Structural and functional characterization of the ICOS/ICOSL immune complex

Informations projet

SI

N° de convention de subvention: 790012

DOI 10.3030/790012

Projet clôturé

Date de signature de la CE 15 Février 2018

Date de début 1 Août 2018

Date de fin 31 Decembre 2021

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 224 683,20

Contribution de l’UE € 224 683,20

Coordonné par

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain

Publications

Peer reviewed articles (6)

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Auteurs: Moustafa T Mabrouk, Kevin Chiem, Edurne Rujas, Wei-Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H Nissly, Victoria S Cavener, Nina R Boyle, Ty A Sornberger, Suresh V Kuchipudi, Joaquin Ortega, Jean-Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell
Publié dans: Science Advances, 2021, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abj1476

Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity

Auteurs: Edurne Rujas, Hong Cui, Jonathan Burnie, Clare Burn Aschner, Tiantian Zhao, Sara Insausti, Krithika Muthuraman, Anthony Semesi, Jasper Ophel, Jose L Nieva, Michael S Seaman, Christina Guzzo, Bebhinn Treanor, Jean-Philippe Julien
Publié dans: Proc Natl Acad Sci U S A, 2022, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2112887119

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Auteurs: Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, Jo
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23825-2

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Auteurs: Michael G Sugiyama, Haotian Cui, Dar'ya S Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B McPhee, Russell D Viirre, Andrew Haller, Roberto J Botelho, Raffi Karshafian, Sarah A Sabatinos, Gregory D Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S MacKinnon, Bo Wang, Costin N Antonescu
Publié dans: Scientific Reports, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-02432-7

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Auteurs: Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B.Zwick, Jose M.M. Caaveiro, José L. Nieva
Publié dans: iScience, 2021, ISSN 2589-0042
Éditeur: Elsevier Inc.
DOI: 10.1016/j.isci.2021.102987

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Auteurs: Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18828-4