Project description
A 3D snapshot of antigen recognition could pave the way to enhanced immunotherapy
Cancer immunotherapy is gaining a lot of interest for its potential to boost a person's own immune system to attack tumours, but treatment efficacy and patient response have so far been unpredictable. Among the most important cells in the immune system are the T-cells that mediate adaptive immunity via their T-cell receptors (TCRs). TCRs recognise invaders from small molecules (peptides) presented to them by so-called antigen-presenting cells via major histocompatibility complex (MHC) proteins. This process is extremely specific in vivo and harnessing this specificity could provide a breakthrough in immunotherapy. The EU-funded TCRabX project is using high-tech methods to study the detailed 3D structures of TCRs bound to MHC proteins to identify the TCR contact regions.
Fields of science
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesclinical medicinesurgery
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicineimmunologyimmunotherapy
- natural sciencesbiological sciencesmolecular biologystructural biology
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
10117 Berlin
Germany
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Partners (1)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3800 Victoria
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