Great ape organoids to reconstruct uniquely human development

Project Information

ANTHROPOID

Grant agreement ID: 803441

DOI

10.3030/803441

Project closed

EC signature date 3 May 2019

Start date 1 June 2019

End date 31 May 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

F. HOFFMANN-LA ROCHE AG
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

CSS: cluster similarity spectrum integration of single-cell genomics data

Author(s): Zhisong He, Agnieska Brazovskaja, Sebastian Ebert, J. Gray Camp, Barbara Treutlein
Published in: Genome Biology, Issue 21/1, 2020, Page(s) 224-244, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/s13059-020-02147-4

Cell atlas of the regenerating human liver after portal vein embolization

Author(s): Agnieska Brazovskaja, Tomás Gomes, Rene Holtackers, Philipp Wahle, Christiane Körner, Zhisong He, Theresa Schaffer, Julian Connor Eckel, René Hänsel, Malgorzata Santel, Makiko Seimiya, Timm Denecke, Michael Dannemann, Mario Brosch, Jochen Hampe, Daniel Seehofer, Georg Damm, J. Gray Camp, Barbara Treutlein
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49236-7

Morphodynamics of human early brain organoid development

Author(s): Akanksha Jain, Gilles Gut, Fátima Sanchis-Calleja, Reto Tschannen, Zhisong He, Nicolas Luginbühl, Fides Zenk, Antonius Chrisnandy, Simon Streib, Christoph Harmel, Ryoko Okamoto, Malgorzata Santel, Makiko Seimiya, René Holtackers, Juliane K. Rohland, Sophie Martina Johanna Jansen, Matthias P. Lutolf, J. Gray Camp, Barbara Treutlein
Published in: Nature, Issue 644, 2025, Page(s) 1010-1019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09151-3

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

Author(s): Jonas Simon Fleck, Fátima Sanchís-Calleja, Zhisong He, Malgorzata Santel, Michael James Boyle, J. Gray Camp, Barbara Treutlein
Published in: Cell Stem Cell, Issue 28, 2021, Page(s) 1-12, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.02.015

Charting human development using a multi-endodermal organ atlas and organoid models

Author(s): Qianhui Yu, Umut Kilik, Emily M. Holloway, Yu-Hwai Tsai, Christoph Harmel, Angeline Wu, Joshua H. Wu, Michael Czerwinski, Charlie J. Childs, Zhisong He, Meghan M. Capeling, Sha Huang, Ian A. Glass, Peter D.R. Higgins, Barbara Treutlein, Jason R. Spence, J. Gray Camp
Published in: Cell, Issue 184, 2021, Page(s) 1-18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.04.028

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Author(s): Quan Xu, Lennard Halle, Soroor Hediyeh-zadeh, Merel Kuijs, Rya Riedweg, Umut Kilik, Timothy Recaldin, Qianhui Yu, Isabell Rall, Tristan Frum, Lukas Adam, Shrey Parikh, Raphael Kfuri-Rubens, Manuel Gander, Dominik Klein, Fabiola Curion, Zhisong He, Jonas Simon Fleck, Koen Oost, Maurice Kahnwald, Silvia Barbiero, Olga Mitrofanova, Grzegorz Jerzy Maciag, Kim B. Jensen, Matthias Lutolf, Prisca Liberal
Published in: Nature Genetics, Issue 57, 2025, Page(s) 1201-1212, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02182-6

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Author(s): Fides Zenk, Jonas Simon Fleck, Sophie Martina Johanna Jansen, Bijan Kashanian, Benedikt Eisinger, Małgorzata Santel, Jean-Samuel Dupré, J. Gray Camp, Barbara Treutlein
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 1376-1386, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01652-0

Inferring and perturbing cell fate regulomes in human brain organoids

Author(s): Jonas Simon Fleck, Sophie Martina Johanna Jansen, Damian Wollny, Fides Zenk, Makiko Seimiya, Akanksha Jain, Ryoko Okamoto, Malgorzata Santel, Zhisong He, J. Gray Camp, Barbara Treutlein
Published in: Nature, Issue 621, 2023, Page(s) 365-372, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05279-8

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model

Author(s): Yu-Han Hung, Sha Huang, Michael K Dame, Qianhui Yu, Qing C Yu, Yi A Zeng, J Gray Camp, Jason R Spence, Praveen Sethupathy
Published in: Nucleic Acids Research, Issue 49/2, 2021, Page(s) 726-744, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1204

