How distress alters opioid drug effects and abuse liability

Información del proyecto

OPIOIDREWARD

Identificador del acuerdo de subvención: 802885

DOI

10.3030/802885

Proyecto cerrado

Fecha de la firma de la CE 26 Junio 2019

Fecha de inicio 1 Julio 2019

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

UNIVERSITETET I OSLO
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Other (8)

Intoxication and Other Subjective Effects of Preoperative Opioids: A Randomized Controlled Trial

Autores: Siri Gurandsrud Karlsen, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Harald Lenz, Marlin Comelon, Silvana De Pirro, Chantal Berna, Eric L. Garland, Gernot Ernst, Siri Leknes, Marie Eikemo
Publicado en: Sneek Peek Preprint, 2025
Editor: CelPress, Elsevier

Minor role of endogenous opioids for acute pain regulation in humans: a systematic review and meta-analysis of placebo-controlled antagonist studies

Autores: Isabell M. Meier, Martin Trøstheim, Eira Nordeng Jensen, Mathias Nikolai Roland, Guro Engvig Løseth, Marie Eikemo, Siri Leknes
Publicado en: 2025
Editor: Center for Open Science
DOI: 10.31219/osf.io/bvfje_v1

Stress-enhanced opioid self-administration in healthy men: A randomized controlled experimental medicine study

Autores: Marie Eikemo, Guro Engvig Løseth, Molly Carlyle, Martin Trøstheim, Gernot Ernst, Claudia Pazmandi, Matthew Thompson, Cecilia Vezzani, Isabell M. Meier, Tom Johnstone, Markus Heilig, Guido Biele, and Siri Leknes
Publicado en: Preprint, 2024
Editor: n/a
DOI: 10.31219/osf.io/v8dxy

Endogenous Mu-Opioid Modulation of Social Connection in Humans: A Systematic Review and Meta-Analysis

Autores: Guro Engvig Løseth, Martin Trøstheim, and Siri Leknes
Publicado en: Preprint, 2023
Editor: n/a
DOI: 10.31234/osf.io/gha86

Justify your disability! A simulated medical evaluation as a robust novel stress induction paradigm in chronic pain patients

Autores: Aimie Chiron, Aurore Fernandez, Léa Schmidt, Sonia Plaza-Wüthrich, Marc R. Suter, Siri Leknes, Chantal Berna
Publicado en: bioRxiv The preprint server for biology, 2026
Editor: openRxiv
DOI: 10.1101/2024.07.03.601919

Experimental Pain Responses and Clinical Pain Symptoms in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Autores: Martin Trøstheim, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Publicado en: OSF Preprints, 2025
Editor: Center for Open Science
DOI: 10.31234/osf.io/9umb4_v1

Stress recovery with social support: A dyadic stress and support task

Autores: Guro Engvig Løseth, Marie Eikemo, Martin Trøstheim, Isabell M. Meier, Herman Bjørnstad, Anna Asratian, Claudia Pazmandi, Vegard Wathne Tangen, Markus Heilig, Siri Leknes
Publicado en: preprint, 2022
Editor: Open Science Framework

Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade

Autores: Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost, Siri Leknes
Publicado en: preprint, 2022
Editor: Open Science Framework
DOI: 10.1101/2022.02.25.481943

Peer reviewed articles (14)

Do endogenous opioids mediate or fine-tune human pain relief?

Autores: Marie Eikemo, Guro Løseth, Siri Leknes
Publicado en: PAIN, 2021, ISSN 0304-3959
Editor: Elsevier BV
DOI: 10.1097/j.pain.0000000000002286

Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology

Autores: Siri Leknes, Lauren Y. Atlas
Publicado en: British Journal of Anaesthesia, Edición 124/3, 2020, Página(s) e29-e33, ISSN 0007-0912
Editor: Oxford University Press
DOI: 10.1016/j.bja.2019.10.006

Opioid analgesic effects on subjective well‐being in the operating theatre*

Autores: M. Eikemo; I. M. Meier; G. E. Løseth; M. Trøstheim; N. Ørstavik; E. N. Jensen; E. L. Garland; C. Berna; G. Ernst; S. Leknes
Publicado en: Anaesthesia, Edición vol. 78, no. 9, 2023, Página(s) 1102-1111, ISSN 0003-2409
Editor: Blackwell Publishing Inc.
DOI: 10.1111/anae.16069

