Influenza Virus - Sugar Interactions, From Glycan Arrays To Better Vaccines

Project Information

Sugar-Enable

Grant agreement ID: 802780

DOI 10.3030/802780

Project closed

EC signature date 26 November 2018

Start date 1 December 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 441 681,00

EU contribution € 1 441 681,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

Publications

Peer reviewed articles (19)

Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses

Author(s): Frederik Broszeit, Rosanne J. van Beek, Luca Unione, Theo M. Bestebroer, Digantkumar Chapla, Jeong-Yeh Yang, Kelley W. Moremen, Sander Herfst, Ron A. M. Fouchier, Robert P. de Vries & Geert-Jan Boons
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25713-1

N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus

Author(s): Cindy M. Spruit, Nikoloz Nemanichvili, Masatoshi Okamatsu, Hiromu Takematsu, Geert-Jan Boons, Robert P. de Vries
Published in: Viruses, Issue 13/5, 2021, Page(s) 815, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050815

The Intestinal Microbiota Contributes To The Control Of Highly Pathogenic H5N9 Influenza Virus Replication In Ducks

Author(s): Thomas Figueroa; Pierre Bessière; Amelia Coggon; Roosmarijn van der Woude; Maxence Delverdier; Monique H. Verheije; Robert P. de Vries; Romain Volmer
Published in: Journal of Virology, Issue 1, 2020, ISSN 1098-5514
Publisher: ASM
DOI: 10.1101/778258

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection

Author(s): Cindy M. Spruit; Igor R. Sweet; Theo Bestebroer; Pascal Lexmond; Boning Qiu; Mirjam J.A. Damen; Ron A. M. Fouchier; Joost Snijder; Sander Herfst; Geert-Jan Boons; Robert P. de Vries
Published in: Glycobiology, Issue 5, 2023, ISSN 1460-2423
Publisher: Oxford
DOI: 10.1101/2022.11.16.516725

Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney Tissue

Author(s): Kim M. Bouwman, Lisa M. Parsons, Alinda J. Berends, Robert P. de Vries, John F. Cipollo, Monique H. Verheije
Published in: Journal of Virology, Issue 94/2, 2020, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01363-19

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Author(s): Arunkumar, Guha Asthagiri; Bhavsar, Disha; Li, Tiehai; Strohmeier, Shirin; Chromikova, Veronika; Amanat, Fatima; Bunyatov, Mehman; Wilson, Patrick C.; Ellebedy, Ali H.; Boons, Geert Jan; Simon, Viviana; de Vries, Robert P.; Krammer, Florian; Afd Chemical Biology and Drug Discovery; Sub Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery
Published in: Nature Communications, Issue 1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2021.01.04.425274

Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2

Author(s): Liu, Lin; Chopra, Pradeep; Li, Xiuru; Bouwman, Kim M; Tompkins, S Mark; Wolfert, Margreet A; de Vries, Robert P; Boons, Geert-Jan; Chemical Biology and Drug Discovery; Afd Chemical Biology and Drug Discovery; Sub Chemical Biology and Drug Discovery
Published in: ACS Central Science, Issue 1, 2020, ISSN 2374-7943
Publisher: ACS
DOI: 10.1101/2020.05.10.087288

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Author(s): Linh Nguyen, Kelli A. McCord, Duong T. Bui, Kim M. Bouwman, Elena N. Kitova, Mohamed Elaish, Dhanraj Kumawat, Gour C. Daskhan, Ilhan Tomris, Ling Han, Pradeep Chopra, Tzu-Jing Yang, Steven D. Willows, Andrew L. Mason, Lara K. Mahal, Todd L. Lowary, Lori J. West, Shang-Te Danny Hsu, Tom Hobman, Stephen M. Tompkins, Geert-Jan Boons, Robert P. de Vries, Matthew S. Macauley & John S. Klassen
Published in: Nature Chemical Biology, 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-021-00924-1

SARS-CoV-2 Spike N-Terminal Domain Engages 9-<i>O</i>-Acetylated α2–8-Linked Sialic Acids

Author(s): Ilhan Tomris; Luca Unione; Linh Nguyen; Pouya Zaree; Kim M. Bouwman; Lin Liu; Zeshi Li; Jelle A. Fok; María Ríos Carrasco; Roosmarijn van der Woude; Anne L. M. Kimpel; Mirte W. Linthorst; Sinan E. Kilavuzoglu; Enrico C. J. M. Verpalen; Tom G. Caniels; Rogier W. Sanders; Balthasar A. Heesters; Roland J. Pieters; Jesús Jiménez-Barbero; John S. Klassen; Geert-Jan Boons; Robert P. de Vries
Published in: ACS Chemical Biology, Issue 1, 2023, ISSN 1554-8937
Publisher: ACS
DOI: 10.1021/acschembio.3c00066

Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N -Glycan Subtypes in Host-Pathogen Interactions

Author(s): Lisa M. Parsons, Yanming An, Li Qi, Mitchell R. White, Roosmarijn van der Woude, Kevan L. Hartshorn, Jeffery K. Taubenberger, Robert P. de Vries, John F. Cipollo
Published in: Journal of Virology, Issue 94/5, 2020, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01951-19

