The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Informazioni relative al progetto

Epilepsy_Core

ID dell’accordo di sovvenzione: 803880

DOI

10.3030/803880

Progetto chiuso

Data della firma CE 15 Febbraio 2019

Data di avvio 1 Marzo 2019

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (35)

Machine learning for (non–)epileptic tissue detection from the intraoperative electrocorticogram

Autori: Sem Hoogteijling, Eline V. Schaft, Evi H.M. Dirks, Sven Straumann, Matteo Demuru, Pieter van Eijsden, Tineke Gebbink, Willem M. Otte, Geertjan M. Huiskamp, Maryse A. van ’t Klooster, Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 167, 2025, Pagina/e 14-25, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2024.08.012

HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy

Autori: Julia Jacobs, Maeike Zijlmans
Pubblicato in: Epilepsy Currents, Numero 20, 2025, Pagina/e 338-347, ISSN 1535-7597
Editore: American Epilepsy Society
DOI: 10.1177/1535759720957308

Implementing intraoperative high‐density electrocorticography during epilepsy surgery

Autori: Eline V. Schaft, Dongqing Sun, Sem Hoogteijling, Ziyi Wang, Frans S. S. Leijten, Pieter van Eijsden, Nick F. Ramsey, Pierre Robe, Maryse A. van 't Klooster, Maeike Zijlmans, null null
Pubblicato in: Epilepsia, Numero 66, 2025, Pagina/e 1447-1461, ISSN 0013-9580
Editore: Blackwell Publishing Inc.
DOI: 10.1111/epi.18302

High-frequency oscillations in scalp EEG: A systematic review of methodological choices and clinical findings

Autori: Lotte Noorlag, Nicole E.C. van Klink, Katsuhiro Kobayashi, Jean Gotman, Kees P.J. Braun, Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 137, 2025, Pagina/e 46-58, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2021.12.017

High frequency oscillations associate with neuroinflammation in low-grade epilepsy associated tumors

Autori: Dongqing Sun, Nicole E.C. van Klink, Anika Bongaarts, Willemiek E.J.M. Zweiphenning, Maryse A van 't Klooster, Tineke A Gebbink, Tom J Snijders, Pieter van Eijsden, Pierre A.J.T. Robe, Eleonora Aronica, Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 133, 2025, Pagina/e 165-174, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2021.08.025

Structural and effective brain connectivity in focal epilepsy

Autori: S.B. Jelsma, M. Zijlmans, I.B. Heijink, F.W.A. Hoefnagels, M. Raemaekers, W.M. Otte, N.E.C. van Klink, D. van Blooijs
Pubblicato in: NeuroImage: Reports, Numero 5, 2025, Pagina/e 100274, ISSN 2666-9560
Editore: Elsevier BV
DOI: 10.1016/j.ynirp.2025.100274

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial

Autori: Willemiek Zweiphenning, Maryse A van 't Klooster, Nicole E C van Klink, Frans S S Leijten, Cyrille H Ferrier, Tineke Gebbink, Geertjan Huiskamp, Martine J E van Zandvoort, Monique M J van Schooneveld, M Bourez, Sophie Goemans, Sven Straumann, Peter C van Rijen, Peter H Gosselaar, Pieter van Eijsden, Willem M Otte, Eric van Diessen, Kees P J Braun, Maeike Zijlmans, Eltje M. Bloemen-Carlier, Veronik
Pubblicato in: The Lancet Neurology, Numero 21, 2025, Pagina/e 982-993, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00311-8

Signaalkarakteristieken in mensen met een focale corticale dysplasie

Autori: Eline Schaft, Maryse Van 't Klooster, Maeike Zijlmans
Pubblicato in: Epilepsie, periodiek voor professionals, Numero 21, 2022, Pagina/e 13-15, ISSN 1571-0408
Editore: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.12874

A Practical Workflow for Organizing Clinical Intraoperative and Long-term iEEG Data in BIDS

Autori: Matteo Demuru, Dorien van Blooijs, Willemiek Zweiphenning, Dora Hermes, Frans Leijten, Maeike Zijlmans, null null
Pubblicato in: Neuroinformatics, Numero 20, 2022, Pagina/e 727-736, ISSN 1539-2791
Editore: Humana Press, Inc.
DOI: 10.1007/s12021-022-09567-6

Editorial: high-frequency oscillations in the hippocampus as biomarkers of pathology and healthy brain function

Autori: Johannes Sarnthein, Julia Jacobs, Maeike Zijlmans
Pubblicato in: Frontiers in Human Neurosience, 2021, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fnhum.2021.763881

The resolution revolution: Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient.

