How MHC-I editing complexes shape the hierarchical immune response

Pubblicazioni

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

Autori: Christian Winter; Alexander Domnick; Darja Cernova; Robert Tampé
Pubblicato in: Crossref, Numero 4, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211826

MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Current Opinion in Immunology, Numero 70, 2021, Pagina/e 48-56, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2021.02.004

Structural and Mechanistic Principles of ABC Transporters

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Annual Review of Biochemistry, Numero 89/1, 2020, Pagina/e 605-636, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-011520-105201

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Autori: Jamina Brunnberg; Valentina Herbring; Esteban Günther Castillo; Heike Krüger; Ralph Wieneke; Robert Tampé
Pubblicato in: Communications Biology, Numero 3, 2021, ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-021-01890-z

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Autori: Lukas Susac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O'Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Pubblicato in: Cell, Numero Volume 185, Numero 17, 2022, Pagina/e 3201-3213.e19, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2022.07.010

Molecular basis of MHC I quality control in the peptide loading complex

Autori: Alexander Domnick, Christian Winter, Lukas Susac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32384-z

Conformation space of a heterodimeric ABC exporter under turnover conditions

Autori: Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Pubblicato in: Nature, Numero 571/7766, 2019, Pagina/e 580-583, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1391-0

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

Autori: Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55326

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Autori: Erich Stefan, Susanne Hofmann, Robert Tampé
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55943

Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity

Autori: Simon Trowitzsch, Robert Tampé
Pubblicato in: Annual Review of Biophysics, Numero 49/1, 2020, ISSN 1936-122X
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081643

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Autori: Nicole Koller, Philipp Höllthaler, Martina Barends, Marius Döring, Christoph Spahn, Verónica Durán, Bibiana Costa, Jennifer Becker, Mike Heilemann, Ulrich Kalinke, Robert Tampé
Pubblicato in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04472-2

Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries.

Autori: Tim Diederichs; Robert Tampé
Pubblicato in: ACS Nano, Numero 1, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c10139

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Autori: Erich Stefan; Richard Obexer; Susanne Hofmann; Khanh Vu Huu; Yichao Huang; Nina Morgner; Hiroaki Suga; Robert Tampé
Pubblicato in: eLife, Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.67732

Structure and mechanism of immunoreceptors: New horizons in T cell and B cell receptor biology and beyond

Autori: Christoph Thomas, Robert Tampé
Pubblicato in: Current Opinion in Structural Biology, Numero Volume 80, 2023, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2023.102570

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Autori: Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Pubblicato in: Scientific Reports, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-05000-9

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

Autori: Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32841-9

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