Building a 3D innervated and irrigated muscle on a chip.

Livrables

Implementation of the gene editing method

Characterization of perfused and innervated muscle
Design of multi-tubular microchannels

Production and presentation of the project website and logo

Presentation of a Market report

Final Annual Project Meeting with the presence of the SAB
Second Annual Project Meeting with the presence of the SAB
Third Annual Project Meeting with the presence of the SAB
First Annual Project Meeting with the presence of the SAB

Data Management Plan

Presentation of the Data management plan

Publications

Remote Magnetic Microengineering and Alignement of Spheroids into 3D Cellular Fibers

Auteurs: Noam Demri, Simon Dumas, Manh-Louis Nguyen, Giacomo Gropplero, Ali Abou-Hassan, Stéphanie Descroix, Claire Wilhelm
Publié dans: Advanced Functional Materials, 2022, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202204850

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Auteurs: Barbacena, Pedro; Dominguez-Cejudo, Maria Angeles; Fonseca, Catarina; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, Andreia; Pezzarossa, Anna; Ramalho, Daniela; Giarratano, Ylenia; Ouarné, Marie; Barata, David; Fortunato, Isabela C.; Henao Mišíková, Lenka; Mauldin, Ian; Carvalho, Yulia; Trepat, Xavier; RocaCusachs, Pere; Eichmann, Anne; Bernabeu, Miguel O.; Franco, Claudio
Publié dans: Developmental Cell, 2022, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Spatio-temporal dynamics of dilute red blood cell suspensions in a microchannel flow at low Reynolds number

Auteurs: Zhou, Qi; Fidalgo, Joana; Calvi, Lavinia; Bernabeu, Miguel O.; Hoskins, Peter R.; Oliveira, Mónica S. N.; Krüger, Timm
Publié dans: Biophysical Journal, 2020, ISSN 1542-0086
Éditeur: Elsevier, Cell Press
DOI: 10.1016/j.bpj.2020.03.019

Wasp Controls Oriented Migration of Endothelial Cells to Achieve Functional Vascular Patterning.

Auteurs: Holger Gerhardt; Andre Rosa; Katja Meier; Wolfgang Giese; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; A. Symborska-Mell; Baptiste Coxam; Miguel O. Bernabeu
Publié dans: Devolopment, 2022, ISSN 1477-9129
Éditeur: The company of Biologists
DOI: 10.1101/2020.09.15.296574

Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation

Auteurs: Miguel O. Bernabeu; Jakub Köry; James A. Grogan; Bostjan Markelc; Albert Beardo; Mayeul d'Avezac; Romain Enjalbert; Jakob Kaeppler; Nicholas Daly; James Hetherington; Timm Krüger; Philip K. Maini; Joe Pitt-Francis; Ruth J. Muschel; Tomás Alarcón; Helen M. Byrne
Publié dans: PNAS, 2020, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2007770117

Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations

Auteurs: Qi Zhou; Joana Fidalgo; Miguel O. Bernabeu; Monica Oliveira; Timm Krüger
Publié dans: Soft Matter, 2021, ISSN 1744-6848
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0sm01845g

Generating fast-twitch myotubes in vitro using an optogenetic-based, quantitative contractility assay

Auteurs: Hennig K, Hardman D, Barata D, Martins I, Bernabeu MO, Gomes ER, Roman W.
Publié dans: Life Science Alliance, 2023, ISSN 1879-0631
Éditeur: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Association between erythrocyte dynamics and vessel remodeling in developmental vascular networks

Auteurs: Qi Zhou; Tijana Perovic; Ines Fechner; Lowell T. Edgar; Peter R. Hoskins; Peter R. Hoskins; Holger Gerhardt; Timm Krüger; Miguel O. Bernabeu
Publié dans: Journal of The Royal Society Interface, 2021, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1098/rsif.2021.0113

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