Building a 3D innervated and irrigated muscle on a chip.

Informazioni relative al progetto

MyoChip

ID dell’accordo di sovvenzione: 801423

DOI

10.3030/801423

Progetto chiuso

Data della firma CE 4 Maggio 2018

Data di avvio 1 Novembre 2018

Data di completamento 30 Aprile 2023

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 153 553,74

Contributo UE

€ 3 153 553,74

Coordinato da

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (3)

Gene editing method

Implementation of the gene editing method

Characterization of perfused and innervated muscle
Design of multi-tubular microchannels

Websites, patent fillings, videos etc. (1)

Project website and logo

Production and presentation of the project website and logo

Documents, reports (5)

Market report

Presentation of a Market report

Final Annual Project Meeting with the presence of the SAB
Second Annual Project Meeting with the presence of the SAB
Third Annual Project Meeting with the presence of the SAB
First Annual Project Meeting with the presence of the SAB

Open Research Data Pilot (1)

Data Management Plan

Presentation of the Data management plan

Pubblicazioni

Peer reviewed articles (8)

Remote Magnetic Microengineering and Alignement of Spheroids into 3D Cellular Fibers

Autori: Noam Demri, Simon Dumas, Manh-Louis Nguyen, Giacomo Gropplero, Ali Abou-Hassan, Stéphanie Descroix, Claire Wilhelm
Pubblicato in: Advanced Functional Materials, 2022, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202204850

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Autori: Barbacena, Pedro; Dominguez-Cejudo, Maria Angeles; Fonseca, Catarina; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, Andreia; Pezzarossa, Anna; Ramalho, Daniela; Giarratano, Ylenia; Ouarné, Marie; Barata, David; Fortunato, Isabela C.; Henao Mišíková, Lenka; Mauldin, Ian; Carvalho, Yulia; Trepat, Xavier; RocaCusachs, Pere; Eichmann, Anne; Bernabeu, Miguel O.; Franco, Claudio
Pubblicato in: Developmental Cell, 2022, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Spatio-temporal dynamics of dilute red blood cell suspensions in a microchannel flow at low Reynolds number

Autori: Zhou, Qi; Fidalgo, Joana; Calvi, Lavinia; Bernabeu, Miguel O.; Hoskins, Peter R.; Oliveira, Mónica S. N.; Krüger, Timm
Pubblicato in: Biophysical Journal, 2020, ISSN 1542-0086
Editore: Elsevier, Cell Press
DOI: 10.1016/j.bpj.2020.03.019

Wasp Controls Oriented Migration of Endothelial Cells to Achieve Functional Vascular Patterning.

Autori: Holger Gerhardt; Andre Rosa; Katja Meier; Wolfgang Giese; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; A. Symborska-Mell; Baptiste Coxam; Miguel O. Bernabeu
Pubblicato in: Devolopment, 2022, ISSN 1477-9129
Editore: The company of Biologists
DOI: 10.1101/2020.09.15.296574

Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation

Autori: Miguel O. Bernabeu; Jakub Köry; James A. Grogan; Bostjan Markelc; Albert Beardo; Mayeul d'Avezac; Romain Enjalbert; Jakob Kaeppler; Nicholas Daly; James Hetherington; Timm Krüger; Philip K. Maini; Joe Pitt-Francis; Ruth J. Muschel; Tomás Alarcón; Helen M. Byrne
Pubblicato in: PNAS, 2020, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2007770117

Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations

Autori: Qi Zhou; Joana Fidalgo; Miguel O. Bernabeu; Monica Oliveira; Timm Krüger
Pubblicato in: Soft Matter, 2021, ISSN 1744-6848
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sm01845g

Generating fast-twitch myotubes in vitro using an optogenetic-based, quantitative contractility assay

Autori: Hennig K, Hardman D, Barata D, Martins I, Bernabeu MO, Gomes ER, Roman W.
Pubblicato in: Life Science Alliance, 2023, ISSN 1879-0631
Editore: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Association between erythrocyte dynamics and vessel remodeling in developmental vascular networks

Autori: Qi Zhou; Tijana Perovic; Ines Fechner; Lowell T. Edgar; Peter R. Hoskins; Peter R. Hoskins; Holger Gerhardt; Timm Krüger; Miguel O. Bernabeu
Pubblicato in: Journal of The Royal Society Interface, 2021, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1098/rsif.2021.0113