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Structural basis for the therapeutic efficiency of optimal-affinity T cell receptors

Project description

A 3D snapshot of antigen recognition could pave the way to enhanced immunotherapy

Cancer immunotherapy is gaining a lot of interest for its potential to boost a person's own immune system to attack tumours, but treatment efficacy and patient response have so far been unpredictable. Among the most important cells in the immune system are the T-cells that mediate adaptive immunity via their T-cell receptors (TCRs). TCRs recognise invaders from small molecules (peptides) presented to them by so-called antigen-presenting cells via major histocompatibility complex (MHC) proteins. This process is extremely specific in vivo and harnessing this specificity could provide a breakthrough in immunotherapy. The EU-funded TCRabX project is using high-tech methods to study the detailed 3D structures of TCRs bound to MHC proteins to identify the TCR contact regions.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /natural sciences/earth and related environmental sciences/geology/mineralogy/crystallography
  • /natural sciences/mathematics/pure mathematics/topology
  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/biological sciences/molecular biology/structural biology
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-IF-2017
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 264 110,40

Partners (1)

MONASH UNIVERSITY
Australia
Address
Wellington Road
3800 Victoria
Activity type
Higher or Secondary Education Establishments