Defining heterocellular signalling within the intratumoral stem cell niche of colorectal cancer

Project Information

IntratumoralNiche

Grant agreement ID: 803608

DOI 10.3030/803608

Project closed

EC signature date 25 October 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Publications

Non-peer reviewed articles (2)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Author(s): Arianna Fumagalli, Koen C. Oost, Lennart Kester, Jessica Morgner, Laura Bornes, Lotte Bruens, Lisa Spaargaren, Maria Azkanaz, Tim Schelfhorst, Evelyne Beerling, Maria C. Heinz, Daniel Postrach, Danielle Seinstra, Anieta M. Sieuwerts, John W.M. Martens, Stefan van der Elst, Martijn van Baalen, Debajit Bhowmick, Nienke Vrisekoop, Saskia I.J. Ellenbroek, Saskia J.E. Suijkerbuijk, Hugo J. Snippert, Ja
Published in: Cell Stem Cell, Issue 26/4, 2020, Page(s) 569-578.e7, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.02.008

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Author(s): Ana C. F. Bolhaqueiro, Bas Ponsioen, Bjorn Bakker, Sjoerd J. Klaasen, Emre Kucukkose, Richard H. van Jaarsveld, Judith Vivié, Ingrid Verlaan-Klink, Nizar Hami, Diana C. J. Spierings, Nobuo Sasaki, Devanjali Dutta, Sylvia F. Boj, Robert G. J. Vries, Peter M. Lansdorp, Marc van de Wetering, Alexander van Oudenaarden, Hans Clevers, Onno Kranenburg, Floris Foijer, Hugo J. G. Snippert, Geert J. P. L.
Published in: Nature Genetics, Issue 51/5, 2019, Page(s) 824-834, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0399-6

Peer reviewed articles (6)

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Author(s): Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie, Dimitrios Laskaris, Ravian L. van Ineveld, Simone Kersten, Andrea Bertotti, Francesco Sassi, François Sipieter, Benjamin Cappe, Sander Mertens, Ingrid Verlaan-Klink, Sylvia F. Boj, Rob G. J. Vries, Holger Rehmann, Peter Vandenabeele, Franck B. Riquet, Livio Trusolino, Johannes L. Bos, Hugo J. G. Snippert
Published in: Nature Cell Biology, Issue 23/4, 2021, Page(s) 377-390, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

Intestinal Regeneration: Regulation by the Microenvironment

Author(s): Joris H. Hageman, Maria C. Heinz, Kai Kretzschmar, Jelte van der Vaart, Hans Clevers, Hugo J.G. Snippert
Published in: Developmental Cell, Issue 54/4, 2020, Page(s) 435-446, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.07.009

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Author(s): Yannik Bollen; Joris H. Hageman; Petra van Leenen; Lucca L. M. Derks; Bas Ponsioen; Julian R. Buissant des Amorie; Ingrid Verlaan-Klink; Myrna van den Bos; Leon W. M. M. Terstappen; Ruben van Boxtel; Hugo J. G. Snippert
Published in: PLOS BIOLOGY, Issue 1, 2022, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001527

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Author(s): Sander Mertens, Maarten A Huismans, Carla S Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F Boj, Hans Clevers, Jeanine M L Roodhart, Johannes L Bos, Hugo J G Snippert
Published in: Cell Reports, Issue 42(4), 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112324

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Author(s): Maria C. Heinz; Niek A. Peters; Koen C. Oost; Rik G.H. Lindeboom; Lisa van Voorthuijsen; Arianna Fumagalli; Mirjam C. van der Net; Gustavo de Medeiros; Joris H. Hageman; Ingrid Verlaan-Klink; Inne H.M. Borel Rinkes; Prisca Liberali; Martijn Gloerich; Jacco van Rheenen; Michiel Vermeulen; Onno Kranenburg; Hugo J.G. Snippert
Published in: Cancer Research, 2022, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-21-0933

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Author(s): Yannik Bollen, Ellen Stelloo, Petra van Leenen, Myrna van den Bos, Bas Ponsioen, Bingxin Lu, Markus J. van Roosmalen, Ana C. F. Bolhaqueiro, Christopher Kimberley, Maximilian Mossner, William C. H. Cross, Nicolle J. M. Besselink, Bastiaan van der Roest, Sander Boymans, Koen C. Oost, Sippe G. de Vries, Holger Rehmann, Edwin Cuppen, Susanne M. A. Lens, Geert J. P. L. Kops, Wigard P. Kloosterman, Leo
Published in: Nature Genetics, Issue 53/8, 2021, Page(s) 1187-1195, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00891-2