How MHC-I editing complexes shape the hierarchical immune response

Project Information

EditMHC

Grant agreement ID: 789121

DOI 10.3030/789121

EC signature date 11 July 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 181 250,00

EU contribution € 2 181 250,00

Coordinated by

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

Publications

Peer reviewed articles (16)

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

Author(s): Christian Winter; Alexander Domnick; Darja Cernova; Robert Tampé
Published in: Crossref, Issue 4, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211826

MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity

Author(s): Christoph Thomas, Robert Tampé
Published in: Current Opinion in Immunology, Issue 70, 2021, Page(s) 48-56, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2021.02.004

Structural and Mechanistic Principles of ABC Transporters

Author(s): Christoph Thomas, Robert Tampé
Published in: Annual Review of Biochemistry, Issue 89/1, 2020, Page(s) 605-636, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-011520-105201

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Author(s): Jamina Brunnberg; Valentina Herbring; Esteban Günther Castillo; Heike Krüger; Ralph Wieneke; Robert Tampé
Published in: Communications Biology, Issue 3, 2021, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.1038/s42003-021-01890-z

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Author(s): Lukas Susac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O'Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Published in: Cell, Issue Volume 185, Issue 17, 2022, Page(s) 3201-3213.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.010

Molecular basis of MHC I quality control in the peptide loading complex

Author(s): Alexander Domnick, Christian Winter, Lukas Susac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32384-z

Conformation space of a heterodimeric ABC exporter under turnover conditions

Author(s): Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Published in: Nature, Issue 571/7766, 2019, Page(s) 580-583, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1391-0

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

Author(s): Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55326

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Author(s): Erich Stefan, Susanne Hofmann, Robert Tampé
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55943

Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity

Author(s): Simon Trowitzsch, Robert Tampé
Published in: Annual Review of Biophysics, Issue 49/1, 2020, ISSN 1936-122X
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081643

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Author(s): Nicole Koller, Philipp Höllthaler, Martina Barends, Marius Döring, Christoph Spahn, Verónica Durán, Bibiana Costa, Jennifer Becker, Mike Heilemann, Ulrich Kalinke, Robert Tampé
Published in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04472-2

Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries.

Author(s): Tim Diederichs; Robert Tampé
Published in: ACS Nano, Issue 1, 2021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c10139

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Author(s): Erich Stefan; Richard Obexer; Susanne Hofmann; Khanh Vu Huu; Yichao Huang; Nina Morgner; Hiroaki Suga; Robert Tampé
Published in: eLife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.67732

Structure and mechanism of immunoreceptors: New horizons in T cell and B cell receptor biology and beyond

Author(s): Christoph Thomas, Robert Tampé
Published in: Current Opinion in Structural Biology, Issue Volume 80, 2023, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2023.102570

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Author(s): Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-05000-9

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

Author(s): Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32841-9