Recent evolution of the developing human intestine affects metabolic and barrier functions

Author(s): Qianhui Yu, Umut Kilik, Stefano Secchia, Lukas Adam, Yu-Hwai Tsai, Christiana Fauci, Jasper Janssens, Charlie J. Childs, Katherine D. Walton, Rubén López-Sandoval, Angeline Wu, Marina Almató Bellavista, Sha Huang, Calen A. Steiner, Yannick Throm, Michael James Boyle, Zhisong He, Joep Beumer, Barbara Treutlein, Craig B. Lowe, Jason R. Spence, J. Gray Camp
Published in: Science, Issue 389, 2025, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adr8628

Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics

Author(s): Giovanna Brancati, Barbara Treutlein, J. Gray Camp
Published in: Neuron, Issue 107/6, 2020, Page(s) 1000-1013, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.09.001

Lineage recording in human cerebral organoids

Author(s): Zhisong He, Ashley Maynard, Akanksha Jain, Tobias Gerber, Rebecca Petri, Hsiu-Chuan Lin, Malgorzata Santel, Kevin Ly, Jean-Samuel Dupré, Leila Sidow, Fatima Sanchis Calleja, Sophie M. J. Jansen, Stephan Riesenberg, J. Gray Camp, Barbara Treutlein
Published in: Nature Methods, 2021, Page(s) 90-99, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01344-8

Mapping human cell phenotypes to genotypes with single-cell genomics

Author(s): J. Gray Camp, Randall Platt, Barbara Treutlein
Published in: Science, Issue 365/6460, 2019, Page(s) 1401-1405, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax6648

Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions

Author(s): Michael Dannemann, Zhisong He, Christian Heide, Benjamin Vernot, Leila Sidow, Sabina Kanton, Anne Weigert, Barbara Treutlein, Svante Pääbo, Janet Kelso, J. Gray Camp
Published in: Stem Cell Reports, Issue 15/1, 2020, Page(s) 214-225, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.05.018

An integrated transcriptomic cell atlas of human neural organoids

Author(s): Zhisong He, Leander Dony, Jonas Simon Fleck, Artur Szałata, Katelyn X. Li, Irena Slišković, Hsiu-Chuan Lin, Malgorzata Santel, Alexander Atamian, Giorgia Quadrato, Jieran Sun, Sergiu P. Pașca, null null, Neal D. Amin, Kevin W. Kelley, Taylor Bertucci, Sally Temple, Kathryn R. Bowles, Nicolò Caporale, Emanuele Villa, Giuseppe Testa, Cristiana Cruceanu, Elisabeth B. Binder, J. Gray Camp, Fabian
Published in: Nature, Issue 635, 2024, Page(s) 690-698, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08172-8

Organoid single-cell genomic atlas uncovers human-specific features of brain development

Author(s): Sabina Kanton, Michael James Boyle, Zhisong He, Malgorzata Santel, Anne Weigert, Fátima Sanchís-Calleja, Patricia Guijarro, Leila Sidow, Jonas Simon Fleck, Dingding Han, Zhengzong Qian, Michael Heide, Wieland B. Huttner, Philipp Khaitovich, Svante Pääbo, Barbara Treutlein, J. Gray Camp
Published in: Nature, Issue 574/7778, 2019, Page(s) 418-422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1654-9

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

Author(s): Alex A. Pollen, Umut Kilik, Craig B. Lowe, J. Gray Camp
Published in: Nature Reviews Genetics, Issue 24, 2024, Page(s) 687-711, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-022-00568-4

Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

Author(s): Nico Schramma; Cristina Loureiro; Tobias Gerber; Siyu Chen; Akanksha Jain; Anne Weber; Anne Weigert; Malgorzata Santel; Karen Alim; Barbara Treutlein; J Gray Camp
Published in: eLife, Issue 1, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.3929/ethz-b-000535011

Book chapters (1)

Single-cell genomic analysis of human cerebral organoids

Author(s): Sabina Kanton, Barbara Treutlein, J. Gray Camp
Published in: Human Pluripotent Stem Cell Derived Organoid Models, Issue 159, 2020, Page(s) 229-256, ISBN 9780128215319
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2020.03.013