Defining heterocellular signalling within the intratumoral stem cell niche of colorectal cancer

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Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Autorzy: Arianna Fumagalli, Koen C. Oost, Lennart Kester, Jessica Morgner, Laura Bornes, Lotte Bruens, Lisa Spaargaren, Maria Azkanaz, Tim Schelfhorst, Evelyne Beerling, Maria C. Heinz, Daniel Postrach, Danielle Seinstra, Anieta M. Sieuwerts, John W.M. Martens, Stefan van der Elst, Martijn van Baalen, Debajit Bhowmick, Nienke Vrisekoop, Saskia I.J. Ellenbroek, Saskia J.E. Suijkerbuijk, Hugo J. Snippert, Ja
Opublikowane w: Cell Stem Cell, Numer 26/4, 2020, Strona(/y) 569-578.e7, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2020.02.008

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Autorzy: Ana C. F. Bolhaqueiro, Bas Ponsioen, Bjorn Bakker, Sjoerd J. Klaasen, Emre Kucukkose, Richard H. van Jaarsveld, Judith Vivié, Ingrid Verlaan-Klink, Nizar Hami, Diana C. J. Spierings, Nobuo Sasaki, Devanjali Dutta, Sylvia F. Boj, Robert G. J. Vries, Peter M. Lansdorp, Marc van de Wetering, Alexander van Oudenaarden, Hans Clevers, Onno Kranenburg, Floris Foijer, Hugo J. G. Snippert, Geert J. P. L.
Opublikowane w: Nature Genetics, Numer 51/5, 2019, Strona(/y) 824-834, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-019-0399-6

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Autorzy: Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie, Dimitrios Laskaris, Ravian L. van Ineveld, Simone Kersten, Andrea Bertotti, Francesco Sassi, François Sipieter, Benjamin Cappe, Sander Mertens, Ingrid Verlaan-Klink, Sylvia F. Boj, Rob G. J. Vries, Holger Rehmann, Peter Vandenabeele, Franck B. Riquet, Livio Trusolino, Johannes L. Bos, Hugo J. G. Snippert
Opublikowane w: Nature Cell Biology, Numer 23/4, 2021, Strona(/y) 377-390, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

Intestinal Regeneration: Regulation by the Microenvironment

Autorzy: Joris H. Hageman, Maria C. Heinz, Kai Kretzschmar, Jelte van der Vaart, Hans Clevers, Hugo J.G. Snippert
Opublikowane w: Developmental Cell, Numer 54/4, 2020, Strona(/y) 435-446, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2020.07.009

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Autorzy: Yannik Bollen; Joris H. Hageman; Petra van Leenen; Lucca L. M. Derks; Bas Ponsioen; Julian R. Buissant des Amorie; Ingrid Verlaan-Klink; Myrna van den Bos; Leon W. M. M. Terstappen; Ruben van Boxtel; Hugo J. G. Snippert
Opublikowane w: PLOS BIOLOGY, Numer 1, 2022, ISSN 1544-9173
Wydawca: Public Library of Science
DOI: 10.1371/journal.pbio.3001527

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Autorzy: Sander Mertens, Maarten A Huismans, Carla S Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F Boj, Hans Clevers, Jeanine M L Roodhart, Johannes L Bos, Hugo J G Snippert
Opublikowane w: Cell Reports, Numer 42(4), 2023, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2023.112324

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Autorzy: Maria C. Heinz; Niek A. Peters; Koen C. Oost; Rik G.H. Lindeboom; Lisa van Voorthuijsen; Arianna Fumagalli; Mirjam C. van der Net; Gustavo de Medeiros; Joris H. Hageman; Ingrid Verlaan-Klink; Inne H.M. Borel Rinkes; Prisca Liberali; Martijn Gloerich; Jacco van Rheenen; Michiel Vermeulen; Onno Kranenburg; Hugo J.G. Snippert
Opublikowane w: Cancer Research, 2022, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/0008-5472.can-21-0933

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Autorzy: Yannik Bollen, Ellen Stelloo, Petra van Leenen, Myrna van den Bos, Bas Ponsioen, Bingxin Lu, Markus J. van Roosmalen, Ana C. F. Bolhaqueiro, Christopher Kimberley, Maximilian Mossner, William C. H. Cross, Nicolle J. M. Besselink, Bastiaan van der Roest, Sander Boymans, Koen C. Oost, Sippe G. de Vries, Holger Rehmann, Edwin Cuppen, Susanne M. A. Lens, Geert J. P. L. Kops, Wigard P. Kloosterman, Leo
Opublikowane w: Nature Genetics, Numer 53/8, 2021, Strona(/y) 1187-1195, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-021-00891-2

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