Objectif A primary crop in Ireland, wheat is the most important cereal within the EU. Zymoseptoria tritici, the causal agent of septoria tritici blotch (STB) disease, continuously threatens Europe’s wheat crop causing loses of up to 50%, if left untreated. The absence of commercial varieties with adequate STB resistance means the sector is wholly dependent on fungicides to offset STB, with control costs >€1bn pa. This chemical dependency has driven the appearance of fungicide resistant strains of Z. tritici. In addition, EU legislation has removed several fungicides due to environmental concerns. In short, the European wheat sector has an unsustainable future unless greater effort is made to identify durable sources of resistance to STB. This is where new breeding methodologies (e.g. genomic selection, GS) can assist traditional breeding initiatives. GS is a form of marker assisted selection that simultaneously estimates all loci, haplotype or marker effects across the entire genome to calculate Genomic Estimated Breeding Values (GEBVs). GEBVs are then used to select individuals of interest for advancement in the breeding cycle. This proposal will apply a GS strategy to a unique population (>600) of wheat lines (DiverseMAGIC, NIAB), that are firstly phenotyped in the presence of natural field-borne STB inoculum. Taking advantage of NIAB resources (35K SNP data, exome capture, genetic maps), this action will combine genotype and field phenotype data so that relevant QTL associated with contrasting STB resistant profiles can be identified. In parallel, an in-house gene editing system will be employed to edit several gene sequences that have demonstrated to be STB responsive based on previously accumulated RNAseq data. Multi-disciplinary in nature, we envisage this proposal (plus secondment) will identify novel sources of resistance to STB disease that thereafter will be integrated into European wheat breeding programmes through existing networks with this project’s partners. Champ scientifique medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesgeneticsgenomesagricultural sciencesagriculture, forestry, and fisheriesagriculturegrains and oilseedscereals Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2017 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2017 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY Contribution nette de l'UE € 175 866,00 Adresse Oak Park R93 Carlow Irlande Voir sur la carte Région Ireland Southern South-East Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 175 866,00