How distress alters opioid drug effects and abuse liability

Project Information

OPIOIDREWARD

Grant agreement ID: 802885

DOI

10.3030/802885

Project closed

EC signature date 26 June 2019

Start date 1 July 2019

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (8)

Intoxication and Other Subjective Effects of Preoperative Opioids: A Randomized Controlled Trial

Author(s): Siri Gurandsrud Karlsen, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Harald Lenz, Marlin Comelon, Silvana De Pirro, Chantal Berna, Eric L. Garland, Gernot Ernst, Siri Leknes, Marie Eikemo
Published in: Sneek Peek Preprint, 2025
Publisher: CelPress, Elsevier

Minor role of endogenous opioids for acute pain regulation in humans: a systematic review and meta-analysis of placebo-controlled antagonist studies

Author(s): Isabell M. Meier, Martin Trøstheim, Eira Nordeng Jensen, Mathias Nikolai Roland, Guro Engvig Løseth, Marie Eikemo, Siri Leknes
Published in: 2025
Publisher: Center for Open Science
DOI: 10.31219/osf.io/bvfje_v1

Stress-enhanced opioid self-administration in healthy men: A randomized controlled experimental medicine study

Author(s): Marie Eikemo, Guro Engvig Løseth, Molly Carlyle, Martin Trøstheim, Gernot Ernst, Claudia Pazmandi, Matthew Thompson, Cecilia Vezzani, Isabell M. Meier, Tom Johnstone, Markus Heilig, Guido Biele, and Siri Leknes
Published in: Preprint, 2024
Publisher: n/a
DOI: 10.31219/osf.io/v8dxy

Endogenous Mu-Opioid Modulation of Social Connection in Humans: A Systematic Review and Meta-Analysis

Author(s): Guro Engvig Løseth, Martin Trøstheim, and Siri Leknes
Published in: Preprint, 2023
Publisher: n/a
DOI: 10.31234/osf.io/gha86

Justify your disability! A simulated medical evaluation as a robust novel stress induction paradigm in chronic pain patients

Author(s): Aimie Chiron, Aurore Fernandez, Léa Schmidt, Sonia Plaza-Wüthrich, Marc R. Suter, Siri Leknes, Chantal Berna
Published in: bioRxiv The preprint server for biology, 2026
Publisher: openRxiv
DOI: 10.1101/2024.07.03.601919

Experimental Pain Responses and Clinical Pain Symptoms in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Author(s): Martin Trøstheim, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Published in: OSF Preprints, 2025
Publisher: Center for Open Science
DOI: 10.31234/osf.io/9umb4_v1

Stress recovery with social support: A dyadic stress and support task

Author(s): Guro Engvig Løseth, Marie Eikemo, Martin Trøstheim, Isabell M. Meier, Herman Bjørnstad, Anna Asratian, Claudia Pazmandi, Vegard Wathne Tangen, Markus Heilig, Siri Leknes
Published in: preprint, 2022
Publisher: Open Science Framework

Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade

Author(s): Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost, Siri Leknes
Published in: preprint, 2022
Publisher: Open Science Framework
DOI: 10.1101/2022.02.25.481943

Peer reviewed articles (14)

Do endogenous opioids mediate or fine-tune human pain relief?

Author(s): Marie Eikemo, Guro Løseth, Siri Leknes
Published in: PAIN, 2021, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002286

Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology

Author(s): Siri Leknes, Lauren Y. Atlas
Published in: British Journal of Anaesthesia, Issue 124/3, 2020, Page(s) e29-e33, ISSN 0007-0912
Publisher: Oxford University Press
DOI: 10.1016/j.bja.2019.10.006

Opioid analgesic effects on subjective well‐being in the operating theatre*

Author(s): M. Eikemo; I. M. Meier; G. E. Løseth; M. Trøstheim; N. Ørstavik; E. N. Jensen; E. L. Garland; C. Berna; G. Ernst; S. Leknes
Published in: Anaesthesia, Issue vol. 78, no. 9, 2023, Page(s) 1102-1111, ISSN 0003-2409
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/anae.16069

