iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION

Informations projet

iFermenter

N° de convention de subvention: 790507

DOI

10.3030/790507

Projet clôturé

Date de signature de la CE 24 Avril 2018

Date de début 1 Mai 2018

Date de fin 31 Juillet 2022

Financé au titre de

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Coût total

€ 5 320 895,00

Contribution de l’UE

€ 3 997 825,00

Coordonné par

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (2)

Movie - demonstration

Movie demonstration

External website of iFermenter

External website of iFermenter open to the public, but also has secured login intranet pages to share secure internal information

Other (4)

Workshops RRI multi-actor dialogs

Workshops RRI multi-actor dialogs: White biotechnology and circular economy

Metabolic model, describing different physiological states of the cell factories

Metabolic model describing different physiological states of the cell factories

Genome network reduced dynamic mode
Process level reduced dynamic model

Documents, reports (3)

Initial Environmental impact assessment

Environmental impact assessment of the new strain, successfully demonstrating 20% reduction of CO2 in milliscales laboratory conditions

Developed (reduced) 3 models for the levels

Developed reduced 3 models for the levels genome metabolic and process Model predictions have satisfactory error margins 25 when compared to data D32 D34 D36

Successful demonstration of 20% reduction in CO2 footprint from the upscaled industrial process, by an LCA report

Successful demonstration of 20 reduction in CO2 footprint from the upscaled industrial process by an LCA report Environmental and demonstrating potential costs of upscaling the process O4b

Publications

Peer reviewed articles (18)

Recombinant production of the lantibiotic nisin using <i>Corynebacterium glutamicum</i> in a two-step process

Auteurs: Dominik Weixler; Max Berghoff; Kirill V. Ovchinnikov; Sebastian Reich; Oliver Goldbeck; Gerd M. Seibold; Christoph Wittmann; Nadav S. Bar; Bernhard J. Eikmanns; Dzung B. Diep; Christian U. Riedel
Publié dans: Microbial Cell Factories, Numéro 1, 2022, ISSN 1475-2859
Éditeur: BioMed Central
DOI: 10.1186/s12934-022-01739-y

Sensor fusion based on Extended and Unscented Kalman Filter for bioprocess monitoring

Auteurs: Andrea Tuveri; Fernando Pérez-García; Pedro A. Lira-Parada; Lars Imsland; Nadav Bar
Publié dans: Journal of Process Control, Numéro 2, 2021, ISSN 0959-1524
Éditeur: Butterworth Scientific Ltd.
DOI: 10.1016/j.jprocont.2021.09.005

Waste biorefinery towards a sustainable biotechnological production of pediocin: Synergy between process simulation and environmental assessment

Auteurs: Ana Arias, Daniel Barreiro, Gumersindo Feijoo, Maria Teresa Moreira
Publié dans: Environmental Technology & Innovation, Numéro 26, 2022, ISSN 2352-1864
Éditeur: Elsevier BV
DOI: 10.1016/j.eti.2022.102306

Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum

Auteurs: Oliver Goldbeck, Dominique N. Desef, Kirill V. Ovchinnikov, Fernando Perez-Garcia, Jens Christmann, Peter Sinner, Peter Crauwels, Dominik Weixler, Peng Cao, Judith Becker, Michael Kohlstedt, Julian Kager, Bernhard J. Eikmanns, Gerd M. Seibold, Christoph Herwig, Christoph Wittmann, Nadav S. Bar, Dzung B. Diep, Christian U. Riedel
Publié dans: Metabolic Engineering, 2021, ISSN 1096-7176
Éditeur: Academic Press
DOI: 10.1016/j.ymben.2021.09.002

Inventory review and environmental evaluation of first- and second-generation sugars through life cycle assessment.

Auteurs: Sara Bello; Iana Salim; Gumersindo Feijoo; Maria Teresa Moreira
Publié dans: Environmental Science and Pollution Research, Numéro 3, 2021, ISSN 0944-1344
Éditeur: Springer Verlag
DOI: 10.1007/s11356-021-12405-y

Dynamic Co-Cultivation Process of Corynebacterium glutamicum Strains for the Fermentative Production of Riboflavin

Auteurs: Fernando Pérez-García, Arthur Burgardt, Dina R. Kallman, Volker F. Wendisch, Nadav Bar
Publié dans: Fermentation, Numéro 7/1, 2021, Page(s) 11, ISSN 2311-5637
Éditeur: MDPI
DOI: 10.3390/fermentation7010011

In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium

Auteurs: Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel
Publié dans: Microorganisms, Numéro 9/3, 2021, Page(s) 646, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms9030646

