Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics

Lysophagy prevents neurotoxic aggregate transmission

Autori: Maja Radulovic, Harald Stenmark
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2321181121

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

Autori: Maja Radulovic, Eva Maria Wenzel, Sania Gilani, Lya KK Holland, Alf Håkon Lystad, Santosh Phuyal, Vesa M. Olkkonen, Andreas Brech, Marja Jäättelä, Kenji Maeda, Camilla Raiborg, Harald Stenmark
Pubblicato in: EMBO Journal, 2022, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022112677

<scp>TECPR1</scp> is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

Autori: Namrita Kaur, Laura Rodriguez de la Ballina, Håvard Styrkestad Haukaas, Maria Lyngaas Torgersen, Maja Radulovic, Michael J Munson, Alan Sabirsh, Harald Stenmark, Anne Simonsen, Sven R Carlsson, Alf Håkon Lystad
Pubblicato in: The EMBO Journal, Numero 42, 2023, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022113105

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Autori: Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals
Pubblicato in: eLife, Numero 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.51063

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Autori: Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-45558-8

ESCRTed resistance to T cell attack

Autori: Simona Maria Migliano, Harald Stenmark
Pubblicato in: Trends in Immunology, 2022, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2022.06.007

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

Autori: Astrid Skjesol, Mariia Yurchenko, Korbinian Bösl, Caroline Gravastrand, Kaja Elisabeth Nilsen, Lene Melsæther Grøvdal, Federica Agliano, Francesco Patane, Germana Lentini, Hera Kim, Giuseppe Teti, Aditya Kumar Sharma, Richard K. Kandasamy, Bjørnar Sporsheim, Kristian K. Starheim, Douglas T. Golenbock, Harald Stenmark, Mary McCaffrey, Terje Espevik, Harald Husebye
Pubblicato in: PLOS Pathogens, Numero 15/3, 2019, Pagina/e e1007684, ISSN 1553-7374
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1007684

Exosome regulation by Rubicon in ageing

Autori: Yan Zhen, Harald Stenmark
Pubblicato in: Nature Cell Biology, Numero 26, 2024, Pagina/e 1380-1381, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01482-z

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Autori: Simona Maria Migliano, Eva Maria Wenzel, Harald Stenmark
Pubblicato in: Current Opinion in Cell Biology, 2022, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2022.01.007

Removal of hypersignaling endosomes by simaphagy

Autori: Simona M. Migliano, Sebastian W. Schultz, Eva M. Wenzel, Szabolcs Takáts, Dan Liu, Silje Mørk, Kia Wee Tan, Tor Erik Rusten, Camilla Raiborg, Harald Stenmark
Pubblicato in: Autophagy, Numero 20, 2024, Pagina/e 769-791, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2023.2267958

Tumor suppression by control of matrix metalloproteinase recycling

Autori: Marte Sneeggen, Kay O. Schink, Harald Stenmark
Pubblicato in: Molecular & Cellular Oncology, Numero 6/6, 2019, Pagina/e e1646606, ISSN 2372-3556
Editore: Frontiers Media SA
DOI: 10.1080/23723556.2019.1646606

Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles

Autori: Susanne Liese, Eva Maria Wenzel, Ingrid Kjos, Rossana Rojas Molina, Sebastian W. Schultz, Andreas Brech, Harald Stenmark, Camilla Raiborg, Andreas Carlson
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/46, 2020, Pagina/e 28614-28624, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2014228117

A phosphoinositide kinase triggers migrasmome formation

Autori: Yan Zhen, Harald Stenmark
Pubblicato in: Cell Research, 2023, ISSN 1001-0602
Editore: Kexue Chubaneshe/Science Press

The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

Autori: Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark
Pubblicato in: Nature Communications, Numero 12, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26775-x

Crowding-Regulated Binding of Divalent Biomolecules

Autori: Tomasz Skóra, Mathijs Janssen, Andreas Carlson, Svyatoslav Kondrat
Pubblicato in: Physical Review Letters, Numero 130, 2025, ISSN 0031-9007
Editore: American Physical Society
DOI: 10.1103/physrevlett.130.258401

Divalent ligand-monovalent molecule binding

Autori: Mathijs Janssen, Harald Stenmark, Andreas Carlson
Pubblicato in: Soft Matter, Numero 17/21, 2021, Pagina/e 5375-5383, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sm00070e

Sealing holes in cellular membranes

Autori: Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Pubblicato in: The EMBO Journal, Numero 40/7, 2021, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020106922

ER as master regulator of membrane trafficking and organelle function

Autori: Eva Maria Wenzel; Liv Anker Elfmark; Harald Stenmark; Camilla Raiborg
Pubblicato in: Journal of Cell Biology, 2022, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202205135

