Defining heterocellular signalling within the intratumoral stem cell niche of colorectal cancer

Informazioni relative al progetto

IntratumoralNiche

ID dell’accordo di sovvenzione: 803608

DOI 10.3030/803608

Progetto chiuso

Data della firma CE 25 Ottobre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Pubblicazioni

Non-peer reviewed articles (2)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Autori: Arianna Fumagalli, Koen C. Oost, Lennart Kester, Jessica Morgner, Laura Bornes, Lotte Bruens, Lisa Spaargaren, Maria Azkanaz, Tim Schelfhorst, Evelyne Beerling, Maria C. Heinz, Daniel Postrach, Danielle Seinstra, Anieta M. Sieuwerts, John W.M. Martens, Stefan van der Elst, Martijn van Baalen, Debajit Bhowmick, Nienke Vrisekoop, Saskia I.J. Ellenbroek, Saskia J.E. Suijkerbuijk, Hugo J. Snippert, Ja
Pubblicato in: Cell Stem Cell, Numero 26/4, 2020, Pagina/e 569-578.e7, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2020.02.008

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Autori: Ana C. F. Bolhaqueiro, Bas Ponsioen, Bjorn Bakker, Sjoerd J. Klaasen, Emre Kucukkose, Richard H. van Jaarsveld, Judith Vivié, Ingrid Verlaan-Klink, Nizar Hami, Diana C. J. Spierings, Nobuo Sasaki, Devanjali Dutta, Sylvia F. Boj, Robert G. J. Vries, Peter M. Lansdorp, Marc van de Wetering, Alexander van Oudenaarden, Hans Clevers, Onno Kranenburg, Floris Foijer, Hugo J. G. Snippert, Geert J. P. L.
Pubblicato in: Nature Genetics, Numero 51/5, 2019, Pagina/e 824-834, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0399-6

Peer reviewed articles (6)

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Autori: Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie, Dimitrios Laskaris, Ravian L. van Ineveld, Simone Kersten, Andrea Bertotti, Francesco Sassi, François Sipieter, Benjamin Cappe, Sander Mertens, Ingrid Verlaan-Klink, Sylvia F. Boj, Rob G. J. Vries, Holger Rehmann, Peter Vandenabeele, Franck B. Riquet, Livio Trusolino, Johannes L. Bos, Hugo J. G. Snippert
Pubblicato in: Nature Cell Biology, Numero 23/4, 2021, Pagina/e 377-390, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

Intestinal Regeneration: Regulation by the Microenvironment

Autori: Joris H. Hageman, Maria C. Heinz, Kai Kretzschmar, Jelte van der Vaart, Hans Clevers, Hugo J.G. Snippert
Pubblicato in: Developmental Cell, Numero 54/4, 2020, Pagina/e 435-446, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2020.07.009

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Autori: Yannik Bollen; Joris H. Hageman; Petra van Leenen; Lucca L. M. Derks; Bas Ponsioen; Julian R. Buissant des Amorie; Ingrid Verlaan-Klink; Myrna van den Bos; Leon W. M. M. Terstappen; Ruben van Boxtel; Hugo J. G. Snippert
Pubblicato in: PLOS BIOLOGY, Numero 1, 2022, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001527

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Autori: Sander Mertens, Maarten A Huismans, Carla S Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F Boj, Hans Clevers, Jeanine M L Roodhart, Johannes L Bos, Hugo J G Snippert
Pubblicato in: Cell Reports, Numero 42(4), 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112324

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Autori: Maria C. Heinz; Niek A. Peters; Koen C. Oost; Rik G.H. Lindeboom; Lisa van Voorthuijsen; Arianna Fumagalli; Mirjam C. van der Net; Gustavo de Medeiros; Joris H. Hageman; Ingrid Verlaan-Klink; Inne H.M. Borel Rinkes; Prisca Liberali; Martijn Gloerich; Jacco van Rheenen; Michiel Vermeulen; Onno Kranenburg; Hugo J.G. Snippert
Pubblicato in: Cancer Research, 2022, ISSN 1538-7445
Editore: AACR
DOI: 10.1158/0008-5472.can-21-0933

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Autori: Yannik Bollen, Ellen Stelloo, Petra van Leenen, Myrna van den Bos, Bas Ponsioen, Bingxin Lu, Markus J. van Roosmalen, Ana C. F. Bolhaqueiro, Christopher Kimberley, Maximilian Mossner, William C. H. Cross, Nicolle J. M. Besselink, Bastiaan van der Roest, Sander Boymans, Koen C. Oost, Sippe G. de Vries, Holger Rehmann, Edwin Cuppen, Susanne M. A. Lens, Geert J. P. L. Kops, Wigard P. Kloosterman, Leo
Pubblicato in: Nature Genetics, Numero 53/8, 2021, Pagina/e 1187-1195, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-021-00891-2