Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics

Información del proyecto

CODE

Identificador del acuerdo de subvención: 788954

DOI

10.3030/788954

Proyecto cerrado

Fecha de la firma de la CE 31 Mayo 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UNIVERSITETET I OSLO
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (38)

Lysophagy prevents neurotoxic aggregate transmission

Autores: Maja Radulovic, Harald Stenmark
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2321181121

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

Autores: Maja Radulovic, Eva Maria Wenzel, Sania Gilani, Lya KK Holland, Alf Håkon Lystad, Santosh Phuyal, Vesa M. Olkkonen, Andreas Brech, Marja Jäättelä, Kenji Maeda, Camilla Raiborg, Harald Stenmark
Publicado en: EMBO Journal, 2022, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2022112677

<scp>TECPR1</scp> is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

Autores: Namrita Kaur, Laura Rodriguez de la Ballina, Håvard Styrkestad Haukaas, Maria Lyngaas Torgersen, Maja Radulovic, Michael J Munson, Alan Sabirsh, Harald Stenmark, Anne Simonsen, Sven R Carlsson, Alf Håkon Lystad
Publicado en: The EMBO Journal, Edición 42, 2023, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2022113105

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Autores: Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.51063

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Autores: Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45558-8

ESCRTed resistance to T cell attack

Autores: Simona Maria Migliano, Harald Stenmark
Publicado en: Trends in Immunology, 2022, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2022.06.007

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

Autores: Astrid Skjesol, Mariia Yurchenko, Korbinian Bösl, Caroline Gravastrand, Kaja Elisabeth Nilsen, Lene Melsæther Grøvdal, Federica Agliano, Francesco Patane, Germana Lentini, Hera Kim, Giuseppe Teti, Aditya Kumar Sharma, Richard K. Kandasamy, Bjørnar Sporsheim, Kristian K. Starheim, Douglas T. Golenbock, Harald Stenmark, Mary McCaffrey, Terje Espevik, Harald Husebye
Publicado en: PLOS Pathogens, Edición 15/3, 2019, Página(s) e1007684, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1007684

Exosome regulation by Rubicon in ageing

Autores: Yan Zhen, Harald Stenmark
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 1380-1381, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01482-z

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Autores: Simona Maria Migliano, Eva Maria Wenzel, Harald Stenmark
Publicado en: Current Opinion in Cell Biology, 2022, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2022.01.007

Removal of hypersignaling endosomes by simaphagy

Autores: Simona M. Migliano, Sebastian W. Schultz, Eva M. Wenzel, Szabolcs Takáts, Dan Liu, Silje Mørk, Kia Wee Tan, Tor Erik Rusten, Camilla Raiborg, Harald Stenmark
Publicado en: Autophagy, Edición 20, 2024, Página(s) 769-791, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2023.2267958

Tumor suppression by control of matrix metalloproteinase recycling

Autores: Marte Sneeggen, Kay O. Schink, Harald Stenmark
Publicado en: Molecular & Cellular Oncology, Edición 6/6, 2019, Página(s) e1646606, ISSN 2372-3556
Editor: Frontiers Media SA
DOI: 10.1080/23723556.2019.1646606

Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles

Autores: Susanne Liese, Eva Maria Wenzel, Ingrid Kjos, Rossana Rojas Molina, Sebastian W. Schultz, Andreas Brech, Harald Stenmark, Camilla Raiborg, Andreas Carlson
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/46, 2020, Página(s) 28614-28624, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2014228117

A phosphoinositide kinase triggers migrasmome formation

Autores: Yan Zhen, Harald Stenmark
Publicado en: Cell Research, 2023, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press

The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

Autores: Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark
Publicado en: Nature Communications, Edición 12, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26775-x

Crowding-Regulated Binding of Divalent Biomolecules

Autores: Tomasz Skóra, Mathijs Janssen, Andreas Carlson, Svyatoslav Kondrat
Publicado en: Physical Review Letters, Edición 130, 2025, ISSN 0031-9007
Editor: American Physical Society
DOI: 10.1103/physrevlett.130.258401

Divalent ligand-monovalent molecule binding

Autores: Mathijs Janssen, Harald Stenmark, Andreas Carlson
Publicado en: Soft Matter, Edición 17/21, 2021, Página(s) 5375-5383, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sm00070e

Sealing holes in cellular membranes

Autores: Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Publicado en: The EMBO Journal, Edición 40/7, 2021, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020106922

ER as master regulator of membrane trafficking and organelle function

Autores: Eva Maria Wenzel; Liv Anker Elfmark; Harald Stenmark; Camilla Raiborg
Publicado en: Journal of Cell Biology, 2022, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202205135

ESCRT-mediated phagophore sealing during mitophagy

Autores: Yan Zhen, Hélène Spangenberg, Michael J. Munson, Andreas Brech, Kay O. Schink, Kia-Wee Tan, Vigdis Sørensen, Eva Maria Wenzel, Maja Radulovic, Nikolai Engedal, Anne Simonsen, Camilla Raiborg, Harald Stenmark
Publicado en: Autophagy, Edición 16/5, 2020, Página(s) 826-841, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2019.1639301

