Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Informazioni relative al progetto

DYNACOTINE

ID dell’accordo di sovvenzione: 788974

DOI 10.3030/788974

Data della firma CE 18 Luglio 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 282 105,00

Contributo UE € 2 282 105,00

Coordinato da

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Pubblicazioni

Peer reviewed articles (6)

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

Autori: Marie S. Prevost, Hichem Bouchenaki, Nathalie Barilone, Marc Gielen, Pierre-Jean Corringer
Pubblicato in: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-020-03558-z

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Autori: Solène N Lefebvre; Antoine Taly; Anaïs Menny; Karima Medjebeur; Pierre-Jean Corringer
Pubblicato in: eLife, Numero 3, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.60682

The desensitization pathway of GABAA receptors, one subunit at a time

Autori: Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19218-6

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Autori: Cerdan, Adrien H.; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco
Pubblicato in: Science Advances, Numero 2, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9340

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Autori: Sophie Shi; Solène N. Lefebvre; Laurie Peverini; Adrien H. Cerdan; Paula Milán Rodríguez; Marc Gielen; Jean-Pierre Changeux; Marco Cecchini; Pierre-Jean Corringer
Pubblicato in: Nature Communications, Numero 1, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36471-7

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Autori: Li Q, Nemecz A, Aymé G, Dejean de la Bâtie G, Prevost MS, Pons S, Barilone N, Baachaoui R, Maskos U, Lafaye P, Corringer PJ
Pubblicato in: cellular and molecular life science, Numero 3, 2023, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-023-04779-8