Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Project Information

DYNACOTINE

Grant agreement ID: 788974

DOI 10.3030/788974

EC signature date 18 July 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 282 105,00

EU contribution € 2 282 105,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Publications

Peer reviewed articles (6)

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

Author(s): Marie S. Prevost, Hichem Bouchenaki, Nathalie Barilone, Marc Gielen, Pierre-Jean Corringer
Published in: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-020-03558-z

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Author(s): Solène N Lefebvre; Antoine Taly; Anaïs Menny; Karima Medjebeur; Pierre-Jean Corringer
Published in: eLife, Issue 3, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60682

The desensitization pathway of GABAA receptors, one subunit at a time

Author(s): Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19218-6

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Author(s): Cerdan, Adrien H.; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco
Published in: Science Advances, Issue 2, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9340

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Author(s): Sophie Shi; Solène N. Lefebvre; Laurie Peverini; Adrien H. Cerdan; Paula Milán Rodríguez; Marc Gielen; Jean-Pierre Changeux; Marco Cecchini; Pierre-Jean Corringer
Published in: Nature Communications, Issue 1, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36471-7

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Author(s): Li Q, Nemecz A, Aymé G, Dejean de la Bâtie G, Prevost MS, Pons S, Barilone N, Baachaoui R, Maskos U, Lafaye P, Corringer PJ
Published in: cellular and molecular life science, Issue 3, 2023, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-023-04779-8