ESCRT-mediated phagophore sealing during mitophagy

Autori: Yan Zhen, Hélène Spangenberg, Michael J. Munson, Andreas Brech, Kay O. Schink, Kia-Wee Tan, Vigdis Sørensen, Eva Maria Wenzel, Maja Radulovic, Nikolai Engedal, Anne Simonsen, Camilla Raiborg, Harald Stenmark
Pubblicato in: Autophagy, Numero 16/5, 2020, Pagina/e 826-841, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2019.1639301

A dual-purpose fusion complex in autophagy

Autori: Yan Zhen, Harald Stenmark
Pubblicato in: Cell Research, 2024, ISSN 1001-0602
Editore: Kexue Chubaneshe/Science Press

Wetting regulates autophagy of phase-separated compartments and the cytosol

Autori: Jaime Agudo-Canalejo, Sebastian W. Schultz, Haruka Chino, Simona M. Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I. May, Noboru Mizushima, Roland L. Knorr
Pubblicato in: Nature, Numero 591/7848, 2021, Pagina/e 142-146, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2992-3

ATPase-regulated autophagosome biogenesis

Autori: Viola Nähse, Kay O. Schink, Harald Stenmark
Pubblicato in: Autophagy, Numero 20, 2024, Pagina/e 218-219, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2023.2255967

LRRK 2 to the rescue of damaged endomembranes

Autori: Maja Radulovic, Harald Stenmark
Pubblicato in: The EMBO Journal, Numero 39/18, 2020, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020106162

STEEP mediates STING ER exit and activation of signaling

Autori: Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphael
Pubblicato in: Nature Immunology, Numero 21/8, 2020, Pagina/e 868-879, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-020-0730-5

Stability of a biomembrane tube covered with proteins

Autori: Mathijs Janssen, Susanne Liese, Sami C. Al-Izzi, Andreas Carlson
Pubblicato in: Physical Review E, Numero 109, 2024, ISSN 2470-0045
Editore: American Physical Society (APS)
DOI: 10.1103/physreve.109.044403

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

Autori: Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
Pubblicato in: Journal of Cell Science, Numero 134/3, 2021, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250670

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Autori: Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-10794-w

Coming together to define membrane contact sites

Autori: Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09253-3

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

Autori: Sascha Pust, Andreas Brech, Catherine Sem Wegner, Harald Stenmark, Kaisa Haglund
Pubblicato in: Cellular and Molecular Life Sciences, Numero 80, 2023, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-023-04864-y

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Autori: Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg
Pubblicato in: Journal of Cell Biology, Numero 219/8, 2020, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202003063

PHLPP1 regulates CFTR activity and lumen expansion through AMPK

Autori: Viola Lobert, Maren Skardal, Lene Malerød, Julie Elisabeth Simensen, Hermine Arida Algra, Aram Nikolai Andersen, Thomas Fleischer, Hilde A. Enserink, Knut Liestøl, Joan K. Heath, Tor Erik Rusten, Harald Stenmark
Pubblicato in: Development, 2022, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.200955

Autophagosome Biogenesis

Autori: Yan Zhen; Harald Stenmark
Pubblicato in: Cells, Numero 1, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12040668

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Autori: Jodie P. Goodridge, Benedikt Jacobs, Michelle L. Saetersmoen, Dennis Clement, Quirin Hammer, Trevor Clancy, Ellen Skarpen, Andreas Brech, Johannes Landskron, Christian Grimm, Aline Pfefferle, Leonardo Meza-Zepeda, Susanne Lorenz, Merete Thune Wiiger, William E. Louch, Eivind Heggernes Ask, Lisa L. Liu, Vincent Yi Sheng Oei, Una Kjällquist, Sten Linnarsson, Sandip Patel, Kjetil Taskén, Harald Ste
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08384-x

Protrudin-mediated ER-endosome contact sites promote phagocytosis

Autori: Liv Anker Elfmark, Eva Maria Wenzel, Ling Wang, Nina Marie Pedersen, Harald Stenmark, Camilla Raiborg
Pubblicato in: Cellular and Molecular Life Sciences, Numero 80, 2023, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-023-04862-0

The many functions of ESCRTs

Autori: Marina Vietri, Maja Radulovic, Harald Stenmark
Pubblicato in: Nature Reviews Molecular Cell Biology, Numero 21/1, 2020, Pagina/e 25-42, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-019-0177-4

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Autori: Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16143-6

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes

Autori: Kia Wee Tan, Viola Nähse, Coen Campsteijn, Andreas Brech, Kay Oliver Schink, Harald Stenmark
Pubblicato in: bioRxiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.29.319111

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

Autori: Anthony Ravussin, Sharon A. Tooze, Harald Stenmark
Pubblicato in: Journal of Cell Science, 2024, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1101/2020.06.24.169193

A phosphoinositide and RAB switch controls early macropinocytosis

Autori: Hélène Spangenberg, Marte Sneeggen, Maria Mateo Tortola, Camila Valenzuela, Yuen-Yan Chang, Harald Stenmark, Camilla Raiborg, Kay Oliver Schink
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.11.03.467145

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