Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Informazioni relative al progetto

DYNACOTINE

ID dell’accordo di sovvenzione: 788974

DOI

10.3030/788974

Progetto chiuso

Data della firma CE 18 Luglio 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 282 105,00

Contributo UE

€ 2 282 105,00

Coordinato da

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (11)

The Nicotinic Acetylcholine Receptor and Its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level

Autori: Marco Cecchini, Pierre-Jean Corringer, Jean-Pierre Changeux
Pubblicato in: Annual Review of Biochemistry, Numero 93, 2024, Pagina/e 339-366, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030122-033116

An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies

Autori: Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean De La Batie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer
Pubblicato in: Nature Communication, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/2023.01.03.522595

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

Autori: Marie S. Prevost, Hichem Bouchenaki, Nathalie Barilone, Marc Gielen, Pierre-Jean Corringer
Pubblicato in: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-020-03558-z

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Autori: Solène N Lefebvre; Antoine Taly; Anaïs Menny; Karima Medjebeur; Pierre-Jean Corringer
Pubblicato in: eLife, Numero 3, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.60682

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

Autori: Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre-Jean Corringer
Pubblicato in: eLife, Numero 12, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.93174.3

The desensitization pathway of GABAA receptors, one subunit at a time

Autori: Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19218-6

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Autori: Cerdan, Adrien H.; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco
Pubblicato in: Science Advances, Numero 2, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9340

Neutralizing Nanobodies against Venoms from Naja haje Species Captured in North Africa

Autori: Hiba Mejri, Rym Mokrani, Ayoub Ksouri, Mabrouk Seddik, Nour Awad, Gabriel Ayme, Thouraya Chagour, Ahlem Mokrani, Charraf eddine Louchene, Imed Salhi, Rahma Ben Abderrazek, Rym Ben Khalifa, Zakaria Benlasfar, Pierre-Jean Corringer, Mohamed Hammadi, Selma Djilani, Pierre Lafaye, Balkiss Bouhaouala-Zahar
Pubblicato in: Toxins, Numero 16, 2025, Pagina/e 393, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins16090393

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Autori: Sophie Shi; Solène N. Lefebvre; Laurie Peverini; Adrien H. Cerdan; Paula Milán Rodríguez; Marc Gielen; Jean-Pierre Changeux; Marco Cecchini; Pierre-Jean Corringer
Pubblicato in: Nature Communications, Numero 1, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36471-7

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Autori: Li Q, Nemecz A, Aymé G, Dejean de la Bâtie G, Prevost MS, Pons S, Barilone N, Baachaoui R, Maskos U, Lafaye P, Corringer PJ
Pubblicato in: cellular and molecular life science, Numero 3, 2023, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-023-04779-8

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor<i>α</i>1

Autori: Alessio Bartocci, Andrea Grazzi, Nour Awad, Pierre-Jean Corringer, Paulo C.T. Souza, Marco Cecchini
Pubblicato in: Nature Communication, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/2023.04.19.537578

Diritti di proprietà intellettuale

Patent (1)

GENERATION OF ANTIBODIES ACTING AS SILENT AND POSITIVE ALLOSTERIC MODULATORS OF THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR

Numero candidatura/pubblicazione: 20 23000654
Data: 2023-11-10
Candidato/i: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS