How MHC-I editing complexes shape the hierarchical immune response

Información del proyecto

EditMHC

Identificador del acuerdo de subvención: 789121

DOI

10.3030/789121

Proyecto cerrado

Fecha de la firma de la CE 11 Julio 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 181 250,00

Aportación de la UE

€ 2 181 250,00

Coordinado por

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (24)

TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming

Autores: Gaëtan Barbet, Priyanka Nair-Gupta, Michael Schotsaert, Stephen T. Yeung, Julien Moretti, Fabian Seyffer, Giorgi Metreveli, Thomas Gardner, Angela Choi, Domenico Tortorella, Robert Tampé, Kamal M. Khanna, Adolfo García-Sastre, J. Magarian Blander
Publicado en: Nature Immunology, Edición 22, 2023, Página(s) 497-509, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-00903-7

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

Autores: Lina Sagert, Christian Winter, Ina Ruppert, Maximilian Zehetmaier, Christoph Thomas, Robert Tampé
Publicado en: eLife, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.85432

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

Autores: Christian Winter; Alexander Domnick; Darja Cernova; Robert Tampé
Publicado en: Crossref, Edición 4, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211826

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

Autores: Samoil Sekulovski, Lukas Susac, Lukas Stelzl, Robert Tampé, Simon Trowitzsch
Publicado en: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-023-00992-y

MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity

Autores: Christoph Thomas, Robert Tampé
Publicado en: Current Opinion in Immunology, Edición 70, 2021, Página(s) 48-56, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2021.02.004

Dual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation

Autores: Jamina Brunnberg, Martina Barends, Stefan Frühschulz, Christian Winter, Claire Battin, Ben de Wet, David K. Cole, Peter Steinberger, Robert Tampé
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2321600121

Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase

Autores: Katharina Sievers, Piotr Neumann, Lukas Sušac, Stefano Da Vela, Melissa Graewert, Simon Trowitzsch, Dmitri Svergun, Robert Tampé, Ralf Ficner
Publicado en: Structure, Edición 32, 2025, Página(s) 316-327.e5, ISSN 0969-2126
Editor: Cell Press
DOI: 10.1016/j.str.2023.12.006

Structural and Mechanistic Principles of ABC Transporters

Autores: Christoph Thomas, Robert Tampé
Publicado en: Annual Review of Biochemistry, Edición 89/1, 2020, Página(s) 605-636, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-011520-105201

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Autores: Jamina Brunnberg; Valentina Herbring; Esteban Günther Castillo; Heike Krüger; Ralph Wieneke; Robert Tampé
Publicado en: Communications Biology, Edición 3, 2021, ISSN 2399-3642
Editor: Communications Biology
DOI: 10.1038/s42003-021-01890-z

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells

Autores: Martina Barends, Nicole Koller, Christian Schölz, Robert Tampé
Publicado en: Proceedings of the National Academy of Sciences (PNAS), 2023, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2219790120

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Autores: Lukas Susac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O'Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Publicado en: Cell, Edición Volume 185, Edición 17, 2022, Página(s) 3201-3213.e19, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2022.07.010

Molecular basis of MHC I quality control in the peptide loading complex

Autores: Alexander Domnick, Christian Winter, Lukas Susac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32384-z

Conformation space of a heterodimeric ABC exporter under turnover conditions

Autores: Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Publicado en: Nature, Edición 571/7766, 2019, Página(s) 580-583, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1391-0

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

Autores: Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.55326

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Autores: Erich Stefan, Susanne Hofmann, Robert Tampé
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.55943

Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity

Autores: Simon Trowitzsch, Robert Tampé
Publicado en: Annual Review of Biophysics, Edición 49/1, 2020, ISSN 1936-122X
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081643

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Autores: Nicole Koller, Philipp Höllthaler, Martina Barends, Marius Döring, Christoph Spahn, Verónica Durán, Bibiana Costa, Jennifer Becker, Mike Heilemann, Ulrich Kalinke, Robert Tampé
Publicado en: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-022-04472-2

Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries.

Autores: Tim Diederichs; Robert Tampé
Publicado en: ACS Nano, Edición 1, 2021, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.0c10139

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Autores: Erich Stefan; Richard Obexer; Susanne Hofmann; Khanh Vu Huu; Yichao Huang; Nina Morgner; Hiroaki Suga; Robert Tampé
Publicado en: eLife, Edición 1, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.67732

PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

Autores: Antonius A. de Waard, Tamara Verkerk, Marlieke L. M. Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, Sophie Bliss, Xiangrui Kong, George M. C. Janssen, Arnoud H. de Ru, Frans H. J. Claas, Arend Mulder, Robert Tampé, Peter A. van Veelen, Anne Halenius, Robbert M. Spaapen
Publicado en: European Journal of Immunology, Edición 51, 2023, Página(s) 734-737, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048599

Structure and mechanism of immunoreceptors: New horizons in T cell and B cell receptor biology and beyond

Autores: Christoph Thomas, Robert Tampé
Publicado en: Current Opinion in Structural Biology, Edición Volume 80, 2023, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2023.102570

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation

Autores: Marius Döring, Hanna Blees, Nicole Koller, Sabine Tischer-Zimmermann, Mathias Müsken, Frederik Henrich, Jennifer Becker, Elena Grabski, Junxi Wang, Hans Janssen, Werner Zuschratter, Jacques Neefjes, Frank Klawonn, Britta Eiz-Vesper, Robert Tampé, Ulrich Kalinke
Publicado en: Blood Advances, 2019, ISSN 2473-9537
Editor: Blood Advances
DOI: 10.1182/bloodadvances.201802768

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Autores: Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Publicado en: Scientific Reports, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-05000-9

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

Autores: Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32841-9