N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses

Author(s): Frederik Broszeit, Netanel Tzarum, Xueyong Zhu, Nikoloz Nemanichvili, Dirk Eggink, Tim Leenders, Zeshi Li, Lin Liu, Margreet A. Wolfert, Andreas Papanikolaou, Carles Martínez-Romero, Ivan A. Gagarinov, Wenli Yu, Adolfo García-Sastre, Tom Wennekes, Masatoshi Okamatsu, Monique H. Verheije, Ian A. Wilson, Geert-Jan Boons, Robert P. de Vries
Published in: Cell Reports, Issue 27/11, 2019, Page(s) 3284-3294.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.05.048

Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids

Author(s): Nemanichvili, Nikoloz; Spruit, Cindy M; Berends, Alinda J; Gröne, Andrea; Rijks, Jolianne M; Verheije, Monique H; de Vries, Robert P; dPB I&I; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; dI&I I&I-1; VPDC pathologie; dPB CR
Published in: Glycobiology, Issue 1, 2021, ISSN 0959-6658
Publisher: Oxford University Press
DOI: 10.1093/glycob/cwac033

Well-Defined Heparin Mimetics Can Inhibit Binding of the Trimeric Spike of SARS-CoV-2 in a Length-Dependent Manner

Author(s): Lifeng Sun; Pradeep Chopra; Ilhan Tomris; Roosmarijn van der Woude; Lin Liu; Robert P. de Vries; Geert-Jan Boons
Published in: JACS au, Issue 1, 2023, ISSN 2691-3704
Publisher: ACS
DOI: 10.1021/jacsau.3c00042

Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells.

Author(s): Heesters, Balthasar A; van Megesen, Kyah; Tomris, Ilhan; de Vries, Robert P; Magri, Giuliana; Spits, Hergen; Afd Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery
Published in: The Journal of Experimental Medicine, Issue 1, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20210790

Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans

Author(s): Canales, Angeles; Sastre, Javier; Orduña, Jose M.; Spruit, Cindy M.; Pérez-Castells, Javier; Domínguez, Gema; Bouwman, Kim M.; van der Woude, Roosmarijn; Cañada, Francisco Javier; Nycholat, Corwin M.; Paulson, James C.; Boons, Geert Jan; Jiménez-Barbero, Jesús; de Vries, Robert P.; Afd Chemical Biology and Drug Discovery; Sub Chemical Biology and Drug Discovery; Chemical Biology and Drug Dis
Published in: JACS Au, Issue 1, 2022, ISSN 2691-3704
Publisher: ACS
DOI: 10.1021/jacsau.2c00664

Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells

Author(s): Roosmarijn Woude, Hannah L. Turner, Ilhan Tomris, Kim M. Bouwman, Andrew B. Ward, Robert P. Vries
Published in: Protein Science, Issue 29/9, 2020, Page(s) 1975-1982, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.3918

Hierarchical Multivalent Effects Control Influenza Host Specificity

Author(s): Nico J. Overeem, P. H. Erik Hamming, Oliver C. Grant, Daniele Di Iorio, Malte Tieke, M. Candelaria Bertolino, Zeshi Li, Gaël Vos, Robert P. de Vries, Robert J. Woods, Nicholas B. Tito, Geert-Jan P. H. Boons, Erhard van der Vries, Jurriaan Huskens
Published in: ACS Central Science, Issue 6/12, 2020, Page(s) 2311-2318, ISSN 2374-7943
Publisher: ACS
DOI: 10.1021/acscentsci.0c01175

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

Author(s): Kim M. Bouwman, Ilhan Tomris, Hannah L. Turner, Roosmarijn van der Woude, Tatiana M. Shamorkina, Gerlof P. Bosman, Barry Rockx, Sander Herfst, Joost Snijder, Bart L. Haagmans, Andrew B. Ward, Geert-Jan Boons, Robert P. de Vries
Published in: PLOS Pathogens, Issue 17/2, 2021, Page(s) e1009282, ISSN 1553-7374
Publisher: Plos Pathogens
DOI: 10.1371/journal.ppat.1009282

Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

Author(s): Tomris, Ilhan; Bouwman, Kim M; Adolfs, Youri; Noack, Danny; van der Woude, Roosmarijn; Kerster, Gius; Herfst, Sander; Sanders, Rogier W; van Gils, Marit J; Boons, Geert-Jan; Haagmans, Bart L; Pasterkamp, R Jeroen; Rockx, Barry; de Vries, Robert P; Afd Chemical Biology and Drug Discovery; dPB I&I; Sub Chemical Biology and Drug Discovery
Published in: Plos Pathogens, Issue 1, 2021, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1010340

Non-peer reviewed articles (1)

Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals.

Author(s): Nemanichvili, Nikoloz; Berends, Alinda J; Wubbolts, Richard W; Gröne, Andrea; Rijks, Jolianne M; de Vries, Robert P; Verheije, Monique H; VP pathologie; dI&I I&I-1; dPB I&I; Celbiologie; IOV CCB; dB&C I&I; dPB CR; VPDC pathologie; Afd Chemical Biology and Drug Discovery; Pharmacology; Chemical Biology and Drug Discovery
Published in: Viruses, Issue 1, 2021, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040586