Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Publicaciones

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

Autores: Marie S. Prevost, Hichem Bouchenaki, Nathalie Barilone, Marc Gielen, Pierre-Jean Corringer
Publicado en: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-020-03558-z

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Autores: Solène N Lefebvre; Antoine Taly; Anaïs Menny; Karima Medjebeur; Pierre-Jean Corringer
Publicado en: eLife, Edición 3, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.60682

The desensitization pathway of GABAA receptors, one subunit at a time

Autores: Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19218-6

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Autores: Cerdan, Adrien H.; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco
Publicado en: Science Advances, Edición 2, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9340

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Autores: Sophie Shi; Solène N. Lefebvre; Laurie Peverini; Adrien H. Cerdan; Paula Milán Rodríguez; Marc Gielen; Jean-Pierre Changeux; Marco Cecchini; Pierre-Jean Corringer
Publicado en: Nature Communications, Edición 1, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36471-7

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Autores: Li Q, Nemecz A, Aymé G, Dejean de la Bâtie G, Prevost MS, Pons S, Barilone N, Baachaoui R, Maskos U, Lafaye P, Corringer PJ
Publicado en: cellular and molecular life science, Edición 3, 2023, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-023-04779-8

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