Risultati finali
Final report on performed molecular dynamics simulations developed XAI model and results of XAI predictions
Evolutionary model definition and specificationsA report containing a description of the eCS approach, definition of the meta model and specification for the implementation of the meta model.
Report of the kick-off meetingReport of the decisions from the kick-off meeting, its agenda and list of participants.
Technical/scientific review meeting documents for RP2Draft agenda presentations and other review meeting documents before the review meeting
Technical/scientific review meeting documents for RP1Draft agenda, presentations and other review meeting documents before the review meeting.
In vivo validationFinal report on the results of in vivo validation results of NP biodistribution pharmacokinetics toxicity and efficacy in human cancer xenograft animal models Validation will be performed by injecting previously prepared and synthesized NPs Task 32 into athymic mice
Dissemination and Exploitation Plan at the end of the first Reporting Period (RP1)Plan for dissemination and exploitation activities that will be updated for the subsequent Reporting Periods.
eCS vascular and CSC strategiesEvolved mechanisms of NP circulation and NP-CSC interactions. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.
Web site, logo and other mass media presenceA report on launched website, logo, blog, social media channels, high-quality video presentation of the project and brochure/flyer.
Mid-term MD simulations and XAI toy modelReport on performed molecular dynamics simulations and developed XAI toy model based on data obtained from molecular dynamics simulations
eCS anti-cancer strategiesEvolved complete DDS strategies that include NP circulation transvascular NP translocation tumour penetration and NPCSC interaction The report will comprise description of experimental settings Task 21 results of in silico experiments Task 22 and analysis and scoring of evolved strategies Task 23 Report will provide specifications and criteria for evaluating and scoring of evolved strategies
Final report on communication and dissemination activitiesFinal in vitro validation
Report on the results of in vitro validation results of NP extravasations tumour penetration cellular uptake viability and pharmacological effect of the evolved nanoparticle strategies Validation will be performed by injecting previously prepared and synthesized NPs Task 32 into all prepared microfluidic devices Task 31
eCS endothelial and tumour strategiesEvolved mechanisms of NP endothelial and tumour penetration. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.
First in vitro validationReport on validation of devices 1&4. Validation will be performed by injecting previously prepared and synthesized NPs (Task 3.2) into devices 1&4 (Task 3.1).
Improved eCS platform tested documented and uploaded to the public repository Documentation will include a report on implemented improvements Task 12 and their operational testing results Task 13
Final eCS implementation and testingFinal version of the eCS platform tested documented and uploaded to the public repository Documentation will include a report on latest improvements Task 12 and their operational testing results Task 13
Initial eCS implementation and testingeCS platform is implemented, (Task 1.2), tested (Task 1.3), documented and uploaded to the public repository.
Organized International Workshop: “Evolving nano-treatments of cancer”.
Delivered a first version of Data Management Plan (DMP)
Pubblicazioni
Autori:
Igor Balaz, Sabine Hauert, Andrew Adamatzky
Pubblicato in:
Biosystems, Numero 204, 2021, ISSN 0303-2647
Editore:
Elsevier BV
DOI:
10.1016/j.biosystems.2021.104385
Autori:
Michail-AntisthenisTsompanas, LarryBull, AndrewAdamatzky, IgorBalaz
Pubblicato in:
Computer Methods and Programs in Biomedicine, Numero 200, 2021, ISSN 0169-2607
Editore:
Elsevier BV
DOI:
10.1016/j.cmpb.2020.105886
Autori:
Namid R. Stillman, Marina Kovacevic, Igor Balaz & Sabine Hauert
Pubblicato in:
npj Computational Materials, Numero 6, 92, 2020, ISSN 2057-3960
Editore:
Nature Publishing Group
DOI:
10.1038/s41524-020-00366-8
Autori:
Namid R. Stillman; Igor Balaz; Michail-Antisthenis I. Tsompanas; Marina Kovacevic; Sepinoud Azimi; Sebastien Lafond; Andrew Adamatzky; Sabine Hauert
Pubblicato in:
npj Computational Materials, Vol 7, Iss 1, Pp 1-12 (2021), Numero 2, 2021, Pagina/e 1-12, ISSN 2057-3960
Editore:
Springer Nature
DOI:
10.1038/s41524-021-00614-5
Autori:
Petra Gener , Patricia Gonzalez Callejo, Joaquín Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo & Simo Schwartz
Pubblicato in:
Nanomedicine, Numero 15, 2020, Pagina/e 2785-2800, ISSN 1743-5889
Editore:
Future Medicine Ltd.
