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Structural basis for the therapeutic efficiency of optimal-affinity T cell receptors

Project description

A 3D snapshot of antigen recognition could pave the way to enhanced immunotherapy

Cancer immunotherapy is gaining a lot of interest for its potential to boost a person's own immune system to attack tumours, but treatment efficacy and patient response have so far been unpredictable. Among the most important cells in the immune system are the T-cells that mediate adaptive immunity via their T-cell receptors (TCRs). TCRs recognise invaders from small molecules (peptides) presented to them by so-called antigen-presenting cells via major histocompatibility complex (MHC) proteins. This process is extremely specific in vivo and harnessing this specificity could provide a breakthrough in immunotherapy. The EU-funded TCRabX project is using high-tech methods to study the detailed 3D structures of TCRs bound to MHC proteins to identify the TCR contact regions.

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 264 110,40
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MONASH UNIVERSITY
Australia
Net EU contribution
€ 0,00
Other funding
€ 178 380,00