Stepping Up mRNA Mutanome Immunotherapy

Project Information

SUMMIT

Grant agreement ID: 789256

DOI 10.3030/789256

Project closed

EC signature date 11 July 2018

Start date 1 August 2018

End date 31 July 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 482 500,00

EU contribution € 2 482 500,00

Coordinated by

TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GEMEINNUTZIGE GMBH
Germany

Publications

Peer reviewed articles (6)

Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens

Author(s): David Weber, Jonas Ibn-Salem, Patrick Sorn, Martin Suchan, Christoph Holtsträter, Urs Lahrmann, Isabel Vogler, Kathrin Schmoldt, Franziska Lang, Barbara Schrörs, Martin Löwer and Ugur Sahin
Published in: Nature Biotechnology, Issue 04-04-2022, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01247-9

Multiple instance learning to predict immune checkpoint blockade efficacy usingneoantigen candidates

Author(s): Franziska Lang, Patrick Sorn, Barbara Schrörs, David Weber, Stefan Kramer, Ugur Sahin, Martin Löwer
Published in: iScience, Issue monthly, 2023, ISSN 2589-0042
Publisher: iScience
DOI: 10.1016/j.isci.2023.108014

NeoFox: annotating neoantigen candidates with neoantigen features

Author(s): Franziska Lang, Pablo Riesgo Ferreiro, Martin Löwer, Ugur Sahin, Barbara Schrörs
Published in: Bioinformatics, 2021, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btab344

Integrative analysis of structural variations using short-reads and linked-reads yields highly specific and sensitive predictions

Author(s): Riccha Sethi, Julia Becker, Jos de Graaf, Martin Löwer, Martin Suchan, Ugur Sahin, David Weber
Published in: PLOS Computational Biology, Issue 16/11, 2020, Page(s) e1008397, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1008397

Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model

Author(s): Barbara Schrörs, Sebastian Boegel, Christian Albrecht, Thomas Bukur, Valesca Bukur, Christoph Holtsträter, Christoph Ritzel, Katja Manninen, Arbel D. Tadmor, Mathias Vormehr, Ugur Sahin, Martin Löwer
Published in: Frontiers in Oncology, Issue 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01195

Identification of neoantigens for individualized therapeutic cancer vaccines

Author(s): Franziska Lang, Barbara Schrörs, Martin Löwer, Özlem Türeci & Ugur Sahin
Published in: Nature Reviews Drug Discovery, Issue 01/02/2022, 2022, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-021-00387-y

Other (1)

Prediction of tumor-specific splicing from somatic mutations as a source of neoantigen candidates

Author(s): Franziska Lang, Patrick Sorn, Martin Suchan, Alina Henrich, Christian Albrecht, Nina Koehl, Aline Beicht, Pablo Riesgo-Ferreiro, Christoph Holtsträter, Barbara Schrörs, David Weber, Martin Löwer, Ugur Sahin, Jonas Ibn-Salem
Published in: biorxiv The preprint server for biology, 2023
Publisher: biorxiv
DOI: 10.1101/2023.06.27.546494