Pubblicazioni Peer reviewed articles (19) Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells Autori: Redouane Aherrahrou, Liang Guo, V. Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F. Alencar, Arjan Boltjes, Sander W. van der Laan, Emily Farber, Daniela Fuller, Rita Anane-Wae, Ngozi Akingbesote, Ani W. Manichaikul, Lijiang Ma, Minna U. Kaikkonen, Johan L.M. Björkegren, Suna Önengüt-Gümüşcü, Gerard Pasterkamp, Clint L. Miller, Gary K. Owens, Alok Pubblicato in: Circulation Research, Issue 127/12, 2020, Page(s) 1552-1565, ISSN 0009-7330 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.120.317415 Elevated circulating follistatin associates with an increased risk of type 2 diabetes Autori: Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali Pubblicato in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-021-26536-w Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models Autori: Austin C. Conklin, Hitoo Nishi, Florencia Schlamp, Tiit Örd, Kadri Õunap, Minna U. Kaikkonen, Edward A. Fisher, Casey E. Romanoski Pubblicato in: Immunometabolism, 2021, ISSN 2633-0407 Editore: Hapres Limited DOI: 10.20900/immunometab20210022 Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci Autori: Tiit Örd, Kadri Õunap, Lindsey K. Stolze, Redouane Aherrahrou, Valtteri Nurminen, Anu Toropainen, Ilakya Selvarajan, Tapio Lönnberg, Einari Aavik, Seppo Ylä-Herttuala, Mete Civelek, Casey E. Romanoski, Minna U. Kaikkonen Pubblicato in: Circulation Research, Issue 129/2, 2021, Page(s) 240-258, ISSN 0009-7330 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.121.318971 Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics Autori: Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P Pubblicato in: Circulation Research, Issue 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.120.316770 The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium Autori: Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D Nguyen, Sinem Karaman, Emilia A Korhonen, Ralf H Adams, Hellmut G Augustin, Katariina Öörni, Oliver Soehnlein, Minna U Kaikkonen, Kari Alitalo Pubblicato in: Nature Cardiovascular Research, Issue Mar 13;2(3), 2022, Page(s) 307-321, ISSN 2731-0590 Editore: Nature Portfolio DOI: 10.1038/s44161-023-00224-y Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes Autori: Rédouane Aherrahrou, Dillon Lue, R Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan, Joon Yuhl Soh, Tiit Örd, Prosanta Singha, Qianyi Yang, Huda Gilani, Ernest Diez Benavente 4 , Doris Wong, Jameson Hinkle, Lijiang Ma, Gloria M Sheynkman, Hester M den Ruijter, Clint L Miller, Johan L M Björkegren, Minna U Kaikkonen, Mete Civelek Pubblicato in: Circulation Research, Issue Feb 3;132(3), 2023, Page(s) 323-338, ISSN 0009-7330 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.122.321586 The Power of Single-Cell RNA Sequencing in eQTL Discovery Autori: Maleeha Maria, Negar Pouyanfar, Tiit Örd, Minna U Kaikkonen Pubblicato in: Genes, Issue Mar 12;13(3), 2022, Page(s) 502, ISSN 2073-4425 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/genes13030502 The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages Autori: Huang, Zhiqiang; Liang, Ning; Goñi, Saioa; Damdimopoulos, Anastasios; Wang, Cheng; Ballaire, Raphaelle; Jager, Jennifer; Niskanen, Henri; Han, HongYa; Jakobsson, Tomas; Bracken, Adrian,; Aouadi, Myriam; Venteclef, Nicolas; Kaikkonen, Minna,; Fan, Rongrong; Treuter, Eckardt Pubblicato in: Molecular Cell, Issue 81/5, 2021, ISSN 1097-2765 Editore: Cell Press DOI: 10.1016/j.molcel.2020.12.040 Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures Autori: Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Õunap, Maleeha Maria, Pierre R Moreau, Pashupati P Mishra, Senthil Palani, Jenni Virta, Heidi Liljenbäck, Einari Aavik, Anne Roivainen, Seppo