cell Biology, 2022, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2022.01.007

Tumor suppression by control of matrix metalloproteinase recycling

Autores: Marte Sneeggen, Kay O. Schink, Harald Stenmark
Publicado en: Molecular & Cellular Oncology, Edición 6/6, 2019, Página(s) e1646606, ISSN 2372-3556
Editor: Frontiers Media SA
DOI: 10.1080/23723556.2019.1646606

Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles

Autores: Susanne Liese, Eva Maria Wenzel, Ingrid Kjos, Rossana Rojas Molina, Sebastian W. Schultz, Andreas Brech, Harald Stenmark, Camilla Raiborg, Andreas Carlson
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/46, 2020, Página(s) 28614-28624, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2014228117

Divalent ligand-monovalent molecule binding

Autores: Mathijs Janssen, Harald Stenmark, Andreas Carlson
Publicado en: Soft Matter, Edición 17/21, 2021, Página(s) 5375-5383, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sm00070e

Sealing holes in cellular membranes

Autores: Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Publicado en: The EMBO Journal, Edición 40/7, 2021, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020106922

ER as master regulator of membrane trafficking and organelle function

Autores: Eva Maria Wenzel; Liv Anker Elfmark; Harald Stenmark; Camilla Raiborg
Publicado en: Journal of Cell Biology, 2022, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202205135

ESCRT-mediated phagophore sealing during mitophagy

Autores: Yan Zhen, Hélène Spangenberg, Michael J. Munson, Andreas Brech, Kay O. Schink, Kia-Wee Tan, Vigdis Sørensen, Eva Maria Wenzel, Maja Radulovic, Nikolai Engedal, Anne Simonsen, Camilla Raiborg, Harald Stenmark
Publicado en: Autophagy, Edición 16/5, 2020, Página(s) 826-841, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2019.1639301

Wetting regulates autophagy of phase-separated compartments and the cytosol

Autores: Jaime Agudo-Canalejo, Sebastian W. Schultz, Haruka Chino, Simona M. Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I. May, Noboru Mizushima, Roland L. Knorr
Publicado en: Nature, Edición 591/7848, 2021, Página(s) 142-146, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2992-3

LRRK 2 to the rescue of damaged endomembranes

Autores: Maja Radulovic, Harald Stenmark
Publicado en: The EMBO Journal, Edición 39/18, 2020, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020106162

STEEP mediates STING ER exit and activation of signaling

Autores: Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphael
Publicado en: Nature Immunology, Edición 21/8, 2020, Página(s) 868-879, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0730-5

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

Autores: Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
Publicado en: Journal of Cell Science, Edición 134/3, 2021, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250670

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Autores: Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-10794-w

Coming together to define membrane contact sites

Autores: Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09253-3

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Autores: Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg
Publicado en: Journal of Cell Biology, Edición 219/8, 2020, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202003063

PHLPP1 regulates CFTR activity and lumen expansion through AMPK

Autores: Viola Lobert, Maren Skardal, Lene Malerød, Julie Elisabeth Simensen, Hermine Arida Algra, Aram Nikolai Andersen, Thomas Fleischer, Hilde A. Enserink, Knut Liestøl, Joan K. Heath, Tor Erik Rusten, Harald Stenmark
Publicado en: Development, 2022, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.200955

Autophagosome Biogenesis

Autores: Yan Zhen; Harald Stenmark
Publicado en: Cells, Edición 1, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12040668

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Autores: Jodie P. Goodridge, Benedikt Jacobs, Michelle L. Saetersmoen, Dennis Clement, Quirin Hammer, Trevor Clancy, Ellen Skarpen, Andreas Brech, Johannes Landskron, Christian Grimm, Aline Pfefferle, Leonardo Meza-Zepeda, Susanne Lorenz, Merete Thune Wiiger, William E. Louch, Eivind Heggernes Ask, Lisa L. Liu, Vincent Yi Sheng Oei, Una Kjällquist, Sten Linnarsson, Sandip Patel, Kjetil Taskén, Harald Ste
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08384-x

The many functions of ESCRTs

Autores: Marina Vietri, Maja Radulovic, Harald Stenmark
Publicado en: Nature Reviews Molecular Cell Biology, Edición 21/1, 2020, Página(s) 25-42, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-019-0177-4

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Autores: Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16143-6