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Auteurs: Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann
Publié dans: Essays in Biochemistry, 2021, ISSN 0071-1365
Éditeur: Portland Press, Ltd.
DOI: 10.1042/ebc20200134

The use of maize stover and sugar beet pulp as feedstocks in industrial fermentation plants – An economic and environmental perspective

Auteurs: Iana Câmara-Salim; Pablo Conde; Gumersindo Feijoo; Maria Teresa Moreira
Publié dans: Cleaner Environmental Systems, Numéro 3, 2021, ISSN 2666-7894
Éditeur: Elsevier
DOI: 10.1016/j.cesys.2020.100005

Technological feasibility and environmental assessment of polylactic acid-nisin-based active packaging.

Auteurs: Arias, A., Feijoo, G. & Moreira, M.T.
Publié dans: Sustainable Materials and Technologies, 2022, ISSN 2214-9937
Éditeur: Elsevier
DOI: 10.1016/j.susmat.2022.e00460

Linking process and metabolic modelling for the estimation of carbon flux distribution in Corynebacterium glutamicum growth in spent sulfite liquor

Auteurs: Pedro A.Lira-Parada, PeterSinner, MichaelKohlstedt, JulianKager, ChristophWittmann, ChristophHerwig, NadavBar
Publié dans: IFAC-PapersOnLine, 2022, ISSN 2405-8963
Éditeur: Elsevier
DOI: 10.1016/j.ifacol.2022.07.449

BECCS based on bioethanol from wood residues: Potential towards a carbon-negative transport and side-effects

Auteurs: Sara Bello, Ángel Galán-Martín, Gumersindo Feijoo, Maria Teresa Moreira, Gonzalo Guillén-Gosálbez
Publié dans: Applied Energy, Numéro 279, 2020, Page(s) 115884, ISSN 0306-2619
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apenergy.2020.115884

Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty

Auteurs: Peter Sinner, Marlene Stiegler, Christoph Herwig, Julian Kager
Publié dans: Bioresource Technology, Numéro 321, 2021, Page(s) 124395, ISSN 0960-8524
Éditeur: Elsevier BV
DOI: 10.1016/j.biortech.2020.124395

The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution

Auteurs: Ingvild S. Reinseth, Kirill V. Ovchinnikov, Hanne H. Tønnesen, Harald Carlsen, Dzung B. Diep
Publié dans: Probiotics and Antimicrobial Proteins, 2019, ISSN 1867-1306
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s12602-019-09618-6

Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste

Auteurs: Peter Sinner, Julian Kager, Sven Daume, Christoph Herwig
Publié dans: IFAC-PapersOnLine, 2019, ISSN 2405-8963
Éditeur: Elsevier

The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations

Auteurs: Fabian Stefan Franz Hartmann, Lina Clermont, Quach Ngoc Tung, Haike Antelmann, Gerd Michael Seibold
Publié dans: Antioxidants, Numéro 9/10, 2020, Page(s) 969, ISSN 2076-3921
Éditeur: MDPI
DOI: 10.3390/antiox9100969

Establishing the multi-criteria roadmap and metrics for the evaluation of active films for food packaging

Auteurs: Arias, A., Feijoo, G., & Moreira, M. T.
Publié dans: Current Research in Green and Sustainable Chemistry, Numéro 4, 2021, ISSN 2666-0865
Éditeur: Elsevier
DOI: 10.1016/j.crgsc.2021.100160

Process and environmental simulation in the validation of the biotechnological production of nisin from waste

Auteurs: Arias, A., Feijoo, G., & Moreira, M. T.
Publié dans: Biochemical Engineering Journal, Numéro 174, 2021, ISSN 1369-703X
Éditeur: Elsevier BV
DOI: 10.1016/j.bej.2021.108105

Book chapters (2)

Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess

Auteurs: Peter Sinner, Christoph Herwig, Julian Kager
Publié dans: 30th European Symposium on Computer Aided Process Engineering, Numéro 48, 2020, Page(s) 1603-1608, ISBN 9780128233771
Éditeur: Elsevier
DOI: 10.1016/b978-0-12-823377-1.50268-8

Usage of Digital Twins Along a Typical Process Development Cycle

Auteurs: Peter Sinner, Sven Daume, Christoph Herwig, Julian Kager
Publié dans: Digital Twins - Tools and Concepts for Smart Biomanufacturing, Numéro 176, 2021, Page(s) 71-96, ISBN 978-3-030-71659-2
Éditeur: Springer International Publishing
DOI: 10.1007/10_2020_149