How distress alters opioid drug effects and abuse liability

Informazioni relative al progetto

OPIOIDREWARD

ID dell’accordo di sovvenzione: 802885

DOI

10.3030/802885

Progetto chiuso

Data della firma CE 26 Giugno 2019

Data di avvio 1 Luglio 2019

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

UNIVERSITETET I OSLO
Norway

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Other (8)

Intoxication and Other Subjective Effects of Preoperative Opioids: A Randomized Controlled Trial

Autori: Siri Gurandsrud Karlsen, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Harald Lenz, Marlin Comelon, Silvana De Pirro, Chantal Berna, Eric L. Garland, Gernot Ernst, Siri Leknes, Marie Eikemo
Pubblicato in: Sneek Peek Preprint, 2025
Editore: CelPress, Elsevier

Minor role of endogenous opioids for acute pain regulation in humans: a systematic review and meta-analysis of placebo-controlled antagonist studies

Autori: Isabell M. Meier, Martin Trøstheim, Eira Nordeng Jensen, Mathias Nikolai Roland, Guro Engvig Løseth, Marie Eikemo, Siri Leknes
Pubblicato in: 2025
Editore: Center for Open Science
DOI: 10.31219/osf.io/bvfje_v1

Stress-enhanced opioid self-administration in healthy men: A randomized controlled experimental medicine study

Autori: Marie Eikemo, Guro Engvig Løseth, Molly Carlyle, Martin Trøstheim, Gernot Ernst, Claudia Pazmandi, Matthew Thompson, Cecilia Vezzani, Isabell M. Meier, Tom Johnstone, Markus Heilig, Guido Biele, and Siri Leknes
Pubblicato in: Preprint, 2024
Editore: n/a
DOI: 10.31219/osf.io/v8dxy

Endogenous Mu-Opioid Modulation of Social Connection in Humans: A Systematic Review and Meta-Analysis

Autori: Guro Engvig Løseth, Martin Trøstheim, and Siri Leknes
Pubblicato in: Preprint, 2023
Editore: n/a
DOI: 10.31234/osf.io/gha86

Justify your disability! A simulated medical evaluation as a robust novel stress induction paradigm in chronic pain patients

Autori: Aimie Chiron, Aurore Fernandez, Léa Schmidt, Sonia Plaza-Wüthrich, Marc R. Suter, Siri Leknes, Chantal Berna
Pubblicato in: bioRxiv The preprint server for biology, 2026
Editore: openRxiv
DOI: 10.1101/2024.07.03.601919

Experimental Pain Responses and Clinical Pain Symptoms in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Autori: Martin Trøstheim, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Pubblicato in: OSF Preprints, 2025
Editore: Center for Open Science
DOI: 10.31234/osf.io/9umb4_v1

Stress recovery with social support: A dyadic stress and support task

Autori: Guro Engvig Løseth, Marie Eikemo, Martin Trøstheim, Isabell M. Meier, Herman Bjørnstad, Anna Asratian, Claudia Pazmandi, Vegard Wathne Tangen, Markus Heilig, Siri Leknes
Pubblicato in: preprint, 2022
Editore: Open Science Framework

Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade

Autori: Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost, Siri Leknes
Pubblicato in: preprint, 2022
Editore: Open Science Framework
DOI: 10.1101/2022.02.25.481943

Peer reviewed articles (14)

Do endogenous opioids mediate or fine-tune human pain relief?

Autori: Marie Eikemo, Guro Løseth, Siri Leknes
Pubblicato in: PAIN, 2021, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002286

Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology

Autori: Siri Leknes, Lauren Y. Atlas
Pubblicato in: British Journal of Anaesthesia, Numero 124/3, 2020, Pagina/e e29-e33, ISSN 0007-0912
Editore: Oxford University Press
DOI: 10.1016/j.bja.2019.10.006

Opioid analgesic effects on subjective well‐being in the operating theatre*

Autori: M. Eikemo; I. M. Meier; G. E. Løseth; M. Trøstheim; N. Ørstavik; E. N. Jensen; E. L. Garland; C. Berna; G. Ernst; S. Leknes
Pubblicato in: Anaesthesia, Numero vol. 78, no. 9, 2023, Pagina/e 1102-1111, ISSN 0003-2409
Editore: Blackwell Publishing Inc.
DOI: 10.1111/anae.16069

