Novel Coding Factors in Heart Disease

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A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

Autori: Bjoern Gaertner, Sebastiaan van Heesch, Valentin Schneider-Lunitz, Jana Felicitas Schulz, Franziska Witte, Susanne Blachut, Steven Nguyen, Regina Wong, Ileana Matta, Norbert Hübner, Maike Sander
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.58659

Evolution and implications of de novo genes in humans.

Autori: Broeils LA, Ruiz-Orera J, Snel B, Hubner N, van Heesch S.
Pubblicato in: Nat Ecol Evol, 2023, ISSN 2397-334X
Editore: Springer Nature
DOI: 10.1038/s41559-023-02014-y

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

Autori: Valentin Schneider-Lunitz; Jorge Ruiz-Orera; Norbert Hubner; Sebastiaan van Heesch
Pubblicato in: Plos Computational Biology, Numero 1, 2021, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1009658

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.

Autori: Ansari, S.A.; Dantoft, W.; Ruiz-Orera, J.; Syed, A.P.; Blachut, S.; van Heesch, S.; Hübner, N.; Uhlenhaut, N.H.
Pubblicato in: Comp. Struc. Biotech. J. 20, 5622-5638 (2022), Numero 3, 2022, Pagina/e 5622-5638, ISSN 2001-0370
Editore: Science Direct
DOI: 10.1016/j.csbj.2022.09.042

Standardized annotation of translated open reading frames.

Autori: Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S
Pubblicato in: Nat Biotechnol., Numero Jul;40(7):994-999, 2022, Pagina/e 994-999, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-022-01369-0

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

Autori: Ercu M, Mücke MB, Pallien T, Markó L, Sholokh A, Schächterle C, Aydin A, Kidd A, Walter S, Esmati Y, McMurray BJ, Lato DF, Yumi Sunaga-Franze D, Dierks PH, Flores BIM, Walker-Gray R, Gong M, Merticariu C, Zühlke K, Russwurm M, Liu T, Batolomaeus TUP, Pautz S, Schelenz S, Taube M, Napieczynska H, Heuser A, Eichhorst J, Lehmann M, Miller DC, Diecke S, Qadri F, Popova E, Langanki R, Movsesian MA,
Pubblicato in: Circulation, Numero Dec 6;146(23):1758-1778, 2022, Pagina/e 1758-1778, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.060210

The Translational Landscape of the Human Heart

Autori: Sebastiaan van Heesch, Franziska Witte, Valentin Schneider-Lunitz, Jana F. Schulz, Eleonora Adami, Allison B. Faber, Marieluise Kirchner, Henrike Maatz, Susanne Blachut, Clara-Louisa Sandmann, Masatoshi Kanda, Catherine L. Worth, Sebastian Schafer, Lorenzo Calviello, Rhys Merriott, Giannino Patone, Oliver Hummel, Emanuel Wyler, Benedikt Obermayer, Michael B. Mücke, Eric L. Lindberg, Franziska Trn
Pubblicato in: Cell, Numero 178/1, 2019, Pagina/e 242-260.e29, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.05.010

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Autori: Witte, Franziska; Ruiz-Orera, Jorge; Mattioli, Camilla Ciolli; Blachut, Susanne; Adami, Eleonora; Schulz, Jana Felicitas; Schneider-Lunitz, Valentin; Hummel, Oliver; Patone, Giannino; Mücke, Michael Benedikt; Šilhavý, Jan; Heinig, Matthias; Bottolo, Leonardo; Sanchis, Daniel; Vingron, Martin; Chekulaeva, Marina; Pravenec, Michal; Hubner, Norbert; Van Heesch, Sebastiaan
Pubblicato in: Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021), Numero 3, 2021, ISSN 1474-760X
Editore: biomedcentral
DOI: 10.17863/cam.71948

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

Autori: C.L. Sandmann, J.F. Schulz, J. Ruiz-Orera, M. Kirchner, M. Ziehm, E. Adami, M. Marczenke, A. Christ, N. Liebe, J. Greiner, A. Schoenenberger, M.B. Mücke, N. Liang, R.L. Moritz, Z. Sun, E.W. Deutsch, M. Gotthardt, J.M. Mudge, J.R. Prensner, T.E. Willnow, P. Mertins, S. van Heesch, N. Hubner
Pubblicato in: Mol Cell, 2023, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2023.01.023

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Autori: Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F,
Pubblicato in: Science, Numero Aug 5;377(6606):eabo1984., 2022, Pagina/e 377, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abo1984

Cells of the adult human heart

Autori: Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Jose
Pubblicato in: Nature, 2020, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2797-4

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