Ylä-Herttuala, Johanna P Laakkonen, Terho Lehtimäki, Minna U Kaikkonen Pubblicato in: American Journal of Human Genetics, Issue May 4;110(5), 2023, Page(s) 722-740, ISSN 0002-9297 Editore: University of Chicago Press DOI: 10.1016/j.ajhg.2023.03.013 Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types Autori: Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Õunap, Tiit Örd, Heidi H. Pulkkinen, Petri Pölönen, Merja Heinäniemi, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 41/7, 2021, Page(s) 2149-2167, ISSN 1079-5642 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/atvbaha.121.315579 Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease Autori: Ilakya Selvarajan, Anu Toropainen, Kristina M. Garske, Maykel López Rodríguez, Arthur Ko, Zong Miao, Dorota Kaminska, Kadri Õunap, Tiit Örd, Aarthi Ravindran, Oscar H. Liu, Pierre R. Moreau, Ashik Jawahar Deen, Ville Männistö, Calvin Pan, Anna-Liisa Levonen, Aldons J. Lusis, Sami Heikkinen, Casey E. Romanoski, Jussi Pihlajamäki, Päivi Pajukanta, Minna U. Kaikkonen Pubblicato in: The American Journal of Human Genetics, Issue 108/3, 2021, Page(s) 411-430, ISSN 0002-9297 Editore: University of Chicago Press DOI: 10.1016/j.ajhg.2021.02.006 Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis Autori: Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam Pubblicato in: Nucleic Acids Research, 2021, ISSN 0305-1048 Editore: Oxford University Press DOI: 10.1093/nar/gkab633 NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli Autori: Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivelä, Juha Hartikainen, Mikko Hippeläinen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U Kaikkonen Pubblicato in: Cardiovascular Research, Issue Jul 19, 2020, ISSN 0008-6363 Editore: Elsevier BV DOI: 10.1093/cvr/cvaa219 Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA Autori: Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta Pubblicato in: Hepatology Communications, Issue 3/10, 2019, Page(s) 1356-1372, ISSN 2471-254X Editore: American Association for the Study of Liver Diseases DOI: 10.1002/hep4.1413 Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits Autori: Lindsey K. Stolze, Austin C. Conklin, Michael B. Whalen, Maykel López Rodríguez, Kadri Õunap, Ilakya Selvarajan, Anu Toropainen, Tiit Örd, Jin Li, Anna Eshghi, Alice E. Solomon, Yun Fang, Minna U. Kaikkonen, Casey E. Romanoski Pubblicato in: The American Journal of Human Genetics, Issue 106/6, 2020, Page(s) 748-763, ISSN 0002-9297 Editore: University of Chicago Press DOI: 10.1016/j.ajhg.2020.04.008 Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation Autori: Leena E. Viiri, Tommi Rantapero, Mostafa Kiamehr, Anna Alexanova, Mikko Oittinen, Keijo Viiri, Henri Niskanen, Matti Nykter, Minna U. Kaikkonen, Katriina Aalto-Setälä Pubblicato in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-019-39215-0 Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells Autori: Isidore Mushimiyimana, Vanesa Tomas Bosch, Henri Niskanen, Nicholas L. Downes, Pierre R. Moreau, Kiley Hartigan, Seppo Ylä-Herttuala, Nihay Laham-Karam, Minna U. Kaikkonen Pubblicato in: Molecular and Cellular Biology, Issue 41/7, 2021, ISSN 0270-7306 Editore: American Society for Microbiology DOI: 10.1128/mcb.00594-20 Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease Autori: Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee, David Z Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N Benhammou, Martin Wabitsch, Joseph R Pisegna, Ville Männistö, Kirsi H Pietiläinen, Markku Laakso, Janet S Sinsheimer, Minna U Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta Pubblicato in: EBioMedicine, Issue Jun;92, 2023, Page(s) 104620, ISSN 2352-3964 Editore: Elsevier BV DOI: 10.1016/j.ebiom.2023.104620 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
