Objective
Colorectal cancer (CRC) is the most common neoplastic pathology in the developed world. It is the second in frequency in men after prostate cancer and the second in women after breast cancer. Survival at five years, if all stages are taken into account, is approximately 50%. That represents a mortality of 20 cases per 100,000 inhabitants per year. The five-year survival of early stages, a situation almost equivalent to cure, is approximately 90%, whereas in advanced or metastatic stages it is less than 10%. Therefore, early diagnosis plays a central role in the improvement of survival rates.
The main goal of this project is to find new ways to detect the cancer in the very early stages. To do so, the sample collection must be as simple, economic and convenient as possible. Only in this manner, regular screening approaching 100% of adult population will take place. The approach we propose is the identification and validation of new biomarkers in urine that can be used to diagnose colorectal cancer (CRC) at a very early stage.
The central hypothesis is that CRC associated metabolites in the urine of patients can be segregated from patients with polyps (some of them precursors of CRC) and control subjects, and that their levels are correlated with clinical diagnostics of a CRC stage. Urine is an easy collectible biofluid for its non-invasiveness, and it can provide early detection of cancers. New sample measurement protocols and techniques are enhancing both selectivity and sensitivity by orders of magnitude, such as SPME and Twisters or GC/LC-MS systems (GCxGX/LC-QTOF-MS). The more sensitivity and selectivity, the more confindent diagnosis could be made at earlier stages of the cancerous process leading to a better survivability rate.
Moreover, our proposal includes a multi-cohort, multi-laboratory validation of the findings, therefore ensuring that any discovery can readily be applied to any population and instrumentation around de world.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- social sciences sociology demography mortality
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43003 Tarragona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.