Stress recovery with social support: A dyadic stress and support task

Autores: Guro Engvig Løseth; Marie Eikemo; Martin Trøstheim; Isabell M. Meier; Herman Bjørnstad; Anna Asratian; Claudia Pazmandi; Vegard Wathne Tangen; Markus Heilig; Siri Leknes
Publicado en: Psychoneuroendocrinology, Edición 146, 2022, ISSN 0306-4530
Editor: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105949

Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis

Autores: Guro Løseth, Martin Trøstheim, Siri Leknes
Publicado en: Translational Psychiatry, Edición 14, 2024, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-024-03088-3

Assessment of Anhedonia in Adults With and Without Mental Illness

Autores: Martin Trøstheim, Marie Eikemo, Remy Meir, Ingelin Hansen, Elisabeth Paul, Sara Liane Kroll, Eric L. Garland, Siri Leknes
Publicado en: JAMA Network Open, Edición 3/8, 2020, Página(s) e2013233, ISSN 2574-3805
Editor: American Medical Association
DOI: 10.1001/jamanetworkopen.2020.13233

Factors associated with use of opioid rescue medication after surgery

Autores: Isabell M Meier; Marie Eikemo; Martin Trøstheim; Kaja Buen; Eira Jensen; Siri Gurandsrud Karlsen; Silje E Reme; Chantal Berna; Siri Leknes; Gernot Ernst
Publicado en: Regional Anesthesia & Pain Medicine, Edición 1, 2023, ISSN 1532-8651
Editor: American Society of Regional Anesthesia and Pain Medicine
DOI: 10.1136/rapm-2023-104412

Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery

Autores: Molly Carlyle, Malin Kvande, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo
Publicado en: Addiction Research Theory, Edición 32, 2024, Página(s) 46-57, ISSN 1606-6359
Editor: Brunner - Routledge (US)
DOI: 10.1080/16066359.2023.2211348

Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Autores: Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost & Siri Leknes
Publicado en: Neuropsychopharmacology, Edición 48, 2022, Página(s) 299-307, ISSN 1740-634X
Editor: Springer Nature
DOI: 10.1038/s41386-022-01416-z

Opioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction

Autores: Guro Løseth, Marie Eikemo, Siri Leknes
Publicado en: Biological Psychiatry, Edición 97, 2025, Página(s) 971-981, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2024.11.011

The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies

Autores: Isabell M. Meier, Marie Eikemo, Siri Leknes
Publicado en: Current Addiction Reports, Edición 3, 2021, Página(s) 306-318, ISSN 2196-2952
Editor: Springer Link
DOI: 10.1007/s40429-021-00366-8

Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men

Autores: Morgan Scarth, Lisa Evju Hauger, Per Medbøe Thorsby, Siri Leknes, Ingunn R Hullstein, Lars T. Westlye, Astrid Bjørnebekk
Publicado en: Psychopharmacology, Edición 241, 2024, Página(s) 701-715, ISSN 0033-3158
Editor: Springer Verlag
DOI: 10.1007/s00213-023-06497-2

Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers

Autores: Molly Carlyle, Harriet de Wit, Siri Leknes
Publicado en: Journal of Psychopharmacology, Edición 38, 2025, Página(s) 986-997, ISSN 0269-8811
Editor: SAGE Publications
DOI: 10.1177/02698811241268892

Reward Sensitivity in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Autores: Martin Trøstheim, Mads Lund Pedersen, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Philipp Paul Lobmaier, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Publicado en: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Edición 10, 2026, Página(s) 1166-1176, ISSN 2451-9022
Editor: Elsevier BV
DOI: 10.1016/j.bpsc.2025.04.013

Non-peer reviewed articles (1)

Understanding individual variability in opioid responses: A call to arms

Autores: Siri Leknes, Marie Eikemo, Guro Løseth
Publicado en: Addiction Biology, Edición 29, 2024, ISSN 1355-6215
Editor: Taylor & Francis
DOI: 10.1111/adb.13418