Stress recovery with social support: A dyadic stress and support task

Author(s): Guro Engvig Løseth; Marie Eikemo; Martin Trøstheim; Isabell M. Meier; Herman Bjørnstad; Anna Asratian; Claudia Pazmandi; Vegard Wathne Tangen; Markus Heilig; Siri Leknes
Published in: Psychoneuroendocrinology, Issue 146, 2022, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105949

Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis

Author(s): Guro Løseth, Martin Trøstheim, Siri Leknes
Published in: Translational Psychiatry, Issue 14, 2024, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-024-03088-3

Assessment of Anhedonia in Adults With and Without Mental Illness

Author(s): Martin Trøstheim, Marie Eikemo, Remy Meir, Ingelin Hansen, Elisabeth Paul, Sara Liane Kroll, Eric L. Garland, Siri Leknes
Published in: JAMA Network Open, Issue 3/8, 2020, Page(s) e2013233, ISSN 2574-3805
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2020.13233

Factors associated with use of opioid rescue medication after surgery

Author(s): Isabell M Meier; Marie Eikemo; Martin Trøstheim; Kaja Buen; Eira Jensen; Siri Gurandsrud Karlsen; Silje E Reme; Chantal Berna; Siri Leknes; Gernot Ernst
Published in: Regional Anesthesia & Pain Medicine, Issue 1, 2023, ISSN 1532-8651
Publisher: American Society of Regional Anesthesia and Pain Medicine
DOI: 10.1136/rapm-2023-104412

Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery

Author(s): Molly Carlyle, Malin Kvande, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo
Published in: Addiction Research Theory, Issue 32, 2024, Page(s) 46-57, ISSN 1606-6359
Publisher: Brunner - Routledge (US)
DOI: 10.1080/16066359.2023.2211348

Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Author(s): Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost & Siri Leknes
Published in: Neuropsychopharmacology, Issue 48, 2022, Page(s) 299-307, ISSN 1740-634X
Publisher: Springer Nature
DOI: 10.1038/s41386-022-01416-z

Opioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction

Author(s): Guro Løseth, Marie Eikemo, Siri Leknes
Published in: Biological Psychiatry, Issue 97, 2025, Page(s) 971-981, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2024.11.011

The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies

Author(s): Isabell M. Meier, Marie Eikemo, Siri Leknes
Published in: Current Addiction Reports, Issue 3, 2021, Page(s) 306-318, ISSN 2196-2952
Publisher: Springer Link
DOI: 10.1007/s40429-021-00366-8

Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men

Author(s): Morgan Scarth, Lisa Evju Hauger, Per Medbøe Thorsby, Siri Leknes, Ingunn R Hullstein, Lars T. Westlye, Astrid Bjørnebekk
Published in: Psychopharmacology, Issue 241, 2024, Page(s) 701-715, ISSN 0033-3158
Publisher: Springer Verlag
DOI: 10.1007/s00213-023-06497-2

Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers

Author(s): Molly Carlyle, Harriet de Wit, Siri Leknes
Published in: Journal of Psychopharmacology, Issue 38, 2025, Page(s) 986-997, ISSN 0269-8811
Publisher: SAGE Publications
DOI: 10.1177/02698811241268892

Reward Sensitivity in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Author(s): Martin Trøstheim, Mads Lund Pedersen, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Philipp Paul Lobmaier, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Issue 10, 2026, Page(s) 1166-1176, ISSN 2451-9022
Publisher: Elsevier BV
DOI: 10.1016/j.bpsc.2025.04.013

Non-peer reviewed articles (1)

Understanding individual variability in opioid responses: A call to arms

Author(s): Siri Leknes, Marie Eikemo, Guro Løseth
Published in: Addiction Biology, Issue 29, 2024, ISSN 1355-6215
Publisher: Taylor & Francis
DOI: 10.1111/adb.13418