The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Project Information

Epilepsy_Core

Grant agreement ID: 803880

DOI

10.3030/803880

Project closed

EC signature date 15 February 2019

Start date 1 March 2019

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (35)

Machine learning for (non–)epileptic tissue detection from the intraoperative electrocorticogram

Author(s): Sem Hoogteijling, Eline V. Schaft, Evi H.M. Dirks, Sven Straumann, Matteo Demuru, Pieter van Eijsden, Tineke Gebbink, Willem M. Otte, Geertjan M. Huiskamp, Maryse A. van ’t Klooster, Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 167, 2025, Page(s) 14-25, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2024.08.012

HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy

Author(s): Julia Jacobs, Maeike Zijlmans
Published in: Epilepsy Currents, Issue 20, 2025, Page(s) 338-347, ISSN 1535-7597
Publisher: American Epilepsy Society
DOI: 10.1177/1535759720957308

Implementing intraoperative high‐density electrocorticography during epilepsy surgery

Author(s): Eline V. Schaft, Dongqing Sun, Sem Hoogteijling, Ziyi Wang, Frans S. S. Leijten, Pieter van Eijsden, Nick F. Ramsey, Pierre Robe, Maryse A. van 't Klooster, Maeike Zijlmans, null null
Published in: Epilepsia, Issue 66, 2025, Page(s) 1447-1461, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.18302

High-frequency oscillations in scalp EEG: A systematic review of methodological choices and clinical findings

Author(s): Lotte Noorlag, Nicole E.C. van Klink, Katsuhiro Kobayashi, Jean Gotman, Kees P.J. Braun, Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 137, 2025, Page(s) 46-58, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.12.017

High frequency oscillations associate with neuroinflammation in low-grade epilepsy associated tumors

Author(s): Dongqing Sun, Nicole E.C. van Klink, Anika Bongaarts, Willemiek E.J.M. Zweiphenning, Maryse A van 't Klooster, Tineke A Gebbink, Tom J Snijders, Pieter van Eijsden, Pierre A.J.T. Robe, Eleonora Aronica, Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 133, 2025, Page(s) 165-174, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.08.025

Structural and effective brain connectivity in focal epilepsy

Author(s): S.B. Jelsma, M. Zijlmans, I.B. Heijink, F.W.A. Hoefnagels, M. Raemaekers, W.M. Otte, N.E.C. van Klink, D. van Blooijs
Published in: NeuroImage: Reports, Issue 5, 2025, Page(s) 100274, ISSN 2666-9560
Publisher: Elsevier BV
DOI: 10.1016/j.ynirp.2025.100274

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial

Author(s): Willemiek Zweiphenning, Maryse A van 't Klooster, Nicole E C van Klink, Frans S S Leijten, Cyrille H Ferrier, Tineke Gebbink, Geertjan Huiskamp, Martine J E van Zandvoort, Monique M J van Schooneveld, M Bourez, Sophie Goemans, Sven Straumann, Peter C van Rijen, Peter H Gosselaar, Pieter van Eijsden, Willem M Otte, Eric van Diessen, Kees P J Braun, Maeike Zijlmans, Eltje M. Bloemen-Carlier, Veronik
Published in: The Lancet Neurology, Issue 21, 2025, Page(s) 982-993, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00311-8

Signaalkarakteristieken in mensen met een focale corticale dysplasie

Author(s): Eline Schaft, Maryse Van 't Klooster, Maeike Zijlmans
Published in: Epilepsie, periodiek voor professionals, Issue 21, 2022, Page(s) 13-15, ISSN 1571-0408
Publisher: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.12874

A Practical Workflow for Organizing Clinical Intraoperative and Long-term iEEG Data in BIDS

Author(s): Matteo Demuru, Dorien van Blooijs, Willemiek Zweiphenning, Dora Hermes, Frans Leijten, Maeike Zijlmans, null null
Published in: Neuroinformatics, Issue 20, 2022, Page(s) 727-736, ISSN 1539-2791
Publisher: Humana Press, Inc.
DOI: 10.1007/s12021-022-09567-6

Editorial: high-frequency oscillations in the hippocampus as biomarkers of pathology and healthy brain function

Author(s): Johannes Sarnthein, Julia Jacobs, Maeike Zijlmans
Published in: Frontiers in Human Neurosience, 2021, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnhum.2021.763881

The resolution revolution: Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient.

