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Great ape organoids to reconstruct uniquely human development

Project description

What sets us apart from our closest evolutionary relatives?

How are Neanderthals and modern humans different? What caused humans to diverge? What separates us from chimpanzees and other apes? Genome comparisons have identified genetic changes that likely contribute to innovations in human metabolic and cognitive physiology. The EU-funded ANTHROPOID project will use organoids to study the changes that set modern humans apart from our closest evolutionary relatives as well as all other organisms on the planet. It will create a great ape developmental cell atlas using cortex, liver and small intestine organoids. The research team will dissect enhancer evolution using single-cell genomic screens and ancestralise human cells to resurrect prehuman cellular phenotypes.

Host institution

F. HOFFMANN-LA ROCHE AG
Net EU contribution
€ 1 038 782,71
Address
Grenzacherstrasse 124
4070 Basel
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Beneficiaries (2)

F. HOFFMANN-LA ROCHE AG
Switzerland
Net EU contribution
€ 1 038 782,71
Address
Grenzacherstrasse 124
4070 Basel

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL

Participation ended

Switzerland
Net EU contribution
€ 461 217,29
Address
C/o Universitätsspital Basel, Augenklinik, Mittlere Strasse
4056 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00