Autori: Willemiek Zweiphenning; Eric van Diessen; Erik J. Aarnoutse; Frans S. S. Leijten; Peter C. van Rijen; Kees P.J. Braun; Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 1, 2020, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2020.02.006

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Autori: Ziyi Wang, Jiaojiao Guo, Maryse van 't Klooster, Sem Hoogteijling, Julia Jacobs, Maeike Zijlmans
Pubblicato in: Neurology, Numero 102, 2024, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000209216

Super-resolution for localizing electrode grids as small, deformable objects during epilepsy surgery using augmented reality headsets

Autori: Hizirwan S. Salim, Abdullah Thabit, Sem Hoogteijling, Maryse A. van ’t Klooster, Theo van Walsum, Maeike Zijlmans, Mohamed Benmahdjoub
Pubblicato in: International Journal of Computer Assisted Radiology and Surgery, Numero 20, 2025, Pagina/e 2319-2327, ISSN 1861-6429
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11548-025-03401-5

Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations

Autori: Vasileios Dimakopoulos, Jean Gotman, Petr Klimes, Nicolas von Ellenrieder, Shi Bei Tan, Garnett Smith, Stephen V Gliske, Margarita Maltseva, Minette Krisel Manalo, Martin Pail, Milan Brazdil, Dorien van Blooijs, Maryse A van ‘t Klooster, Sarah Johnson, Samantha Laboy, Debora Ledergerber, Lukas Imbach, Christos Papadelis, Michael R Sperling, Maeike Zijlmans, Jan Cimbalnik, Julia Jacobs, William C
Pubblicato in: Brain, Numero 148, 2025, Pagina/e 1769-1777, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awae361

Intraoperative mapping of epileptogenic foci and tumor infiltration in neuro-oncology patients with epilepsy

Autori: Dongqing Sun, Eline V Schaft, Bibi M van Stempvoort, Tineke A Gebbink, Maryse van ‘t Klooster, Pieter van Eijsden, Sandra M A van der Salm, Jan Willem Dankbaar, Maeike Zijlmans, Pierre A Robe
Pubblicato in: Neuro-Oncology Advances, Numero 6, 2024, ISSN 2632-2498
Editore: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae125

High frequency oscillations relate to cognitive improvement after epilepsy surgery in children

Autori: Dongqing Sun; Maryse A. van 't Klooster; Monique M.J. van Schooneveld; Willemiek Zweiphenning; Nicole van Klink; Cyrille H. Ferrier; Peter H. Gosselaar; Kees P.J. Braun; Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 1, 2020, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2020.01.019

The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Autori: Sven Straumann, Eline Schaft, Herke Jan Noordmans, Jan Willem Dankbaar, Willem M Otte, Josee van Steenis, Paul Smits, Willemiek Zweiphenning, Pieter van Eijsden, Tineke Gebbink, Luigi Mariani, Maryse A van’t Klooster, Maeike Zijlmans
Pubblicato in: Brain Communications, Numero 4, 2023, ISSN 2632-1297
Editore: Oxford University Press (OUP)
DOI: 10.1093/braincomms/fcac302

Seizure Outcome After Intraoperative Electrocorticography-Tailored Epilepsy Surgery

Autori: Jiaojiao Guo, Ziyi Wang, Maryse A. van 't Klooster, Sandra M. Van Der Salm, Frans S. Leijten, Kees P. Braun, Maeike Zijlmans
Pubblicato in: Neurology, Numero 102, 2024, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000209430

Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?

Autori: Alessandra Maccabeo, Maryse A. van 't Klooster, Eline Schaft, Matteo Demuru, Willemiek Zweiphenning, Peter Gosselaar, Tineke Gebbink, Wim M. Otte, Maeike Zijlmans
Pubblicato in: Frontiers in Neurology, Numero 13, 2022, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.797075

Potential merits and flaws of large language models in epilepsy care: A critical review

Autori: Eric van Diessen, Ramon A. van Amerongen, Maeike Zijlmans, Willem M. Otte
Pubblicato in: Epilepsia, Numero 65, 2024, Pagina/e 873-886, ISSN 0013-9580
Editore: Blackwell Publishing Inc.
DOI: 10.1111/epi.17907

Learn how to interpret and use intracranial <scp>EEG</scp> findings

Autori: B. Frauscher, D. Mansilla, C. Abdallah, A. Astner‐Rohracher, S. Beniczky, M. Brazdil, V. Gnatkovsky, J. Jacobs, G. Kalamangalam, P. Perucca, P. Ryvlin, S. Schuele, J. Tao, Y. Wang, M. Zijlmans, A. McGonigal
Pubblicato in: Epileptic Disorders, Numero 26, 2024, Pagina/e 1-59, ISSN 1294-9361
Editore: John Libbey Eurotext
DOI: 10.1002/epd2.20190

HFO-trial: resultaten van een Randomised Controlled Trial in epilepsiechirurgie

Autori: Maryse van ‘t Klooster, Willemiek Zweiphenning, Maeike Zijlmans
Pubblicato in: Epilepsie, periodiek voor professionals, Numero 21, 2022, Pagina/e 11-12, ISSN 1571-0408
Editore: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.12873

Are HFOs in the intraoperative ECoG related to hippocampal clerosis, vlume and IQ?

Autori: Paula Agudelo Valencia, Nicole EC van Klink, Maryse A van 't Klooster, Willemiek JEM Zweiphenning, Banu Swampillai, Pieter van Eijsden, Tineke Gebbink, MArtine JE van Zandvoort, Maeike Zijlmans
Pubblicato in: Frontiers in Neurology, 2021, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.645925

Nasopharyngeal electrodes for recording mesiotemporal spikes: Post-covid revival?