Stress recovery with social support: A dyadic stress and support task

Autori: Guro Engvig Løseth; Marie Eikemo; Martin Trøstheim; Isabell M. Meier; Herman Bjørnstad; Anna Asratian; Claudia Pazmandi; Vegard Wathne Tangen; Markus Heilig; Siri Leknes
Pubblicato in: Psychoneuroendocrinology, Numero 146, 2022, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105949

Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis

Autori: Guro Løseth, Martin Trøstheim, Siri Leknes
Pubblicato in: Translational Psychiatry, Numero 14, 2024, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-024-03088-3

Assessment of Anhedonia in Adults With and Without Mental Illness

Autori: Martin Trøstheim, Marie Eikemo, Remy Meir, Ingelin Hansen, Elisabeth Paul, Sara Liane Kroll, Eric L. Garland, Siri Leknes
Pubblicato in: JAMA Network Open, Numero 3/8, 2020, Pagina/e e2013233, ISSN 2574-3805
Editore: American Medical Association
DOI: 10.1001/jamanetworkopen.2020.13233

Factors associated with use of opioid rescue medication after surgery

Autori: Isabell M Meier; Marie Eikemo; Martin Trøstheim; Kaja Buen; Eira Jensen; Siri Gurandsrud Karlsen; Silje E Reme; Chantal Berna; Siri Leknes; Gernot Ernst
Pubblicato in: Regional Anesthesia & Pain Medicine, Numero 1, 2023, ISSN 1532-8651
Editore: American Society of Regional Anesthesia and Pain Medicine
DOI: 10.1136/rapm-2023-104412

Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery

Autori: Molly Carlyle, Malin Kvande, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo
Pubblicato in: Addiction Research Theory, Numero 32, 2024, Pagina/e 46-57, ISSN 1606-6359
Editore: Brunner - Routledge (US)
DOI: 10.1080/16066359.2023.2211348

Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Autori: Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost & Siri Leknes
Pubblicato in: Neuropsychopharmacology, Numero 48, 2022, Pagina/e 299-307, ISSN 1740-634X
Editore: Springer Nature
DOI: 10.1038/s41386-022-01416-z

Opioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction

Autori: Guro Løseth, Marie Eikemo, Siri Leknes
Pubblicato in: Biological Psychiatry, Numero 97, 2025, Pagina/e 971-981, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2024.11.011

The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies

Autori: Isabell M. Meier, Marie Eikemo, Siri Leknes
Pubblicato in: Current Addiction Reports, Numero 3, 2021, Pagina/e 306-318, ISSN 2196-2952
Editore: Springer Link
DOI: 10.1007/s40429-021-00366-8

Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men

Autori: Morgan Scarth, Lisa Evju Hauger, Per Medbøe Thorsby, Siri Leknes, Ingunn R Hullstein, Lars T. Westlye, Astrid Bjørnebekk
Pubblicato in: Psychopharmacology, Numero 241, 2024, Pagina/e 701-715, ISSN 0033-3158
Editore: Springer Verlag
DOI: 10.1007/s00213-023-06497-2

Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers

Autori: Molly Carlyle, Harriet de Wit, Siri Leknes
Pubblicato in: Journal of Psychopharmacology, Numero 38, 2025, Pagina/e 986-997, ISSN 0269-8811
Editore: SAGE Publications
DOI: 10.1177/02698811241268892

Reward Sensitivity in Patients Receiving Opioid Agonist and Antagonist Treatment for Opioid Use Disorder: An Observational Study

Autori: Martin Trøstheim, Mads Lund Pedersen, Siri Leknes, Lennja Majid Hama, Mathias Nikolai Roland, Philipp Paul Lobmaier, Kristin Klemmetsby Solli, Bente M. Weimand, Lars Tanum, Marie Eikemo
Pubblicato in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Numero 10, 2026, Pagina/e 1166-1176, ISSN 2451-9022
Editore: Elsevier BV
DOI: 10.1016/j.bpsc.2025.04.013

Non-peer reviewed articles (1)

Understanding individual variability in opioid responses: A call to arms

Autori: Siri Leknes, Marie Eikemo, Guro Løseth
Pubblicato in: Addiction Biology, Numero 29, 2024, ISSN 1355-6215
Editore: Taylor & Francis
DOI: 10.1111/adb.13418