Building a 3D innervated and irrigated muscle on a chip.

Información del proyecto

MyoChip

Identificador del acuerdo de subvención: 801423

DOI

10.3030/801423

Proyecto cerrado

Fecha de la firma de la CE 4 Mayo 2018

Fecha de inicio 1 Noviembre 2018

Fecha de finalización 30 Abril 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 153 553,74

Aportación de la UE

€ 3 153 553,74

Coordinado por

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (3)

Gene editing method

Implementation of the gene editing method

Characterization of perfused and innervated muscle
Design of multi-tubular microchannels

Websites, patent fillings, videos etc. (1)

Project website and logo

Production and presentation of the project website and logo

Documents, reports (5)

Market report

Presentation of a Market report

Final Annual Project Meeting with the presence of the SAB
Second Annual Project Meeting with the presence of the SAB
Third Annual Project Meeting with the presence of the SAB
First Annual Project Meeting with the presence of the SAB

Open Research Data Pilot (1)

Data Management Plan

Presentation of the Data management plan

Publicaciones

Peer reviewed articles (8)

Remote Magnetic Microengineering and Alignement of Spheroids into 3D Cellular Fibers

Autores: Noam Demri, Simon Dumas, Manh-Louis Nguyen, Giacomo Gropplero, Ali Abou-Hassan, Stéphanie Descroix, Claire Wilhelm
Publicado en: Advanced Functional Materials, 2022, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202204850

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Autores: Barbacena, Pedro; Dominguez-Cejudo, Maria Angeles; Fonseca, Catarina; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, Andreia; Pezzarossa, Anna; Ramalho, Daniela; Giarratano, Ylenia; Ouarné, Marie; Barata, David; Fortunato, Isabela C.; Henao Mišíková, Lenka; Mauldin, Ian; Carvalho, Yulia; Trepat, Xavier; RocaCusachs, Pere; Eichmann, Anne; Bernabeu, Miguel O.; Franco, Claudio
Publicado en: Developmental Cell, 2022, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Spatio-temporal dynamics of dilute red blood cell suspensions in a microchannel flow at low Reynolds number

Autores: Zhou, Qi; Fidalgo, Joana; Calvi, Lavinia; Bernabeu, Miguel O.; Hoskins, Peter R.; Oliveira, Mónica S. N.; Krüger, Timm
Publicado en: Biophysical Journal, 2020, ISSN 1542-0086
Editor: Elsevier, Cell Press
DOI: 10.1016/j.bpj.2020.03.019

Wasp Controls Oriented Migration of Endothelial Cells to Achieve Functional Vascular Patterning.

Autores: Holger Gerhardt; Andre Rosa; Katja Meier; Wolfgang Giese; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; A. Symborska-Mell; Baptiste Coxam; Miguel O. Bernabeu
Publicado en: Devolopment, 2022, ISSN 1477-9129
Editor: The company of Biologists
DOI: 10.1101/2020.09.15.296574

Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation

Autores: Miguel O. Bernabeu; Jakub Köry; James A. Grogan; Bostjan Markelc; Albert Beardo; Mayeul d'Avezac; Romain Enjalbert; Jakob Kaeppler; Nicholas Daly; James Hetherington; Timm Krüger; Philip K. Maini; Joe Pitt-Francis; Ruth J. Muschel; Tomás Alarcón; Helen M. Byrne
Publicado en: PNAS, 2020, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2007770117

Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations

Autores: Qi Zhou; Joana Fidalgo; Miguel O. Bernabeu; Monica Oliveira; Timm Krüger
Publicado en: Soft Matter, 2021, ISSN 1744-6848
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sm01845g

Generating fast-twitch myotubes in vitro using an optogenetic-based, quantitative contractility assay

Autores: Hennig K, Hardman D, Barata D, Martins I, Bernabeu MO, Gomes ER, Roman W.
Publicado en: Life Science Alliance, 2023, ISSN 1879-0631
Editor: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Association between erythrocyte dynamics and vessel remodeling in developmental vascular networks

Autores: Qi Zhou; Tijana Perovic; Ines Fechner; Lowell T. Edgar; Peter R. Hoskins; Peter R. Hoskins; Holger Gerhardt; Timm Krüger; Miguel O. Bernabeu
Publicado en: Journal of The Royal Society Interface, 2021, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1098/rsif.2021.0113