How MHC-I editing complexes shape the hierarchical immune response

Informazioni relative al progetto

EditMHC

ID dell’accordo di sovvenzione: 789121

DOI

10.3030/789121

Progetto chiuso

Data della firma CE 11 Luglio 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 181 250,00

Contributo UE

€ 2 181 250,00

Coordinato da

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (24)

TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming

Autori: Gaëtan Barbet, Priyanka Nair-Gupta, Michael Schotsaert, Stephen T. Yeung, Julien Moretti, Fabian Seyffer, Giorgi Metreveli, Thomas Gardner, Angela Choi, Domenico Tortorella, Robert Tampé, Kamal M. Khanna, Adolfo García-Sastre, J. Magarian Blander
Pubblicato in: Nature Immunology, Numero 22, 2023, Pagina/e 497-509, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-021-00903-7

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

Autori: Lina Sagert, Christian Winter, Ina Ruppert, Maximilian Zehetmaier, Christoph Thomas, Robert Tampé
Pubblicato in: eLife, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.85432

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

Autori: Christian Winter; Alexander Domnick; Darja Cernova; Robert Tampé
Pubblicato in: Crossref, Numero 4, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211826

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

Autori: Samoil Sekulovski, Lukas Susac, Lukas Stelzl, Robert Tampé, Simon Trowitzsch
Pubblicato in: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-023-00992-y

MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Current Opinion in Immunology, Numero 70, 2021, Pagina/e 48-56, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2021.02.004

Dual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation

Autori: Jamina Brunnberg, Martina Barends, Stefan Frühschulz, Christian Winter, Claire Battin, Ben de Wet, David K. Cole, Peter Steinberger, Robert Tampé
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2321600121

Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase

Autori: Katharina Sievers, Piotr Neumann, Lukas Sušac, Stefano Da Vela, Melissa Graewert, Simon Trowitzsch, Dmitri Svergun, Robert Tampé, Ralf Ficner
Pubblicato in: Structure, Numero 32, 2025, Pagina/e 316-327.e5, ISSN 0969-2126
Editore: Cell Press
DOI: 10.1016/j.str.2023.12.006

Structural and Mechanistic Principles of ABC Transporters

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Annual Review of Biochemistry, Numero 89/1, 2020, Pagina/e 605-636, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-011520-105201

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Autori: Jamina Brunnberg; Valentina Herbring; Esteban Günther Castillo; Heike Krüger; Ralph Wieneke; Robert Tampé
Pubblicato in: Communications Biology, Numero 3, 2021, ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-021-01890-z

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells

Autori: Martina Barends, Nicole Koller, Christian Schölz, Robert Tampé
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2219790120

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Autori: Lukas Susac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O'Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Pubblicato in: Cell, Numero Volume 185, Numero 17, 2022, Pagina/e 3201-3213.e19, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2022.07.010

Molecular basis of MHC I quality control in the peptide loading complex

Autori: Alexander Domnick, Christian Winter, Lukas Susac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32384-z

Conformation space of a heterodimeric ABC exporter under turnover conditions

Autori: Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Pubblicato in: Nature, Numero 571/7766, 2019, Pagina/e 580-583, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1391-0

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

Autori: Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55326

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Autori: Erich Stefan, Susanne Hofmann, Robert Tampé
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55943

Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity

Autori: Simon Trowitzsch, Robert Tampé
Pubblicato in: Annual Review of Biophysics, Numero 49/1, 2020, ISSN 1936-122X
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081643

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Autori: Nicole Koller, Philipp Höllthaler, Martina Barends, Marius Döring, Christoph Spahn, Verónica Durán, Bibiana Costa, Jennifer Becker, Mike Heilemann, Ulrich Kalinke, Robert Tampé
Pubblicato in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04472-2

Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries.

Autori: Tim Diederichs; Robert Tampé
Pubblicato in: ACS Nano, Numero 1, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c10139

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Autori: Erich Stefan; Richard Obexer; Susanne Hofmann; Khanh Vu Huu; Yichao Huang; Nina Morgner; Hiroaki Suga; Robert Tampé
Pubblicato in: eLife, Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.67732

PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

Autori: Antonius A. de Waard, Tamara Verkerk, Marlieke L. M. Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, Sophie Bliss, Xiangrui Kong, George M. C. Janssen, Arnoud H. de Ru, Frans H. J. Claas, Arend Mulder, Robert Tampé, Peter A. van Veelen, Anne Halenius, Robbert M. Spaapen
Pubblicato in: European Journal of Immunology, Numero 51, 2023, Pagina/e 734-737, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048599

Structure and mechanism of immunoreceptors: New horizons in T cell and B cell receptor biology and beyond

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Current Opinion in Structural Biology, Numero Volume 80, 2023, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2023.102570

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation

Autori: Marius Döring, Hanna Blees, Nicole Koller, Sabine Tischer-Zimmermann, Mathias Müsken, Frederik Henrich, Jennifer Becker, Elena Grabski, Junxi Wang, Hans Janssen, Werner Zuschratter, Jacques Neefjes, Frank Klawonn, Britta Eiz-Vesper, Robert Tampé, Ulrich Kalinke
Pubblicato in: Blood Advances, 2019, ISSN 2473-9537
Editore: Blood Advances
DOI: 10.1182/bloodadvances.201802768

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Autori: Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Pubblicato in: Scientific Reports, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-05000-9

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

Autori: Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32841-9