Author(s): Willemiek Zweiphenning; Eric van Diessen; Erik J. Aarnoutse; Frans S. S. Leijten; Peter C. van Rijen; Kees P.J. Braun; Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 1, 2020, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2020.02.006

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Author(s): Ziyi Wang, Jiaojiao Guo, Maryse van 't Klooster, Sem Hoogteijling, Julia Jacobs, Maeike Zijlmans
Published in: Neurology, Issue 102, 2024, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000209216

Super-resolution for localizing electrode grids as small, deformable objects during epilepsy surgery using augmented reality headsets

Author(s): Hizirwan S. Salim, Abdullah Thabit, Sem Hoogteijling, Maryse A. van ’t Klooster, Theo van Walsum, Maeike Zijlmans, Mohamed Benmahdjoub
Published in: International Journal of Computer Assisted Radiology and Surgery, Issue 20, 2025, Page(s) 2319-2327, ISSN 1861-6429
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11548-025-03401-5

Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations

Author(s): Vasileios Dimakopoulos, Jean Gotman, Petr Klimes, Nicolas von Ellenrieder, Shi Bei Tan, Garnett Smith, Stephen V Gliske, Margarita Maltseva, Minette Krisel Manalo, Martin Pail, Milan Brazdil, Dorien van Blooijs, Maryse A van ‘t Klooster, Sarah Johnson, Samantha Laboy, Debora Ledergerber, Lukas Imbach, Christos Papadelis, Michael R Sperling, Maeike Zijlmans, Jan Cimbalnik, Julia Jacobs, William C
Published in: Brain, Issue 148, 2025, Page(s) 1769-1777, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awae361

Intraoperative mapping of epileptogenic foci and tumor infiltration in neuro-oncology patients with epilepsy

Author(s): Dongqing Sun, Eline V Schaft, Bibi M van Stempvoort, Tineke A Gebbink, Maryse van ‘t Klooster, Pieter van Eijsden, Sandra M A van der Salm, Jan Willem Dankbaar, Maeike Zijlmans, Pierre A Robe
Published in: Neuro-Oncology Advances, Issue 6, 2024, ISSN 2632-2498
Publisher: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae125

High frequency oscillations relate to cognitive improvement after epilepsy surgery in children

Author(s): Dongqing Sun; Maryse A. van 't Klooster; Monique M.J. van Schooneveld; Willemiek Zweiphenning; Nicole van Klink; Cyrille H. Ferrier; Peter H. Gosselaar; Kees P.J. Braun; Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 1, 2020, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2020.01.019

The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Author(s): Sven Straumann, Eline Schaft, Herke Jan Noordmans, Jan Willem Dankbaar, Willem M Otte, Josee van Steenis, Paul Smits, Willemiek Zweiphenning, Pieter van Eijsden, Tineke Gebbink, Luigi Mariani, Maryse A van’t Klooster, Maeike Zijlmans
Published in: Brain Communications, Issue 4, 2023, ISSN 2632-1297
Publisher: Oxford University Press (OUP)
DOI: 10.1093/braincomms/fcac302

Seizure Outcome After Intraoperative Electrocorticography-Tailored Epilepsy Surgery

Author(s): Jiaojiao Guo, Ziyi Wang, Maryse A. van 't Klooster, Sandra M. Van Der Salm, Frans S. Leijten, Kees P. Braun, Maeike Zijlmans
Published in: Neurology, Issue 102, 2024, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000209430

Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?

Author(s): Alessandra Maccabeo, Maryse A. van 't Klooster, Eline Schaft, Matteo Demuru, Willemiek Zweiphenning, Peter Gosselaar, Tineke Gebbink, Wim M. Otte, Maeike Zijlmans
Published in: Frontiers in Neurology, Issue 13, 2022, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.797075

Potential merits and flaws of large language models in epilepsy care: A critical review

Author(s): Eric van Diessen, Ramon A. van Amerongen, Maeike Zijlmans, Willem M. Otte
Published in: Epilepsia, Issue 65, 2024, Page(s) 873-886, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.17907

Learn how to interpret and use intracranial <scp>EEG</scp> findings

Author(s): B. Frauscher, D. Mansilla, C. Abdallah, A. Astner‐Rohracher, S. Beniczky, M. Brazdil, V. Gnatkovsky, J. Jacobs, G. Kalamangalam, P. Perucca, P. Ryvlin, S. Schuele, J. Tao, Y. Wang, M. Zijlmans, A. McGonigal
Published in: Epileptic Disorders, Issue 26, 2024, Page(s) 1-59, ISSN 1294-9361
Publisher: John Libbey Eurotext
DOI: 10.1002/epd2.20190

HFO-trial: resultaten van een Randomised Controlled Trial in epilepsiechirurgie

Author(s): Maryse van ‘t Klooster, Willemiek Zweiphenning, Maeike Zijlmans
Published in: Epilepsie, periodiek voor professionals, Issue 21, 2022, Page(s) 11-12, ISSN 1571-0408
Publisher: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.12873

Are HFOs in the intraoperative ECoG related to hippocampal clerosis, vlume and IQ?

Author(s): Paula Agudelo Valencia, Nicole EC van Klink, Maryse A van 't Klooster, Willemiek JEM Zweiphenning, Banu Swampillai, Pieter van Eijsden, Tineke Gebbink, MArtine JE van Zandvoort, Maeike Zijlmans
Published in: Frontiers in Neurology, 2021, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.645925

Nasopharyngeal electrodes for recording mesiotemporal spikes: Post-covid revival?

