Structural and functional characterization of the ICOS/ICOSL immune complex

Informazioni relative al progetto

SI

ID dell’accordo di sovvenzione: 790012

DOI 10.3030/790012

Progetto chiuso

Data della firma CE 15 Febbraio 2018

Data di avvio 1 Agosto 2018

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 224 683,20

Contributo UE € 224 683,20

Coordinato da

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain

Pubblicazioni

Peer reviewed articles (6)

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Autori: Moustafa T Mabrouk, Kevin Chiem, Edurne Rujas, Wei-Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H Nissly, Victoria S Cavener, Nina R Boyle, Ty A Sornberger, Suresh V Kuchipudi, Joaquin Ortega, Jean-Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell
Pubblicato in: Science Advances, 2021, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abj1476

Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity

Autori: Edurne Rujas, Hong Cui, Jonathan Burnie, Clare Burn Aschner, Tiantian Zhao, Sara Insausti, Krithika Muthuraman, Anthony Semesi, Jasper Ophel, Jose L Nieva, Michael S Seaman, Christina Guzzo, Bebhinn Treanor, Jean-Philippe Julien
Pubblicato in: Proc Natl Acad Sci U S A, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2112887119

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Autori: Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, Jo
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23825-2

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Autori: Michael G Sugiyama, Haotian Cui, Dar'ya S Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B McPhee, Russell D Viirre, Andrew Haller, Roberto J Botelho, Raffi Karshafian, Sarah A Sabatinos, Gregory D Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S MacKinnon, Bo Wang, Costin N Antonescu
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-02432-7

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Autori: Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B.Zwick, Jose M.M. Caaveiro, José L. Nieva
Pubblicato in: iScience, 2021, ISSN 2589-0042
Editore: Elsevier Inc.
DOI: 10.1016/j.isci.2021.102987

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Autori: Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18828-4