Autori: Maeike Zijlmans, Sandra van der Salm, Maryse van 't Klooster
Pubblicato in: Clinical Neurophysiology, 2021, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2021.04.004

Do acute postoperative seizures predict epilepsy surgery outcome? a scoping review

Autori: Sebastiaan E. A. van Maanen, Maeike J. M. Zijlmans, Pieter van Eijsden, Sandra M. A. van der Salm
Pubblicato in: Acta Neurochirurgica, Numero 167, 2025, ISSN 0942-0940
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00701-025-06486-8

Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery?

Autori: Nicole EC van Klink, Willemiek JEM Zweiphenning, Cyrille H Ferrier, Peter H Gosselaar, Kai J Miller, Eleonora Aronica, Kees PJ Braun, Maeike Zijlmans
Pubblicato in: Epilepsia, 2021, ISSN 1528-1167
Editore: Wiley
DOI: 10.1111/epi.16845

Spatial and temporal properties of intra-operatively recorded spikes and high frequency oscillations in focal cortical dysplasia

Autori: Eline V. Schaft, Dongqing Sun, Maryse A. van 't Klooster, Dorien van Blooijs, Paul L. Smits, Willemiek J.E.M. Zweiphenning, Peter H. Gosselaar, Cyrille H. Ferrier, Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology, Numero 162, 2024, Pagina/e 210-218, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2024.03.038

Intra-operatieve elektrocorticografie bij tumorgerelateerde epilepsie

Autori: Sem Hoogteijling, Dongqing Sun
Pubblicato in: Epilepsie, periodiek voor professionals, Numero 19, 2021, Pagina/e 11-13, ISSN 1571-0408
Editore: Nederlandse Liga tegen Epilepsie
DOI: 10.54160/epilepsie.11398

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Autori: Matteo Demuru, Willemiek Zweiphenning, Dorien van Blooijs, Pieter Van Eijsden, Frans Leijten, Maeike Zijlmans, Stiliyan Kalitzin
Pubblicato in: Journal of Neural Engineering, 2020, ISSN 1741-2560
Editore: Institute of Physics Publishing
DOI: 10.1088/1741-2552/abc3a8

Robust compression and detection of epileptiform patterns in ECoG using a real-time spiking neural network hardware framework

Autori: Filippo Costa, Eline V. Schaft, Geertjan Huiskamp, Erik J. Aarnoutse, Maryse A. van’t Klooster, Niklaus Krayenbühl, Georgia Ramantani, Maeike Zijlmans, Giacomo Indiveri, Johannes Sarnthein
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47495-y

Deep learning for epileptogenic zone delineation from the invasive EEG: challenges and lookouts

Autori: Sem Hoogteijling, Maeike Zijlmans
Pubblicato in: Brain Communications, Numero 4, 2022, ISSN 2632-1297
Editore: Oxford University Press (OUP)
DOI: 10.1093/braincomms/fcab307

The optimal montage to mark interictal epileptiform discharges and high-frequency oscillations in intraoperative electrocorticography

Autori: Ziyi Wang, Jiaojiao Guo, Eline Schaft, Sem Hoogteijling, Cyrille H. Ferrier, Gerhard H. Visser, Dongqing Sun, Friso Hoefnagels, Taku Inada, Sandra van der Salm, Geertjan Huiskamp, Nicole van Klink, Maryse van’t Klooster, Maeike Zijlmans
Pubblicato in: Clinical Neurophysiology Practice, Numero 10, 2025, Pagina/e 246-255, ISSN 2467-981X
Editore: Elsevier BV
DOI: 10.1016/j.cnp.2025.06.007

Clinical characteristics and diagnoses of 1213 children referred to a first seizure clinic

Autori: Geertruida Slinger, Lotte Noorlag, Eric van Diessen, Willem M. Otte, Maeike Zijlmans, Floor E. Jansen, Kees P. J. Braun
Pubblicato in: Epilepsia Open, Numero 9, 2025, Pagina/e 548-557, ISSN 2470-9239
Editore: Wiley
DOI: 10.1002/epi4.12883

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.

Autori: Matteo Demuru; Stiliyan Kalitzin; Willemiek Zweiphenning; Dorien van Blooijs; Maryse van’t Klooster; Pieter Van Eijsden; Frans Leijten; Maeike Zijlmans; RESPect Group
Pubblicato in: Scientific Reports, Numero 2, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-71359-2

Pausing propofol during neurosurgery to record intraoperative electrocorticography is feasible;10 years of clinical experience

Autori: Sun, Dongqing; van ’t Klooster, Maryse A.; Ringeling, Elise M.; Schaft, Eline V.; van Rijen, Peter C.; Leijten, Frans S.S.; Demuru, Matteo; Robe, Pierre A.J.T.; Hoff, Reinier G.; Zijlmans, Maeike; the RESPect database group
Pubblicato in: Clin Neurophysiol, Numero 1, 2024, ISSN 1388-2457
Editore: Elsevier BV