Author(s): Maeike Zijlmans, Sandra van der Salm, Maryse van 't Klooster
Published in: Clinical Neurophysiology, 2021, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.04.004

Do acute postoperative seizures predict epilepsy surgery outcome? a scoping review

Author(s): Sebastiaan E. A. van Maanen, Maeike J. M. Zijlmans, Pieter van Eijsden, Sandra M. A. van der Salm
Published in: Acta Neurochirurgica, Issue 167, 2025, ISSN 0942-0940
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00701-025-06486-8

Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery?

Author(s): Nicole EC van Klink, Willemiek JEM Zweiphenning, Cyrille H Ferrier, Peter H Gosselaar, Kai J Miller, Eleonora Aronica, Kees PJ Braun, Maeike Zijlmans
Published in: Epilepsia, 2021, ISSN 1528-1167
Publisher: Wiley
DOI: 10.1111/epi.16845

Spatial and temporal properties of intra-operatively recorded spikes and high frequency oscillations in focal cortical dysplasia

Author(s): Eline V. Schaft, Dongqing Sun, Maryse A. van 't Klooster, Dorien van Blooijs, Paul L. Smits, Willemiek J.E.M. Zweiphenning, Peter H. Gosselaar, Cyrille H. Ferrier, Maeike Zijlmans
Published in: Clinical Neurophysiology, Issue 162, 2024, Page(s) 210-218, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2024.03.038

Intra-operatieve elektrocorticografie bij tumorgerelateerde epilepsie

Author(s): Sem Hoogteijling, Dongqing Sun
Published in: Epilepsie, periodiek voor professionals, Issue 19, 2021, Page(s) 11-13, ISSN 1571-0408
Publisher: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.11398

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Author(s): Matteo Demuru, Willemiek Zweiphenning, Dorien van Blooijs, Pieter Van Eijsden, Frans Leijten, Maeike Zijlmans, Stiliyan Kalitzin
Published in: Journal of Neural Engineering, 2020, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/abc3a8

Robust compression and detection of epileptiform patterns in ECoG using a real-time spiking neural network hardware framework

Author(s): Filippo Costa, Eline V. Schaft, Geertjan Huiskamp, Erik J. Aarnoutse, Maryse A. van’t Klooster, Niklaus Krayenbühl, Georgia Ramantani, Maeike Zijlmans, Giacomo Indiveri, Johannes Sarnthein
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47495-y

Deep learning for epileptogenic zone delineation from the invasive EEG: challenges and lookouts

Author(s): Sem Hoogteijling, Maeike Zijlmans
Published in: Brain Communications, Issue 4, 2022, ISSN 2632-1297
Publisher: Oxford University Press (OUP)
DOI: 10.1093/braincomms/fcab307

The optimal montage to mark interictal epileptiform discharges and high-frequency oscillations in intraoperative electrocorticography

Author(s): Ziyi Wang, Jiaojiao Guo, Eline Schaft, Sem Hoogteijling, Cyrille H. Ferrier, Gerhard H. Visser, Dongqing Sun, Friso Hoefnagels, Taku Inada, Sandra van der Salm, Geertjan Huiskamp, Nicole van Klink, Maryse van’t Klooster, Maeike Zijlmans
Published in: Clinical Neurophysiology Practice, Issue 10, 2025, Page(s) 246-255, ISSN 2467-981X
Publisher: Elsevier BV
DOI: 10.1016/j.cnp.2025.06.007

Clinical characteristics and diagnoses of 1213 children referred to a first seizure clinic

Author(s): Geertruida Slinger, Lotte Noorlag, Eric van Diessen, Willem M. Otte, Maeike Zijlmans, Floor E. Jansen, Kees P. J. Braun
Published in: Epilepsia Open, Issue 9, 2025, Page(s) 548-557, ISSN 2470-9239
Publisher: Wiley
DOI: 10.1002/epi4.12883

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.

Author(s): Matteo Demuru; Stiliyan Kalitzin; Willemiek Zweiphenning; Dorien van Blooijs; Maryse van’t Klooster; Pieter Van Eijsden; Frans Leijten; Maeike Zijlmans; RESPect Group
Published in: Scientific Reports, Issue 2, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-71359-2

Pausing propofol during neurosurgery to record intraoperative electrocorticography is feasible;10 years of clinical experience

Author(s): Sun, Dongqing; van ’t Klooster, Maryse A.; Ringeling, Elise M.; Schaft, Eline V.; van Rijen, Peter C.; Leijten, Frans S.S.; Demuru, Matteo; Robe, Pierre A.J.T.; Hoff, Reinier G.; Zijlmans, Maeike; the RESPect database group
Published in: Clin Neurophysiol, Issue 1, 2024, ISSN 1388-2457
Publisher: Elsevier BV