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Evolvable platform for programmable nanoparticle-based cancer therapies

Deliverables

Evolutionary model definition and specifications

A report containing a description of the eCS approach, definition of the meta model and specification for the implementation of the meta model.

Report of the kick-off meeting

Report of the decisions from the kick-off meeting, its agenda and list of participants.

Technical/scientific review meeting documents for RP1

Draft agenda, presentations and other review meeting documents before the review meeting.

Dissemination and Exploitation Plan at the end of the first Reporting Period (RP1)

Plan for dissemination and exploitation activities that will be updated for the subsequent Reporting Periods.

eCS vascular and CSC strategies

Evolved mechanisms of NP circulation and NP-CSC interactions. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.

Web site, logo and other mass media presence

A report on launched website, logo, blog, social media channels, high-quality video presentation of the project and brochure/flyer.

eCS endothelial and tumour strategies

Evolved mechanisms of NP endothelial and tumour penetration. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.

First in vitro validation

Report on validation of devices 1&4. Validation will be performed by injecting previously prepared and synthesized NPs (Task 3.2) into devices 1&4 (Task 3.1).

Workshop organization

Organized International Workshop: “Evolving nano-treatments of cancer”.

Data management plan

Delivered a first version of Data Management Plan (DMP)

Initial eCS implementation and testing

eCS platform is implemented, (Task 1.2), tested (Task 1.3), documented and uploaded to the public repository.

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Publications

In silico modelling of cancer nanomedicine, across scales and transport barriers.

Author(s): Namid R. Stillman, Marina Kovacevic, Igor Balaz & Sabine Hauert
Published in: npj Computational Materials, Issue 6, 92, 2020, ISSN 2057-3960
DOI: 10.1038/s41524-020-00366-8

Harnessing adaptive novelty for automated generation of cancer treatments

Author(s): Igor Balaz, Tara Petrić, Marina Kovacevic, Michail-Antisthenis Tsompanas, Namid Stillman
Published in: Biosystems, 2020, Page(s) 104290, ISSN 0303-2647
DOI: 10.1016/j.biosystems.2020.104290

Toward Engineering Biosystems With Emergent Collective Functions

Author(s): Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T.-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00705

Towards an evolvable cancer treatment simulator

Author(s): Richard J. Preen, Larry Bull, Andrew Adamatzky
Published in: Biosystems, Issue 182, 2019, Page(s) 1-7, ISSN 0303-2647
DOI: 10.1016/j.biosystems.2019.05.005

Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells

Author(s): Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. Díaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc Martínez-Trucharte, Patricia González, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan Sayós, Ibane Abasolo, Simo Schwartz
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 24, 2020, Page(s) 102106, ISSN 1549-9634
DOI: 10.1016/j.nano.2019.102106

Novelty search employed into the development of cancer treatment simulations

Author(s): Michail-Antisthenis Tsompanas, Larry Bull, Andrew Adamatzky, Igor Balaz
Published in: Informatics in Medicine Unlocked, 2020, Page(s) 100347, ISSN 2352-9148
DOI: 10.1016/j.imu.2020.100347

Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells

Author(s): Gener, Rafael, Seras-Franzoso, Perez, Pindado, Casas, Arango, Fernández, Díaz-Riascos, Abasolo, Schwartz
Published in: Cancers, Issue 11/8, 2019, Page(s) 1058, ISSN 2072-6694
DOI: 10.3390/cancers11081058