How MHC-I editing complexes shape the hierarchical immune response

Project Information

EditMHC

Grant agreement ID: 789121

DOI

10.3030/789121

Project closed

EC signature date 11 July 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 181 250,00

EU contribution

€ 2 181 250,00

Coordinated by

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming

Author(s): Gaëtan Barbet, Priyanka Nair-Gupta, Michael Schotsaert, Stephen T. Yeung, Julien Moretti, Fabian Seyffer, Giorgi Metreveli, Thomas Gardner, Angela Choi, Domenico Tortorella, Robert Tampé, Kamal M. Khanna, Adolfo García-Sastre, J. Magarian Blander
Published in: Nature Immunology, Issue 22, 2023, Page(s) 497-509, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00903-7

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

Author(s): Lina Sagert, Christian Winter, Ina Ruppert, Maximilian Zehetmaier, Christoph Thomas, Robert Tampé
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85432

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

Author(s): Christian Winter; Alexander Domnick; Darja Cernova; Robert Tampé
Published in: Crossref, Issue 4, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211826

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

Author(s): Samoil Sekulovski, Lukas Susac, Lukas Stelzl, Robert Tampé, Simon Trowitzsch
Published in: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-00992-y

MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity

Author(s): Christoph Thomas, Robert Tampé
Published in: Current Opinion in Immunology, Issue 70, 2021, Page(s) 48-56, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2021.02.004

Dual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation

Author(s): Jamina Brunnberg, Martina Barends, Stefan Frühschulz, Christian Winter, Claire Battin, Ben de Wet, David K. Cole, Peter Steinberger, Robert Tampé
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2321600121

Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase

Author(s): Katharina Sievers, Piotr Neumann, Lukas Sušac, Stefano Da Vela, Melissa Graewert, Simon Trowitzsch, Dmitri Svergun, Robert Tampé, Ralf Ficner
Published in: Structure, Issue 32, 2025, Page(s) 316-327.e5, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2023.12.006

Structural and Mechanistic Principles of ABC Transporters

Author(s): Christoph Thomas, Robert Tampé
Published in: Annual Review of Biochemistry, Issue 89/1, 2020, Page(s) 605-636, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-011520-105201

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Author(s): Jamina Brunnberg; Valentina Herbring; Esteban Günther Castillo; Heike Krüger; Ralph Wieneke; Robert Tampé
Published in: Communications Biology, Issue 3, 2021, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.1038/s42003-021-01890-z

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells

Author(s): Martina Barends, Nicole Koller, Christian Schölz, Robert Tampé
Published in: Proceedings of the National Academy of Sciences (PNAS), 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2219790120

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Author(s): Lukas Susac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O'Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Published in: Cell, Issue Volume 185, Issue 17, 2022, Page(s) 3201-3213.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.010

Molecular basis of MHC I quality control in the peptide loading complex

Author(s): Alexander Domnick, Christian Winter, Lukas Susac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32384-z

Conformation space of a heterodimeric ABC exporter under turnover conditions

Author(s): Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Published in: Nature, Issue 571/7766, 2019, Page(s) 580-583, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1391-0

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

Author(s): Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55326

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Author(s): Erich Stefan, Susanne Hofmann, Robert Tampé
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55943

Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity

Author(s): Simon Trowitzsch, Robert Tampé
Published in: Annual Review of Biophysics, Issue 49/1, 2020, ISSN 1936-122X
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081643

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Author(s): Nicole Koller, Philipp Höllthaler, Martina Barends, Marius Döring, Christoph Spahn, Verónica Durán, Bibiana Costa, Jennifer Becker, Mike Heilemann, Ulrich Kalinke, Robert Tampé
Published in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04472-2

Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries.

Author(s): Tim Diederichs; Robert Tampé
Published in: ACS Nano, Issue 1, 2021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c10139

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Author(s): Erich Stefan; Richard Obexer; Susanne Hofmann; Khanh Vu Huu; Yichao Huang; Nina Morgner; Hiroaki Suga; Robert Tampé
Published in: eLife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.67732

PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

Author(s): Antonius A. de Waard, Tamara Verkerk, Marlieke L. M. Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, Sophie Bliss, Xiangrui Kong, George M. C. Janssen, Arnoud H. de Ru, Frans H. J. Claas, Arend Mulder, Robert Tampé, Peter A. van Veelen, Anne Halenius, Robbert M. Spaapen
Published in: European Journal of Immunology, Issue 51, 2023, Page(s) 734-737, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048599

Structure and mechanism of immunoreceptors: New horizons in T cell and B cell receptor biology and beyond

Author(s): Christoph Thomas, Robert Tampé
Published in: Current Opinion in Structural Biology, Issue Volume 80, 2023, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2023.102570

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation

Author(s): Marius Döring, Hanna Blees, Nicole Koller, Sabine Tischer-Zimmermann, Mathias Müsken, Frederik Henrich, Jennifer Becker, Elena Grabski, Junxi Wang, Hans Janssen, Werner Zuschratter, Jacques Neefjes, Frank Klawonn, Britta Eiz-Vesper, Robert Tampé, Ulrich Kalinke
Published in: Blood Advances, 2019, ISSN 2473-9537
Publisher: Blood Advances
DOI: 10.1182/bloodadvances.201802768

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Author(s): Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-05000-9

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

Author(s): Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32841-9