A dual-purpose fusion complex in autophagy

Autores: Yan Zhen, Harald Stenmark
Publicado en: Cell Research, 2024, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press

ATPase activity of DFCP1 controls selective autophagy

Autores: Viola Nähse, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T. Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group

Wetting regulates autophagy of phase-separated compartments and the cytosol

Autores: Jaime Agudo-Canalejo, Sebastian W. Schultz, Haruka Chino, Simona M. Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I. May, Noboru Mizushima, Roland L. Knorr
Publicado en: Nature, Edición 591/7848, 2021, Página(s) 142-146, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2992-3

ATPase-regulated autophagosome biogenesis

Autores: Viola Nähse, Kay O. Schink, Harald Stenmark
Publicado en: Autophagy, Edición 20, 2024, Página(s) 218-219, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2023.2255967

LRRK 2 to the rescue of damaged endomembranes

Autores: Maja Radulovic, Harald Stenmark
Publicado en: The EMBO Journal, Edición 39/18, 2020, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020106162

STEEP mediates STING ER exit and activation of signaling

Autores: Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphael
Publicado en: Nature Immunology, Edición 21/8, 2020, Página(s) 868-879, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0730-5

Stability of a biomembrane tube covered with proteins

Autores: Mathijs Janssen, Susanne Liese, Sami C. Al-Izzi, Andreas Carlson
Publicado en: Physical Review E, Edición 109, 2024, ISSN 2470-0045
Editor: American Physical Society (APS)
DOI: 10.1103/physreve.109.044403

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

Autores: Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
Publicado en: Journal of Cell Science, Edición 134/3, 2021, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250670

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

Autores: Marina Vietri, Sebastian W. Schultz, Aurélie Bellanger, Carl M. Jones, Louise I. Petersen, Camilla Raiborg, Ellen Skarpen, Christeen Ramane J. Pedurupillay, Ingrid Kjos, Eline Kip, Romy Timmer, Ashish Jain, Philippe Collas, Roland L. Knorr, Sushma N. Grellscheid, Halim Kusumaatmaja, Andreas Brech, Francesca Micci, Harald Stenmark, Coen Campsteijn
Publicado en: Nature Cell Biology, Edición 22, 2023, Página(s) 856-867, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-020-0537-5

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Autores: Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-10794-w

Coming together to define membrane contact sites

Autores: Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09253-3

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

Autores: Sascha Pust, Andreas Brech, Catherine Sem Wegner, Harald Stenmark, Kaisa Haglund
Publicado en: Cellular and Molecular Life Sciences, Edición 80, 2023, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-023-04864-y

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Autores: Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg
Publicado en: Journal of Cell Biology, Edición 219/8, 2020, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202003063

PHLPP1 regulates CFTR activity and lumen expansion through AMPK

Autores: Viola Lobert, Maren Skardal, Lene Malerød, Julie Elisabeth Simensen, Hermine Arida Algra, Aram Nikolai Andersen, Thomas Fleischer, Hilde A. Enserink, Knut Liestøl, Joan K. Heath, Tor Erik Rusten, Harald Stenmark
Publicado en: Development, 2022, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.200955

Autophagosome Biogenesis

Autores: Yan Zhen; Harald Stenmark
Publicado en: Cells, Edición 1, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12040668

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Autores: Jodie P. Goodridge, Benedikt Jacobs, Michelle L. Saetersmoen, Dennis Clement, Quirin Hammer, Trevor Clancy, Ellen Skarpen, Andreas Brech, Johannes Landskron, Christian Grimm, Aline Pfefferle, Leonardo Meza-Zepeda, Susanne Lorenz, Merete Thune Wiiger, William E. Louch, Eivind Heggernes Ask, Lisa L. Liu, Vincent Yi Sheng Oei, Una Kjällquist, Sten Linnarsson, Sandip Patel, Kjetil Taskén, Harald Ste
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08384-x

Protrudin-mediated ER-endosome contact sites promote phagocytosis

Autores: Liv Anker Elfmark, Eva Maria Wenzel, Ling Wang, Nina Marie Pedersen, Harald Stenmark, Camilla Raiborg
Publicado en: Cellular and Molecular Life Sciences, Edición 80, 2023, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-023-04862-0

The many functions of ESCRTs

Autores: Marina Vietri, Maja Radulovic, Harald Stenmark
Publicado en: Nature Reviews Molecular Cell Biology, Edición 21/1, 2020, Página(s) 25-42, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-019-0177-4

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Autores: Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16143-6

Other (1)

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes

Autores: Kia Wee Tan, Viola Nähse, Coen Campsteijn, Andreas Brech, Kay Oliver Schink, Harald Stenmark
Publicado en: bioRxiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.29.319111

Non-peer reviewed articles (1)

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

Autores: Anthony Ravussin, Sharon A. Tooze, Harald Stenmark
Publicado en: Journal of Cell Science, 2024, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1101/2020.06.24.169193

Conference proceedings (1)

A phosphoinositide and RAB switch controls early macropinocytosis

Autores: Hélène Spangenberg, Marte Sneeggen, Maria Mateo Tortola, Camila Valenzuela, Yuen-Yan Chang, Harald Stenmark, Camilla Raiborg, Kay Oliver Schink
Publicado en: 2023
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.11.03.467145