DOI:
10.2217/nnm-2020-0099
Autori:
Scott C McCormick, Namid Stillman, Matthew Hockley, Adam W Perriman, Sabine Hauert
Pubblicato in:
International Journal of Nanomedicine, Numero 16, 2021, Pagina/e 2585–2595, ISSN 1178-2013
Editore:
DovePress
DOI:
10.2147/ijn.s292131
Autori:
Michail-Antisthenis I. Tsompanas; Larry Bull; Andrew Adamatzky; Igor Balaz
Pubblicato in:
Biocybernetics and Biomedical Engineering, Numero 6, 2021, Pagina/e 352-361, ISSN 0208-5216
Editore:
Polish Scientific Publishers PWN
DOI:
10.1016/j.bbe.2021.02.002
Autori:
Igor Balaz, Tara Petrić, Marina Kovacevic, Michail-Antisthenis Tsompanas, Namid Stillman
Pubblicato in:
Biosystems, 2020, Pagina/e 104290, ISSN 0303-2647
Editore:
Elsevier BV
DOI:
10.1016/j.biosystems.2020.104290
Autori:
Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T.-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward
Pubblicato in:
Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore:
Frontiers
DOI:
10.3389/fbioe.2020.00705
Autori:
Sergio Dávila, Jean Cacheux, Isabel Rodríguez
Pubblicato in:
ACS Omega, Numero 6, 2021, Pagina/e 25109–25115, ISSN 2470-1343
Editore:
ACSPublications
DOI:
10.1021/acsomega.1c00735
Autori:
Richard J. Preen, Larry Bull, Andrew Adamatzky
Pubblicato in:
Biosystems, Numero 182, 2019, Pagina/e 1-7, ISSN 0303-2647
Editore:
Elsevier BV
DOI:
10.1016/j.biosystems.2019.05.005
Autori:
Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. Díaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc Martínez-Trucharte, Patricia González, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan Sayós, Ibane Abasolo, Simo Schwartz
Pubblicato in:
Nanomedicine: Nanotechnology, Biology and Medicine, Numero 24, 2020, Pagina/e 102106, ISSN 1549-9634
Editore:
Elsevier BV
DOI:
10.1016/j.nano.2019.102106
Autori:
Michail-Antisthenis Tsompanas, Larry Bull, Andrew Adamatzky, Igor Balaz
Pubblicato in:
Informatics in Medicine Unlocked, 2020, Pagina/e 100347, ISSN 2352-9148
Editore:
Elsevier
DOI:
10.1016/j.imu.2020.100347
Autori:
Gener, Rafael, Seras-Franzoso, Perez, Pindado, Casas, Arango, Fernández, Díaz-Riascos, Abasolo, Schwartz
Pubblicato in:
Cancers, Numero 11/8, 2019, Pagina/e 1058, ISSN 2072-6694
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers11081058
Autori:
Marina Kovacevic, Igor Balaz, Domenico Marson, Erik Laurini, Branislav Jovic
Pubblicato in:
Biosystems, Numero 202, 2021, ISSN 0303-2647
Editore:
Elsevier BV
DOI:
10.1016/j.biosystems.2021.104354
Autori:
Michail-Antisthenis I. Tsompanas; Larry Bull; Andrew Adamatzky; Igor Balaz
Pubblicato in:
IEEE Computational Intelligence Magazine, Numero 7, 2021, ISSN 1556-603X
Editore:
Institute of Electrical and Electronics Engineers
DOI:
10.1109/mci.2021.3108306
Autori:
Igor Balaz; Tara Petric; Namid R. Stillman
Pubblicato in:
ALIFE 2021: The 2021 Conference on Artificial Life, 2021
Editore:
MIT Press
DOI:
10.1162/isal_a_00435
Autori:
Pere Molins, Namid Stillman, Sabine Hauert
Pubblicato in:
Cybernetics and Systems, Numero 50, 2019, Pagina/e 693-710
Editore:
Taylor & Francis
DOI:
10.1080/01969722.2019.1677336
Autori:
Tsompanas, Michail-Antisthenis; Bull, Larry; Adamatzky, Andrew; Balaz, Igor
Pubblicato in:
Modern Trends in Controlled Stochastic Processes, Numero 1, 2021, Pagina/e 328-340
Editore:
Springer
DOI:
10.1007/978-3-030-76928-4_17
Autori:
Tsompanas, Michail-Antisthenis; Bull, Larry; Adamatzky, Andrew; Balaz, Igor
Pubblicato in:
Numero 4, 2019
Editore:
arXiv
Autori:
Stillman, Namid; Balazs, Igor; Hauert, Sabine
Pubblicato in:
ArXiv Machine Learning, Numero 2, 2020
Editore:
ArXiv
DOI:
10.48550/arxiv.2010.04512
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